Plan on about 7 h 22 min of driving for the 336-mile (541 km) trip from Berisso to Colonia del Sacramento, Uruguay, before any stops. You cross from Argentina into Uruguay at about mile 205, at the Gualeguaychú–Fray Bentos bridge.
Full advisory: Argentina, Uruguay. Advisory issued: Argentina July 10, 2026; Uruguay July 28, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers in Argentina tend to be aggressive, especially in Buenos Aires, and often ignore traffic regulations.”
- Uruguay: “Traffic fatalities are high in Uruguay.”
| Distance by road | 336 mi (541 km) |
|---|---|
| Driving time, no stops | 7 h 22 min |
| Main roads, in order | 114-05 → RN1 → AV1-N → RN9 → RP6 → RN12 → RN14 → RN136 |
| Border crossing | about mile 205, Argentina → Uruguay (the Gualeguaychú–Fray Bentos bridge) |
| Regions on the route | Buenos Aires, Ciudad de Buenos Aires, Entre Ríos, Río Negro, Soriano, Colonia |
| Fuel estimate (car at 25 mpg) | about 13.4 gal; actual use varies by vehicle and traffic |
| Stops listed below | 9 |
Getting across the Argentina–Uruguay border
The route crosses at about mile 205, at the Gualeguaychú–Fray Bentos bridge, from Entre Ríos into Río Negro. Plan on two checks on each side: immigration for your passport and customs for the car.
| Entering Uruguay (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. |
|---|---|
| Driving in Uruguay | You can drive on your U.S. license. |
| Entering Argentina (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid when you enter; leave a blank page for the entry and exit stamps. |
| Driving in Argentina | A valid U.S. license usually works; an International Driving Permit is recommended. |
| Rental car | Cross only if the rental company authorizes it in writing and gives you the papers for the border; ask before you book. |
Sources: U.S. State Department, Uruguay (updated August 13, 2026); U.S. State Department, Argentina (updated July 16, 2026). Checked October 10, 2026; rules change, so confirm before you go.
Driving Berisso to Colonia del Sacramento: the shape of the trip
RN12 (47 mi) and RN9 (40 mi) carry about 26% of the 336 miles. The first 205 miles are in Argentina; the last 131 are in Uruguay. It runs through 6 regions: Buenos Aires, Ciudad de Buenos Aires, Entre Ríos, Río Negro, Soriano, Colonia. Of the 9 stops listed below, 6 are within a mile of the road.
Road-by-road breakdown: Berisso to Colonia del Sacramento
| Road | Route miles (from–to) | Length, mi | Region |
|---|---|---|---|
| local roads | 0–1 | 1 | Buenos Aires |
| 114-05 | 1–4 | 3 | Buenos Aires |
| connecting roads | 4–7 | 3 | Buenos Aires |
| RN1 | 7–37 | 30 | Buenos Aires, Ciudad de Buenos Aires |
| local roads | 37–40 | 3 | Ciudad de Buenos Aires |
| AV1-N | 40–46 | 6 | Ciudad de Buenos Aires |
| connecting roads | 46–48 | 2 | Ciudad de Buenos Aires |
| RN9 | 48–88 | 40 | Ciudad de Buenos Aires, Buenos Aires |
| RP6 | 88–93 | 5 | Buenos Aires |
| RN12 | 93–140 | 47 | Buenos Aires, Entre Ríos |
| RN14 | 140–176 | 36 | Entre Ríos |
| local roads | 176–183 | 7 | Entre Ríos |
| RN136 | 183–202 | 19 | Entre Ríos |
| connecting roads | 202–205 | 3 | Entre Ríos |
| local roads | 205–224 | 19 | Río Negro, Soriano |
| connecting roads | 224–226 | 2 | Soriano |
| local roads | 226–336 | 110 | Soriano, Colonia |
- Mile 33 of this route: Buenos Aires → Ciudad de Buenos Aires (region line)
- Mile 49 of this route: Ciudad de Buenos Aires → Buenos Aires (region line)
- Mile 110 of this route: Buenos Aires → Entre Ríos (region line)
- Mile 205 of this route: Entre Ríos → Río Negro (international border)
- Mile 221 of this route: Río Negro → Soriano (region line)
- Mile 275 of this route: Soriano → Colonia (region line)
Places worth a stop between Berisso and Colonia del Sacramento
- Right off the route (under 1 mile): Museo Ferroviario de Tolosa (mile 7), Héctor Carlos Janson Historic and Numismatics Museum (mile 39), Museo de la Inmigración (mile 39), Buenos Aires Japanese Gardens (mile 42), Eduardo Sívori Museum (mile 43), Cathedral of Mercedes (mile 222)
- Nature and outdoors: Buenos Aires Japanese Gardens (mile 42), Agraciada Beach (mile 272), Anchorena Presidential Estate (mile 322)
- Museums and history: Museo Ferroviario de Tolosa (mile 7), Héctor Carlos Janson Historic and Numismatics Museum (mile 39), Museo de la Inmigración (mile 39), Eduardo Sívori Museum (mile 43), Cathedral of Mercedes (mile 222)
Museo Ferroviario de Tolosa
Run by the Tolosa branch of the Ferroclub Argentino, created in 1996, the Museo Ferroviario "Ing. Pedro C. Saccaggio" is a railway museum in Tolosa.
