Colonia del Sacramento to Fray Marcos: 152 miles (244 km), about 3 h 29 min of driving. The route, U.S. travel advisory for Uruguay and 4 stops on the way.
Driving from Artigas to Florida, Uruguay: 312 miles, roughly 6 h 46 min without stops. Road by road, 4 places to stop and the State Department advisory.
8 stops between Bella Unión and Veinticinco de Agosto, plus the route: 352 miles (566 km), about 7 h 8 min of driving and the U.S. travel advisory level.