Plan on about 11 h 53 min of driving for the 529-mile (851 km) trip from Santa Fe to Río Branco, Uruguay, before any stops. You cross from Argentina into Uruguay at about mile 201, at the Colón–Paysandú bridge.
Full advisory: Argentina, Uruguay. Advisory issued: Argentina July 10, 2026; Uruguay July 28, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers should prepare in advance when taking long road trips and make sure to have adequate insurance coverage.”
- Uruguay: “Several of the main highways are particularly accident-ridden.”
| Distance by road | 529 mi (851 km) |
|---|---|
| Time at the wheel, no stops | 11 h 53 min |
| Main roads, in order | RN168 → RN12 → RP39 → RN14 → RN135 |
| Border crossing | about mile 201, Argentina → Uruguay (the Colón–Paysandú bridge) |
| Regions on the route | Santa Fe, Entre Ríos, Paysandú, Salto, Tacuarembó, Cerro Largo |
| Fuel estimate (car at 25 mpg) | about 21.1 gal; actual use varies by vehicle and traffic |
| Stops listed below | 8 |
Crossing from Argentina into Uruguay
The route crosses at about mile 201, at the Colón–Paysandú bridge, from Entre Ríos into Paysandú. Plan on two checks on each side: immigration for your passport and customs for the car.
| Entering Uruguay (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. |
|---|---|
| Driving in Uruguay | You can drive on your U.S. license. |
| Entering Argentina (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid when you enter; leave a blank page for the entry and exit stamps. |
| Driving in Argentina | A valid U.S. license usually works; an International Driving Permit is recommended. |
| Rental car | Cross only if the rental company authorizes it in writing and gives you the papers for the border; ask before you book. |
Sources: U.S. State Department, Uruguay (updated August 13, 2026); U.S. State Department, Argentina (updated July 16, 2026). Checked October 10, 2026; rules change, so confirm before you go.
On the road from Santa Fe to Río Branco
RN12 (92 mi) and RP39 (63 mi) carry about 29% of the 529 miles. The first 201 miles are in Argentina; the last 328 are in Uruguay. It runs through 6 regions: Santa Fe, Entre Ríos, Paysandú, Salto, Tacuarembó, Cerro Largo. Of the 8 stops listed below, 5 are within a mile of the road.
Which roads connect Santa Fe and Río Branco
| Road | Route miles (from–to) | Length, mi | Region |
|---|---|---|---|
| local roads | 0–2 | 2 | Santa Fe |
| RN168 | 2–19 | 17 | Santa Fe, Entre Ríos |
| connecting roads | 19–20 | 1 | Entre Ríos |
| RN12 | 20–112 | 92 | Entre Ríos |
| RP39 | 112–175 | 63 | Entre Ríos |
| connecting roads | 175–176 | 1 | Entre Ríos |
| RN14 | 176–192 | 16 | Entre Ríos |
| RN135 | 192–200 | 8 | Entre Ríos |
| local roads | 200–474 | 274 | Entre Ríos, Paysandú, Salto, Tacuarembó, Cerro Largo |
| connecting roads | 474–475 | 1 | Cerro Largo |
| local roads | 475–529 | 54 | Cerro Largo |
- Mile 14 of this route: Santa Fe → Entre Ríos (region line)
- Mile 201 of this route: Entre Ríos → Paysandú (international border)
- Mile 309 of this route: Paysandú → Salto (region line)
- Mile 315 of this route: Salto → Paysandú (region line)
- Mile 325 of this route: Paysandú → Tacuarembó (region line)
- Mile 432 of this route: Tacuarembó → Cerro Largo (region line)
Breaking up the drive: stops between Santa Fe and Río Branco
- Right off the route (under 1 mile): Museo Carlos Gardel (mile 331), Museo del Deporte (mile 347), Zoológico Municipal Dr. Mauricio López Lomba (mile 349), Cathedral of Melo (mile 472), Regional History Museum of Melo (mile 472)
- Nature and outdoors: Pozo Hondo (mile 329)
- Museums and history: Paraná Cathedral (mile 16), San José palace (mile 162), Museo Carlos Gardel (mile 331), Museo del Deporte (mile 347), Cathedral of Melo (mile 472), Regional History Museum of Melo (mile 472)
- With kids: Zoológico Municipal Dr. Mauricio López Lomba (mile 349)
Paraná Cathedral
Paraná Cathedral, formally Our Lady of the Rosary Cathedral, is the main Catholic church of Paraná in Entre Ríos Province. It faces the 1 de Mayo Square on San Francisco street, between Urquiza and 25 de Mayo.
San José palace
San José Palace was the home of Justo José de Urquiza, president of the Argentine Confederation from 1854 to 1860, and now houses the Justo José de Urquiza Museum and National Monument.
Pozo Hondo
Pozo Hondo is a waterfall in Uruguay's Tacuarembó department, located between the towns of Valle Edén and Tambores.
Museo Carlos Gardel
Dedicated to the life and work of Carlos Gardel, this museum is in Valle Edén, Tacuarembó department, 21 kilometers from the city of Tacuarembó.
Museo del Deporte
Located in the city of Tacuarembó, Uruguay, the Museo del Deporte preserves and shares the sports history of the Tacuarembó department.
Zoológico Municipal Dr. Mauricio López Lomba
Reachable from Route 5 at kilometer 390, the Mauricio López Lomba reserve is a wildlife reserve in the city of Tacuarembó, Uruguay.
Cathedral of Melo
The Cathedral of Our Lady of the Pillar and St. Raphael is the main Roman Catholic church in the city of Melo, Uruguay.
Regional History Museum of Melo
Founded on June 27, 1976, Melo's municipal history museum displays archaeological pieces and historical items from the region and hosts temporary exhibitions and talks.
More drives to Río Branco
- Rivera to Río Branco
- Montevideo to Río Branco
- Salto to Río Branco
- Paysandú to Río Branco
- Mercedes, Uruguay to Río Branco
- Fray Bentos to Río Branco
More drives from Santa Fe
- Santa Fe to San Nicolás de los Arroyos
- Santa Fe to Tigre
- Santa Fe to Adrogué
- Santa Fe to La Plata
- Santa Fe to Berisso
- Santa Fe to Magdalena
Continue Your Adventure
Frequently asked questions
How long does it take to drive from Santa Fe to Río Branco, Uruguay?
About 11 h 53 min of driving without stops, over 529 miles.
How far is Río Branco, Uruguay from Santa Fe by car?
About 529 miles (851 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Where does the Santa Fe to Río Branco drive cross the border?
At about mile 201, from Argentina into Uruguay, at the Colón–Paysandú bridge.
What do U.S. citizens need to drive from Santa Fe into Uruguay?
No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. You can drive on your U.S. license. (U.S. State Department, updated August 13, 2026.)
What does the U.S. travel advisory say about the Santa Fe to Río Branco drive?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions; Uruguay Level 2: Exercise Increased Caution. Read the full advisory before you go.
Which highways go from Santa Fe to Río Branco?
In order: RN168, RN12, RP39, RN14 and RN135. The road-by-road table above shows the route miles for each one.
What are good stops between Santa Fe and Río Branco?
Closest to the road: Museo Carlos Gardel (museum, mile 331, 0.4 mi from the route); Museo del Deporte (sports museum, mile 347, 0.7 mi from the route); Zoológico Municipal Dr. Mauricio López Lomba (zoo, mile 349, 0.3 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.