Driving from Encarnación to San Bernardino: 216 miles, roughly 5 h 33 min without stops. Road by road, 3 places to stop and the State Department advisory.
San Ignacio, Paraguay to Neuland: 436 miles (702 km), about 11 h 30 min of driving. The route, U.S. travel advisory for Paraguay and 4 stops on the way.
4 stops between San Ignacio, Paraguay and Filadelfia, plus the route: 421 miles (678 km), about 10 h 53 min of driving and the U.S. travel advisory level.
Pedro Juan Caballero to San Ignacio, Paraguay: 393 miles (632 km), about 9 h 30 min of driving. The route, U.S. travel advisory for Paraguay and 4 stops.