By road, Santa Fe and Posadas are about 482 miles (776 km) apart, or roughly 10 h 46 min of driving.
Full advisory: Argentina. Advisory issued: Argentina July 10, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Gas stations are often far apart and not always easily identified from the main roadway.”
| Total distance | 482 mi (776 km) |
|---|---|
| Drive time without stops | 10 h 46 min |
| Main roads, in order | RN168 → RN12 → RN127 → RN14 → RN105 |
| Provinces on the route | Santa Fe, Entre Ríos, Corrientes, Misiones |
| Fuel estimate (car at 25 mpg) | about 19.3 gal; actual use varies by vehicle and traffic |
| Stops listed below | 5 |
On the road from Santa Fe to Posadas
RN14 (236 mi) and RN127 (115 mi) carry about 73% of the 482 miles. It runs through 4 provinces: Santa Fe, Entre Ríos, Corrientes, Misiones. Of the 5 stops listed below, 2 are within a mile of the road.
Road-by-road breakdown: Santa Fe to Posadas
| Road | Route miles (from–to) | Length, mi | Province |
|---|---|---|---|
| local roads | 0–2 | 2 | Santa Fe |
| RN168 | 2–24 | 22 | Santa Fe, Entre Ríos |
| RN12 | 24–101 | 77 | Entre Ríos |
| RN127 | 101–216 | 115 | Entre Ríos, Corrientes |
| connecting roads | 216–217 | 1 | Corrientes |
| RN14 | 217–453 | 236 | Corrientes, Misiones |
| RN105 | 453–480 | 27 | Misiones |
| local roads | 480–482 | 2 | Misiones |
- Mile 14 of this route: Santa Fe → Entre Ríos (province line)
- Mile 198 of this route: Entre Ríos → Corrientes (province line)
- Mile 448 of this route: Corrientes → Misiones (province line)
Breaking up the drive: stops between Santa Fe and Posadas
- Right off the route (under 1 mile): Museo Provincial San Ignacio de Loyola (mile 452), Mission San José de Itacuá (mile 452)
- Museums and history: Paraná Cathedral (mile 16), Mission Nuestra Señora de la Asunción de Acaraguá y Mbororé (mile 328), Museo Provincial San Ignacio de Loyola (mile 452), Mission San José de Itacuá (mile 452)
Paraná Cathedral
Paraná Cathedral, formally Our Lady of the Rosary Cathedral, is the main Catholic church of Paraná in Entre Ríos Province. It faces the 1 de Mayo Square on San Francisco street, between Urquiza and 25 de Mayo.
Mission Nuestra Señora de la Asunción de Acaraguá y Mbororé
In the town of La Cruz, Corrientes, Mission Nuestra Señora de la Asunción de Acaraguá y Mbororé was one of the missions the Jesuits founded in their Province of Paraguay during Spanish colonial rule.
Museo Provincial San Ignacio de Loyola
Built in 1895, Museo Provincial San Ignacio de Loyola stands at the corner of Centenario and 9 de Julio avenues in San José.
Mission San José de Itacuá
Remains of the Jesuit mission of San José de Itacuá lie outside the town of San José in Misiones. Founded by José Cataldino in 1633, it was refounded in 1660 and destroyed in 1817.
Parque ecológico Candelaria
Near the town of Candelaria in southern Misiones, the Parque ecológico Candelaria was created for wildlife conservation, environmental education and recreational tourism.
Once you reach Posadas
Museum of Natural Sciences and History Antonio Ruiz de Montoya
In Posadas, Argentina, this natural sciences and history museum belongs to the Instituto Superior Antonio Ruiz de Montoya, a college founded in 1960 by Monsignor Jorge Kemerer.
Posadas Cathedral
St. Joseph's Cathedral, also called Posadas Cathedral, is the main Catholic church of Posadas, capital of Misiones province.
Anibal Cambas Regional Museum
In Posadas, the Aníbal Cambas Regional Museum (Museo Regional Aníbal Cambas) has been open for 75 years, making it the oldest museum in the capital of Misiones.
More drives to Posadas
From Santa Fe to other places in Argentina
- Santa Fe to San Nicolás de los Arroyos
- Santa Fe to Tigre
- Santa Fe to Adrogué
- Santa Fe to La Plata
- Santa Fe to Berisso
- Santa Fe to Magdalena
Continue Your Adventure
Frequently asked questions
How long is the drive from Santa Fe to Posadas?
About 10 h 46 min of driving without stops, over 482 miles.
What is the driving distance from Santa Fe to Posadas?
About 482 miles (776 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from Santa Fe to Posadas?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions. Read the full advisory before you go.
What roads does the drive from Santa Fe to Posadas use?
In order: RN168, RN12, RN127, RN14 and RN105. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from Santa Fe to Posadas?
Closest to the road: Paraná Cathedral (cathedral, mile 16, 2 mi from the route); Museo Provincial San Ignacio de Loyola (museum, mile 452, 0.9 mi from the route); Mission San José de Itacuá (jesuit mission ruins, mile 452, 0.9 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.