By road, Santa Fe and Colón, Argentina are about 198 miles (319 km) apart, or roughly 3 h 53 min of driving.
Full advisory: Argentina. Advisory issued: Argentina July 10, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers should prepare in advance when taking long road trips and make sure to have adequate insurance coverage.”
| Distance by road | 198 mi (319 km) |
|---|---|
| Drive time without stops | 3 h 53 min |
| Main roads, in order | RN168 → RN12 → RP39 → RN14 → RN135 |
| Provinces on the route | Santa Fe, Entre Ríos |
| Fuel estimate (car at 25 mpg) | about 7.9 gal; actual use varies by vehicle and traffic |
| Stops listed below | 2 |
What the drive from Santa Fe to Colón is like
RN12 (92 mi) and RP39 (63 mi) carry about 78% of the 198 miles. It runs through 2 provinces: Santa Fe, Entre Ríos. None of the 2 stops below is right on the road, so plan each as a short side trip.
Roads you'll take from Santa Fe to Colón
| Road | Route miles (from–to) | Length, mi | Province |
|---|---|---|---|
| local roads | 0–2 | 2 | Santa Fe |
| RN168 | 2–19 | 17 | Santa Fe, Entre Ríos |
| connecting roads | 19–20 | 1 | Entre Ríos |
| RN12 | 20–112 | 92 | Entre Ríos |
| RP39 | 112–175 | 63 | Entre Ríos |
| connecting roads | 175–176 | 1 | Entre Ríos |
| RN14 | 176–192 | 16 | Entre Ríos |
| RN135 | 192–197 | 5 | Entre Ríos |
| local roads | 197–198 | 1 | Entre Ríos |
- Mile 14 of this route: Santa Fe → Entre Ríos (province line)
What to see on the way from Santa Fe to Colón
Paraná Cathedral
Paraná Cathedral, formally Our Lady of the Rosary Cathedral, is the main Catholic church of Paraná in Entre Ríos Province. It faces the 1 de Mayo Square on San Francisco street, between Urquiza and 25 de Mayo.
San José palace
San José Palace was the home of Justo José de Urquiza, president of the Argentine Confederation from 1854 to 1860, and now houses the Justo José de Urquiza Museum and National Monument.
More drives to Colón
- Rosario, Argentina to Colón, Argentina
- Buenos Aires to Colón, Argentina
- San Nicolás de los Arroyos to Colón, Argentina
- La Plata to Colón, Argentina
- Berisso to Colón, Argentina
- Mar del Plata to Colón, Argentina
From Santa Fe to other places in Argentina
- Santa Fe to San Nicolás de los Arroyos
- Santa Fe to Tigre
- Santa Fe to Adrogué
- Santa Fe to La Plata
- Santa Fe to Berisso
- Santa Fe to Magdalena
Continue Your Adventure
Frequently asked questions
How long does it take to drive from Santa Fe to Colón, Argentina?
About 3 h 53 min of driving without stops, over 198 miles.
How far is Colón, Argentina from Santa Fe by car?
About 198 miles (319 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the Santa Fe to Colón drive?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions. Read the full advisory before you go.
What roads does the drive from Santa Fe to Colón use?
In order: RN168, RN12, RP39, RN14 and RN135. The road-by-road table above shows the route miles for each one.
What are good stops between Santa Fe and Colón?
Closest to the road: Paraná Cathedral (cathedral, mile 16, 2 mi from the route); San José palace (museum, mile 162, 2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.