Driving from Artigas to Colonia del Sacramento: 382 miles, roughly 8 h 54 min without stops. Road by road, 5 places to stop and the State Department advisory.
Driving from Rivera to Colonia del Sacramento: 324 miles, roughly 7 h 19 min without stops. Road by road, 6 places to stop and the State Department advisory.
Tacuarembó to Colonia del Sacramento: 255 miles (411 km), about 5 h 58 min of driving. The route, U.S. travel advisory for Uruguay and 4 stops on the way.
7 stops between Paysandú and Colonia del Sacramento, plus the route: 188 miles (303 km), about 4 h 54 min of driving and the U.S. travel advisory level.