Héctor Carlos Janson Historic and Numismatics Museum
Run by Argentina's Central Bank, this Buenos Aires museum shows coins, banknotes, medals and documents in the former Stock Exchange building in the San Nicolás district.
Museo de la Inmigración
Housed in the former Immigrants' Hotel in Buenos Aires, the Museo de la Inmigración tells the story of newcomers from Europe, Asia and Africa in the late 19th and early 20th centuries.
Buenos Aires Japanese Gardens
Run by the Japanese Argentine Cultural Foundation, the Buenos Aires Japanese Gardens are a public space ranked among the largest Japanese gardens outside Japan.
Eduardo Sívori Museum
Named after painter Eduardo Sívori, this municipal museum of plastic arts in Buenos Aires opened in 1938.
Frigorífico Anglo del Uruguay
Part of a UNESCO World Heritage landscape inscribed in 2015, the old Anglo meatpacking plant stands on the Uruguay River at Fray Bentos, where frozen meat shipments began in 1924.
Cathedral of Mercedes
Mercedes, Uruguay, centers its Catholic life on the Cathedral of Our Lady of Mercy, which became the seat of the local diocese in 1960.
Agraciada Beach
On the eastern bank of the Uruguay River in Soriano department, Agraciada Beach is a historic beach area facing Argentina's Entre Ríos province.
Anchorena Presidential Estate
Located in Colonia Department, 208 km from Montevideo, the Anchorena Presidential Estate is a national park that also serves as a rest residence for Uruguay's president.
Arriving in Colonia del Sacramento
Basílica del Santísimo Sacramento, Colonia del Sacramento
In Colonia del Sacramento, Uruguay, the Basílica del Santísimo Sacramento (Basilica of the Holy Sacrament) is a Roman Catholic parish church you can stop at in town.
Museo del Origami
Set in the historic district of Colonia del Sacramento, Museo del Origami is a nonprofit museum devoted to the art of paper folding and part of Uruguay's national museum system.
Colonia del Sacramento Lighthouse
Erected in 1857 on the ruins of the Saint Francis Xavier convent, the Colonia del Sacramento Lighthouse stands in the town's historic district in Uruguay.
More drives to Colonia del Sacramento
- Mercedes, Uruguay to Colonia del Sacramento
- Paysandú to Colonia del Sacramento
- Tacuarembó to Colonia del Sacramento
- Salto to Colonia del Sacramento
- Rivera to Colonia del Sacramento
- Artigas to Colonia del Sacramento
More drives from Berisso
- Berisso to Adrogué
- Berisso to Tigre
- Berisso to San Antonio de Areco
- Berisso to Arrecifes
- Berisso to Martínez
- Berisso to Colón, Argentina
Continue Your Adventure
Frequently asked questions
How long does it take to drive from Berisso to Colonia del Sacramento, Uruguay?
About 7 h 22 min of driving without stops, over 336 miles.
How far is Colonia del Sacramento, Uruguay from Berisso by car?
About 336 miles (541 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Where does the Berisso to Colonia del Sacramento drive cross the border?
At about mile 205, from Argentina into Uruguay, at the Gualeguaychú–Fray Bentos bridge.
What do U.S. citizens need to drive from Berisso into Uruguay?
No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. You can drive on your U.S. license. (U.S. State Department, updated August 13, 2026.)
What does the U.S. travel advisory say about the Berisso to Colonia del Sacramento drive?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions; Uruguay Level 2: Exercise Increased Caution. Read the full advisory before you go.
What roads does the drive from Berisso to Colonia del Sacramento use?
In order: 114-05, RN1, AV1-N, RN9, RP6, RN12, RN14 and RN136. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from Berisso to Colonia del Sacramento?
Closest to the road: Héctor Carlos Janson Historic and Numismatics Museum (numismatic museum, mile 39, 0.4 mi from the route); Museo de la Inmigración (migration museum, mile 39, 0.4 mi from the route); Eduardo Sívori Museum (art museum, mile 43, 0.5 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.