The Wayro route from Pergamino to Colonia del Sacramento, Uruguay is 345 miles (556 km), about 7 h 24 min of driving without stops. You cross from Argentina into Uruguay at about mile 214, at the Gualeguaychú–Fray Bentos bridge.
Full advisory: Argentina, Uruguay. Advisory issued: Argentina July 10, 2026; Uruguay July 28, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers in Argentina tend to be aggressive, especially in Buenos Aires, and often ignore traffic regulations.”
- Uruguay: “Illumination, pavement markings, and road surfaces for secondary roads can be poor.”
| Total distance | 345 mi (556 km) |
|---|---|
| Time at the wheel, no stops | 7 h 24 min |
| Main roads, in order | RN8 → RN193 → RN12 → RN14 → RN136 |
| Border crossing | about mile 214, Argentina → Uruguay (the Gualeguaychú–Fray Bentos bridge) |
| Regions on the route | Buenos Aires, Entre Ríos, Río Negro, Soriano, Colonia |
| Fuel estimate (car at 25 mpg) | about 13.8 gal; actual use varies by vehicle and traffic |
| Stops listed below | 9 |
Crossing from Argentina into Uruguay
The route crosses at about mile 214, at the Gualeguaychú–Fray Bentos bridge, from Entre Ríos into Río Negro. Plan on two checks on each side: immigration for your passport and customs for the car.
| Entering Uruguay (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. |
|---|---|
| Driving in Uruguay | You can drive on your U.S. license. |
| Entering Argentina (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid when you enter; leave a blank page for the entry and exit stamps. |
| Driving in Argentina | A valid U.S. license usually works; an International Driving Permit is recommended. |
| Rental car | Cross only if the rental company authorizes it in writing and gives you the papers for the border; ask before you book. |
Sources: U.S. State Department, Uruguay (updated August 13, 2026); U.S. State Department, Argentina (updated July 16, 2026). Checked October 10, 2026; rules change, so confirm before you go.
The Pergamino–Colonia del Sacramento drive in a few lines
RN8 (76 mi) and RN12 (50 mi) carry about 37% of the 345 miles. The first 214 miles are in Argentina; the last 131 are in Uruguay. It runs through 5 regions: Buenos Aires, Entre Ríos, Río Negro, Soriano, Colonia. Of the 9 stops listed below, 2 are within a mile of the road.
Pergamino to Colonia del Sacramento: the road sequence
| Road | Route miles (from–to) | Length, mi | Region |
|---|---|---|---|
| local roads | 0–4 | 4 | Buenos Aires |
| RN8 | 4–80 | 76 | Buenos Aires |
| connecting roads | 80–81 | 1 | Buenos Aires |
| RN193 | 81–100 | 19 | Buenos Aires |
| RN12 | 100–150 | 50 | Buenos Aires, Entre Ríos |
| RN14 | 150–186 | 36 | Entre Ríos |
| local roads | 186–193 | 7 | Entre Ríos |
| RN136 | 193–212 | 19 | Entre Ríos |
| connecting roads | 212–214 | 2 | Entre Ríos |
| local roads | 214–233 | 19 | Río Negro, Soriano |
| connecting roads | 233–235 | 2 | Soriano |
| local roads | 235–345 | 110 | Soriano, Colonia |
- Mile 120 of this route: Buenos Aires → Entre Ríos (region line)
- Mile 214 of this route: Entre Ríos → Río Negro (international border)
- Mile 231 of this route: Río Negro → Soriano (region line)
- Mile 285 of this route: Soriano → Colonia (region line)
Breaking up the drive: stops between Pergamino and Colonia del Sacramento
- Right off the route (under 1 mile): Parque Criollo y Museo Gauchesco Ricardo Gu͏̈iraldes (mile 69), Museo Municipal Profesor Roselli (mile 285)
- Nature and outdoors: Ciervo de los Pantanos National Park (mile 103), Agraciada Beach (mile 281), Anchorena Presidential Estate (mile 331)
- Museums and history: Parque Criollo y Museo Gauchesco Ricardo Gu͏̈iraldes (mile 69), Calera Real del Dacá (mile 232), Museo Municipal Profesor Roselli (mile 285), Museo del Carmen (mile 300)
Parque Criollo y Museo Gauchesco Ricardo Gu͏̈iraldes
In San Antonio de Areco, Buenos Aires province, the Museo Gauchesco Ricardo Güiraldes spreads ten exhibit rooms across the 97-hectare Parque Criollo, opened in 1938, and presents Argentina's past, especially that of Buenos Aires province.
