The Wayro route from Artigas to Colonia del Sacramento is 382 miles (615 km), about 8 h 54 min of driving without stops.
Full advisory: Uruguay. Advisory issued: Uruguay July 28, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Uruguay: “Several of the main highways are particularly accident-ridden.”
| Distance by road | 382 mi (615 km) |
|---|---|
| Drive time without stops | 8 h 54 min |
| Departments on the route | Artigas, Salto, Rivera, Tacuarembó, Durazno, Flores, Soriano, Colonia |
| Fuel estimate (car at 25 mpg) | about 15.3 gal; actual use varies by vehicle and traffic |
| Stops listed below | 5 |
How the Artigas to Colonia del Sacramento drive plays out
It runs through 8 departments: Artigas, Salto, Rivera, Tacuarembó, Durazno, Flores, Soriano, Colonia. Of the 5 stops listed below, 3 are within a mile of the road.
Artigas to Colonia del Sacramento: the road sequence
| Road | Route miles (from–to) | Length, mi | Department |
|---|---|---|---|
| local roads | 0–84 | 84 | Artigas, Salto, Rivera |
| connecting roads | 84–85 | 1 | Rivera |
| local roads | 85–255 | 170 | Rivera, Tacuarembó, Durazno |
| connecting roads | 255–258 | 3 | Durazno |
| local roads | 258–280 | 22 | Durazno, Flores |
| connecting roads | 280–281 | 1 | Flores |
| local roads | 281–318 | 37 | Flores, Soriano |
| connecting roads | 318–319 | 1 | Soriano |
| local roads | 319–350 | 31 | Soriano, Colonia |
| connecting roads | 350–352 | 2 | Colonia |
| local roads | 352–382 | 30 | Colonia |
- Mile 45 of this route: Artigas → Salto (department line)
- Mile 58 of this route: Salto → Rivera (department line)
- Mile 107 of this route: Rivera → Tacuarembó (department line)
- Mile 217 of this route: Tacuarembó → Durazno (department line)
- Mile 260 of this route: Durazno → Flores (department line)
- Mile 306 of this route: Flores → Soriano (department line)
- Mile 321 of this route: Soriano → Colonia (department line)
Breaking up the drive: stops between Artigas and Colonia del Sacramento
- Right off the route (under 1 mile): Museo de Artes Visuales de Tacuarembó (mile 127), Casa de Rivera, Durazno (mile 256), Museum of Rosario Mural Art (mile 350)
- Nature and outdoors: Chorro de Agua Fría (mile 153), Reserva de Flora y fauna Dr. Rodolfo Tálice (mile 282)
- Museums and history: Museo de Artes Visuales de Tacuarembó (mile 127), Casa de Rivera, Durazno (mile 256), Museum of Rosario Mural Art (mile 350)
Museo de Artes Visuales de Tacuarembó
The Museum of Visual Arts of Tacuarembó (Museo de Artes Visuales) is a museum in the city of Tacuarembó, Uruguay.
Chorro de Agua Fría
In Uruguay's Tacuarembó Department, Chorro de Agua Fría is a waterfall that drops roughly 14 meters, the highest uninterrupted fall in the country.
Casa de Rivera, Durazno
Facing Plaza Independencia in Durazno, the Casa de Fructuoso Rivera (Casa de Rivera) is one of the town's main heritage sites and now houses the department's historical museum.
Reserva de Flora y fauna Dr. Rodolfo Tálice
Off Route 3 near Trinidad, the Dr. Rodolfo Tálice Ecopark (Reserva de Flora y Fauna Dr. Rodolfo Talice) is a fenced wildlife reserve where axis deer, greater rheas and pampas deer roam free alongside other species.
Museum of Rosario Mural Art
Rather than a building, the Museum of Rosario Mural Art is a circuit of history-themed murals spread around Rosario, in Uruguay's Colonia department.
In Colonia del Sacramento itself
Basílica del Santísimo Sacramento, Colonia del Sacramento
In Colonia del Sacramento, Uruguay, the Basílica del Santísimo Sacramento (Basilica of the Holy Sacrament) is a Roman Catholic parish church you can stop at in town.
Museo Paleontológico Profesor Armando Calcaterra
In the Real de San Carlos area of Colonia del Sacramento, Museo Paleontológico Profesor Armando Calcaterra shows about 1,600 pieces, including fossil vertebrates and invertebrates and Indigenous artifacts.
Colonia del Sacramento Lighthouse
Erected in 1857 on the ruins of the Saint Francis Xavier convent, the Colonia del Sacramento Lighthouse stands in the town's historic district in Uruguay.
More drives to Colonia del Sacramento
- Mercedes, Uruguay to Colonia del Sacramento
- Paysandú to Colonia del Sacramento
- Tacuarembó to Colonia del Sacramento
- Salto to Colonia del Sacramento
- Rivera to Colonia del Sacramento
- Florida, Uruguay to Colonia del Sacramento
From Artigas to other places in Uruguay
- Artigas to Mercedes, Uruguay
- Artigas to Carmelo
- Artigas to Conchillas
- Artigas to Nueva Helvecia
- Artigas to Veinticinco de Agosto
- Artigas to Florida, Uruguay
Frequently asked questions
How long is the drive from Artigas to Colonia del Sacramento?
About 8 h 54 min of driving without stops, over 382 miles.
How far is Colonia del Sacramento from Artigas by car?
About 382 miles (615 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from Artigas to Colonia del Sacramento?
The U.S. State Department rates Uruguay Level 2: Exercise Increased Caution. Read the full advisory before you go.
What are good stops between Artigas and Colonia del Sacramento?
Closest to the road: Museo de Artes Visuales de Tacuarembó (museum, mile 127, 0.7 mi from the route); Casa de Rivera, Durazno (historic house museum, mile 256, 0.1 mi from the route); Museum of Rosario Mural Art (art museum, mile 350, 0.3 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.