Plan on about 2 h 51 min of driving for the 112-mile (181 km) trip from Mercedes, Uruguay to Colonia del Sacramento, before any stops.
Full advisory: Uruguay. Advisory issued: Uruguay July 28, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Uruguay: “If you are in an accident involving injury, stay in place until a police officer arrives.”
| Total distance | 112 mi (181 km) |
|---|---|
| Driving time, no stops | 2 h 51 min |
| Departments on the route | Soriano, Colonia |
| Fuel estimate (car at 25 mpg) | about 4.5 gal; actual use varies by vehicle and traffic |
| Stops listed below | 5 |
Driving Mercedes to Colonia del Sacramento: the shape of the trip
It runs through 2 departments: Soriano, Colonia. Of the 5 stops listed below, 1 are within a mile of the road.
The route from Mercedes to Colonia del Sacramento, road by road
| Road | Route miles (from–to) | Length, mi | Department |
|---|---|---|---|
| local roads | 0–112 | 112 | Soriano, Colonia |
- Mile 52 of this route: Soriano → Colonia (department line)
What to see on the way from Mercedes to Colonia del Sacramento
- Right off the route (under 1 mile): Museo Municipal Profesor Roselli (mile 51)
- Nature and outdoors: Agraciada Beach (mile 48), Anchorena Presidential Estate (mile 98)
- Museums and history: Museo Municipal Profesor Roselli (mile 51), Museo del Carmen (mile 66)
Agraciada Beach
On the eastern bank of the Uruguay River in Soriano department, Agraciada Beach is a historic beach area facing Argentina's Entre Ríos province.
Museo Municipal Profesor Roselli
Nueva Palmira's municipal museum, also known as the Museo Roselli, is named for its first director, Professor Francisco Lucas Rosselli.
Teatro Uamá
Teatro Uamá is a theater in the city of Carmelo, in Uruguay's Colonia department, regarded as the town's leading cultural institution.
Museo del Carmen
Facing Plaza Artigas in Carmelo, the Archivo y Museo del Carmen belongs to the local Carmelo parish and holds religious and historical collections.
Anchorena Presidential Estate
Located in Colonia Department, 208 km from Montevideo, the Anchorena Presidential Estate is a national park that also serves as a rest residence for Uruguay's president.
In Colonia del Sacramento itself
Basílica del Santísimo Sacramento, Colonia del Sacramento
In Colonia del Sacramento, Uruguay, the Basílica del Santísimo Sacramento (Basilica of the Holy Sacrament) is a Roman Catholic parish church you can stop at in town.
Colonia del Sacramento Lighthouse
Erected in 1857 on the ruins of the Saint Francis Xavier convent, the Colonia del Sacramento Lighthouse stands in the town's historic district in Uruguay.
Museo del Origami
Set in the historic district of Colonia del Sacramento, Museo del Origami is a nonprofit museum devoted to the art of paper folding and part of Uruguay's national museum system.
More drives to Colonia del Sacramento
- Paysandú to Colonia del Sacramento
- Tacuarembó to Colonia del Sacramento
- Salto to Colonia del Sacramento
- Rivera to Colonia del Sacramento
- Artigas to Colonia del Sacramento
- Florida, Uruguay to Colonia del Sacramento
From Mercedes to other places in Uruguay
- Mercedes, Uruguay to Alejandro Gallinal
- Mercedes, Uruguay to Cabo Polonio
- Mercedes, Uruguay to Chuy
- Mercedes, Uruguay to Río Branco
- Mercedes, Uruguay to Tigre, Argentina
- Mercedes, Uruguay to Villa Gesell, Argentina
Frequently asked questions
How long does it take to drive from Mercedes, Uruguay to Colonia del Sacramento?
About 2 h 51 min of driving without stops, over 112 miles.
What is the driving distance from Mercedes, Uruguay to Colonia del Sacramento?
About 112 miles (181 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from Mercedes, Uruguay to Colonia del Sacramento?
The U.S. State Department rates Uruguay Level 2: Exercise Increased Caution. Read the full advisory before you go.
Where can you stop on the way from Mercedes to Colonia del Sacramento?
Closest to the road: Museo Municipal Profesor Roselli (museum, mile 51, 0.7 mi from the route); Teatro Uamá (theater, mile 66, 1 mi from the route); Museo del Carmen (private museum, mile 66, 1 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.