Ciervo de los Pantanos National Park
Marsh deer give their name to Ciervo de los Pantanos National Park, a Ramsar Site in Campana, Buenos Aires province, where waterbirds are abundant.
Frigorífico Anglo del Uruguay
Liebig exported meat extract and corned beef from this spot on the Uruguay River at Fray Bentos starting in 1865. In 1924, the Anglo plant began shipping frozen meat from the same site.
Calera Real del Dacá
On the eastern edge of Mercedes beside the Dacá stream, the ruins of the Calera Real lime works date to 1722 and are considered the region's first industrial site; recent works added visitor circuits, lighting and interpretive signs.
Agraciada Beach
On the eastern bank of the Uruguay River in Soriano department, Agraciada Beach is a historic beach area facing Argentina's Entre Ríos province.
Museo Municipal Profesor Roselli
Nueva Palmira's municipal museum, also known as the Museo Roselli, is named for its first director, Professor Francisco Lucas Rosselli.
Teatro Uamá
Teatro Uamá is a theater in the city of Carmelo, in Uruguay's Colonia department, regarded as the town's leading cultural institution.
Museo del Carmen
Facing Plaza Artigas in Carmelo, the Archivo y Museo del Carmen belongs to the local Carmelo parish and holds religious and historical collections.
Anchorena Presidential Estate
Located in Colonia Department, 208 km from Montevideo, the Anchorena Presidential Estate is a national park that also serves as a rest residence for Uruguay's president.
Once you reach Colonia del Sacramento
Museo del Origami
Set in the historic district of Colonia del Sacramento, Museo del Origami is a nonprofit museum devoted to the art of paper folding and part of Uruguay's national museum system.
Colonia del Sacramento Lighthouse
Erected in 1857 on the ruins of the Saint Francis Xavier convent, the Colonia del Sacramento Lighthouse stands in the town's historic district in Uruguay.
Basílica del Santísimo Sacramento, Colonia del Sacramento
In Colonia del Sacramento, Uruguay, the Basílica del Santísimo Sacramento (Basilica of the Holy Sacrament) is a Roman Catholic parish church you can stop at in town.
More drives to Colonia del Sacramento
- Mercedes, Uruguay to Colonia del Sacramento
- Paysandú to Colonia del Sacramento
- Tacuarembó to Colonia del Sacramento
- Salto to Colonia del Sacramento
- Rivera to Colonia del Sacramento
- Artigas to Colonia del Sacramento
More drives from Pergamino
- Pergamino to Adrogué
- Pergamino to Berisso
- Pergamino to Magdalena
- Pergamino to Chascomús
- Pergamino to Sierra de La Ventana
- Pergamino to Capilla del Monte
Frequently asked questions
How long is the drive from Pergamino to Colonia del Sacramento, Uruguay?
About 7 h 24 min of driving without stops, over 345 miles.
What is the driving distance from Pergamino to Colonia del Sacramento, Uruguay?
About 345 miles (556 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Where does the Pergamino to Colonia del Sacramento drive cross the border?
At about mile 214, from Argentina into Uruguay, at the Gualeguaychú–Fray Bentos bridge.
What do U.S. citizens need to drive from Pergamino into Uruguay?
No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. You can drive on your U.S. license. (U.S. State Department, updated August 13, 2026.)
What does the U.S. travel advisory say about the Pergamino to Colonia del Sacramento drive?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions; Uruguay Level 2: Exercise Increased Caution. Read the full advisory before you go.
Which highways go from Pergamino to Colonia del Sacramento?
In order: RN8, RN193, RN12, RN14 and RN136. The road-by-road table above shows the route miles for each one.
What are good stops between Pergamino and Colonia del Sacramento?
Closest to the road: Parque Criollo y Museo Gauchesco Ricardo Gu͏̈iraldes (museum, mile 69, 0.6 mi from the route); Museo Municipal Profesor Roselli (museum, mile 285, 0.7 mi from the route); Teatro Uamá (theater, mile 300, 1 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.