Plan on about 6 h 16 min of driving for the 278-mile (448 km) trip from Luján to Colonia del Sacramento, Uruguay, before any stops. You cross from Argentina into Uruguay at about mile 147, at the Gualeguaychú–Fray Bentos bridge.
Full advisory: Argentina, Uruguay. Advisory issued: Argentina July 10, 2026; Uruguay July 28, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers in Argentina tend to be aggressive, especially in Buenos Aires, and often ignore traffic regulations.”
- Uruguay: “If you are in an accident involving injury, stay in place until a police officer arrives.”
| Total distance | 278 mi (448 km) |
|---|---|
| Driving time, no stops | 6 h 16 min |
| Main roads, in order | RP47 → RP6 → RN12 → RN14 → RN136 |
| Border crossing | about mile 147, Argentina → Uruguay (the Gualeguaychú–Fray Bentos bridge) |
| Regions on the route | Buenos Aires, Entre Ríos, Río Negro, Soriano, Colonia |
| Fuel estimate (car at 25 mpg) | about 11.1 gal; actual use varies by vehicle and traffic |
| Stops listed below | 9 |
Crossing from Argentina into Uruguay
The route crosses at about mile 147, at the Gualeguaychú–Fray Bentos bridge, from Entre Ríos into Río Negro. Plan on two checks on each side: immigration for your passport and customs for the car.
| Entering Uruguay (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. |
|---|---|
| Driving in Uruguay | You can drive on your U.S. license. |
| Entering Argentina (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid when you enter; leave a blank page for the entry and exit stamps. |
| Driving in Argentina | A valid U.S. license usually works; an International Driving Permit is recommended. |
| Rental car | Cross only if the rental company authorizes it in writing and gives you the papers for the border; ask before you book. |
Sources: U.S. State Department, Uruguay (updated August 13, 2026); U.S. State Department, Argentina (updated July 16, 2026). Checked October 10, 2026; rules change, so confirm before you go.
On the road from Luján to Colonia del Sacramento
RN12 (47 mi) and RN14 (37 mi) carry about 30% of the 278 miles. The first 147 miles are in Argentina; the last 131 are in Uruguay. It runs through 5 regions: Buenos Aires, Entre Ríos, Río Negro, Soriano, Colonia. Of the 9 stops listed below, 2 are within a mile of the road.
Road-by-road breakdown: Luján to Colonia del Sacramento
| Road | Route miles (from–to) | Length, mi | Region |
|---|---|---|---|
| local roads | 0–1 | 1 | Buenos Aires |
| RP47 | 1–7 | 6 | Buenos Aires |
| connecting roads | 7–8 | 1 | Buenos Aires |
| RP6 | 8–35 | 27 | Buenos Aires |
| RN12 | 35–82 | 47 | Buenos Aires, Entre Ríos |
| RN14 | 82–119 | 37 | Entre Ríos |
| local roads | 119–126 | 7 | Entre Ríos |
| RN136 | 126–145 | 19 | Entre Ríos |
| connecting roads | 145–147 | 2 | Entre Ríos |
| local roads | 147–166 | 19 | Río Negro, Soriano |
| connecting roads | 166–168 | 2 | Soriano |
| local roads | 168–278 | 110 | Soriano, Colonia |
- Mile 53 of this route: Buenos Aires → Entre Ríos (region line)
- Mile 147 of this route: Entre Ríos → Río Negro (international border)
- Mile 163 of this route: Río Negro → Soriano (region line)
- Mile 218 of this route: Soriano → Colonia (region line)
What to see on the way from Luján to Colonia del Sacramento
- Right off the route (under 1 mile): Cathedral of Mercedes (mile 165), Museo Municipal Profesor Roselli (mile 217)
- Nature and outdoors: Ciervo de los Pantanos National Park (mile 26), Agraciada Beach (mile 214), Anchorena Presidential Estate (mile 264)
- Museums and history: Gualeguaychú Cathedral (mile 125), Alejandro Berro Paleontology Museum (mile 162), Cathedral of Mercedes (mile 165), Museo Municipal Profesor Roselli (mile 217), Museo del Carmen (mile 232)
Ciervo de los Pantanos National Park
Marsh deer give their name to Ciervo de los Pantanos National Park, a Ramsar Site in Campana, Buenos Aires province, where waterbirds are abundant.
