Plan on about 5 h 58 min of driving for the 255-mile (411 km) trip from Tacuarembó to Colonia del Sacramento, before any stops.
Full advisory: Uruguay. Advisory issued: Uruguay July 28, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Uruguay: “Illumination, pavement markings, and road surfaces for secondary roads can be poor.”
| Distance | 255 mi (411 km) |
|---|---|
| Driving time, no stops | 5 h 58 min |
| Departments on the route | Tacuarembó, Durazno, Flores, Soriano, Colonia |
| Fuel estimate (car at 25 mpg) | about 10.2 gal; actual use varies by vehicle and traffic |
| Stops listed below | 4 |
On the road from Tacuarembó to Colonia del Sacramento
It runs through 5 departments: Tacuarembó, Durazno, Flores, Soriano, Colonia. Of the 4 stops listed below, 2 are within a mile of the road.
Tacuarembó to Colonia del Sacramento: the road sequence
| Road | Route miles (from–to) | Length, mi | Department |
|---|---|---|---|
| local roads | 0–128 | 128 | Tacuarembó, Durazno |
| connecting roads | 128–130 | 2 | Durazno |
| local roads | 130–153 | 23 | Durazno, Flores |
| connecting roads | 153–155 | 2 | Flores |
| local roads | 155–191 | 36 | Flores, Soriano |
| connecting roads | 191–192 | 1 | Soriano |
| local roads | 192–222 | 30 | Soriano, Colonia |
| connecting roads | 222–226 | 4 | Colonia |
| local roads | 226–255 | 29 | Colonia |
- Mile 89 of this route: Tacuarembó → Durazno (department line)
- Mile 133 of this route: Durazno → Flores (department line)
- Mile 178 of this route: Flores → Soriano (department line)
- Mile 194 of this route: Soriano → Colonia (department line)
What to see on the way from Tacuarembó to Colonia del Sacramento
- Right off the route (under 1 mile): Casa de Rivera, Durazno (mile 129), Museum of Rosario Mural Art (mile 224)
- Nature and outdoors: Chorro de Agua Fría (mile 25), Reserva de Flora y fauna Dr. Rodolfo Tálice (mile 155)
- Museums and history: Casa de Rivera, Durazno (mile 129), Museum of Rosario Mural Art (mile 224)
Chorro de Agua Fría
In Uruguay's Tacuarembó Department, Chorro de Agua Fría is a waterfall that drops roughly 14 meters, the highest uninterrupted fall in the country.
Casa de Rivera, Durazno
Facing Plaza Independencia in Durazno, the Casa de Fructuoso Rivera (Casa de Rivera) is one of the town's main heritage sites and now houses the department's historical museum.
Reserva de Flora y fauna Dr. Rodolfo Tálice
Off Route 3 near Trinidad, the Dr. Rodolfo Tálice Ecopark (Reserva de Flora y Fauna Dr. Rodolfo Talice) is a fenced wildlife reserve where axis deer, greater rheas and pampas deer roam free alongside other species.
Museum of Rosario Mural Art
Rather than a building, the Museum of Rosario Mural Art is a circuit of history-themed murals spread around Rosario, in Uruguay's Colonia department.
In Colonia del Sacramento itself
Museo del Origami
Set in the historic district of Colonia del Sacramento, Museo del Origami is a nonprofit museum devoted to the art of paper folding and part of Uruguay's national museum system.
Museo Paleontológico Profesor Armando Calcaterra
In the Real de San Carlos area of Colonia del Sacramento, Museo Paleontológico Profesor Armando Calcaterra shows about 1,600 pieces, including fossil vertebrates and invertebrates and Indigenous artifacts.
Basílica del Santísimo Sacramento, Colonia del Sacramento
In Colonia del Sacramento, Uruguay, the Basílica del Santísimo Sacramento (Basilica of the Holy Sacrament) is a Roman Catholic parish church you can stop at in town.
More drives to Colonia del Sacramento
- Mercedes, Uruguay to Colonia del Sacramento
- Paysandú to Colonia del Sacramento
- Salto to Colonia del Sacramento
- Rivera to Colonia del Sacramento
- Artigas to Colonia del Sacramento
- Florida, Uruguay to Colonia del Sacramento
From Tacuarembó to other places in Uruguay
- Tacuarembó to Carmelo
- Tacuarembó to Conchillas
- Tacuarembó to Nueva Helvecia
- Tacuarembó to Veinticinco de Agosto
- Tacuarembó to Minas
- Tacuarembó to Piriápolis
Frequently asked questions
How long does it take to drive from Tacuarembó to Colonia del Sacramento?
About 5 h 58 min of driving without stops, over 255 miles.
How far is Colonia del Sacramento from Tacuarembó by car?
About 255 miles (411 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the Tacuarembó to Colonia del Sacramento drive?
The U.S. State Department rates Uruguay Level 2: Exercise Increased Caution. Read the full advisory before you go.
Where can you stop on the way from Tacuarembó to Colonia del Sacramento?
Closest to the road: Chorro de Agua Fría (waterfall, mile 25, 2 mi from the route); Casa de Rivera, Durazno (historic house museum, mile 129, 0.1 mi from the route); Museum of Rosario Mural Art (art museum, mile 224, 0.2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.