Gualeguaychú Cathedral
St. Joseph's Cathedral, also called Gualeguaychú Cathedral, serves as the cathedral church of the Roman Catholic Diocese of Gualeguaychú in Argentina.
Alejandro Berro Paleontology Museum
In a 19th-century building in Mercedes' Parque Castillo Mauá, this paleontology museum opened in 1946 around the collection of naturalist Alejandro Berro; a well-preserved glyptodon shell found on a nearby riverbank is a highlight.
Cathedral of Mercedes
Since 1960, the Diocese of Mercedes has had its seat at the Cathedral of Our Lady of Mercy, the main Catholic church in this Uruguayan city.
Agraciada Beach
On the eastern bank of the Uruguay River in Soriano department, Agraciada Beach is a historic beach area facing Argentina's Entre Ríos province.
Museo Municipal Profesor Roselli
Nueva Palmira's municipal museum, also known as the Museo Roselli, is named for its first director, Professor Francisco Lucas Rosselli.
Teatro Uamá
Teatro Uamá is a theater in the city of Carmelo, in Uruguay's Colonia department, regarded as the town's leading cultural institution.
Museo del Carmen
Facing Plaza Artigas in Carmelo, the Archivo y Museo del Carmen belongs to the local Carmelo parish and holds religious and historical collections.
Anchorena Presidential Estate
Located in Colonia Department, 208 km from Montevideo, the Anchorena Presidential Estate is a national park that also serves as a rest residence for Uruguay's president.
Arriving in Colonia del Sacramento
Basílica del Santísimo Sacramento, Colonia del Sacramento
In Colonia del Sacramento, Uruguay, the Basílica del Santísimo Sacramento (Basilica of the Holy Sacrament) is a Roman Catholic parish church you can stop at in town.
Museo Paleontológico Profesor Armando Calcaterra
In the Real de San Carlos area of Colonia del Sacramento, Museo Paleontológico Profesor Armando Calcaterra shows about 1,600 pieces, including fossil vertebrates and invertebrates and Indigenous artifacts.
Colonia del Sacramento Lighthouse
Erected in 1857 on the ruins of the Saint Francis Xavier convent, the Colonia del Sacramento Lighthouse stands in the town's historic district in Uruguay.
More drives to Colonia del Sacramento
- Mercedes, Uruguay to Colonia del Sacramento
- Paysandú to Colonia del Sacramento
- Tacuarembó to Colonia del Sacramento
- Salto to Colonia del Sacramento
- Rivera to Colonia del Sacramento
- Artigas to Colonia del Sacramento
More drives from Luján
- Luján to Adrogué
- Luján to Berisso
- Luján to Magdalena
- Luján to Capilla del Monte
- Luján to Villa Carlos Paz
- Luján to Tacuarembó, Uruguay
Frequently asked questions
How long does it take to drive from Luján to Colonia del Sacramento, Uruguay?
About 6 h 16 min of driving without stops, over 278 miles.
How far is Colonia del Sacramento, Uruguay from Luján by car?
About 278 miles (448 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Where does the Luján to Colonia del Sacramento drive cross the border?
At about mile 147, from Argentina into Uruguay, at the Gualeguaychú–Fray Bentos bridge.
What do U.S. citizens need to drive from Luján into Uruguay?
No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. You can drive on your U.S. license. (U.S. State Department, updated August 13, 2026.)
Is it safe to drive from Luján to Colonia del Sacramento, Uruguay?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions; Uruguay Level 2: Exercise Increased Caution. Read the full advisory before you go.
Which highways go from Luján to Colonia del Sacramento?
In order: RP47, RP6, RN12, RN14 and RN136. The road-by-road table above shows the route miles for each one.
What are good stops between Luján and Colonia del Sacramento?
Closest to the road: Gualeguaychú Cathedral (cathedral, mile 125, 1 mi from the route); Cathedral of Mercedes (cathedral, mile 165, 0.7 mi from the route); Museo Municipal Profesor Roselli (museum, mile 217, 0.7 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.