The Wayro route from Santa Fe to Ituzaingó is 470 miles (756 km), about 9 h 45 min of driving without stops.
Full advisory: Argentina. Advisory issued: Argentina July 10, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers should prepare in advance when taking long road trips and make sure to have adequate insurance coverage.”
| Distance by road | 470 mi (756 km) |
|---|---|
| Drive time without stops | 9 h 45 min |
| Main roads, in order | RN168 → RN12 → RP27 → RN118 |
| Provinces on the route | Santa Fe, Entre Ríos, Corrientes |
| Fuel estimate (car at 25 mpg) | about 18.8 gal; actual use varies by vehicle and traffic |
| Stops listed below | 3 |
Driving Santa Fe to Ituzaingó: the shape of the trip
RN12 (244 mi) and RN118 (121 mi) carry about 78% of the 470 miles. It runs through 3 provinces: Santa Fe, Entre Ríos, Corrientes. None of the 3 stops below is right on the road, so plan each as a short side trip.
Road-by-road breakdown: Santa Fe to Ituzaingó
| Road | Route miles (from–to) | Length, mi | Province |
|---|---|---|---|
| local roads | 0–2 | 2 | Santa Fe |
| RN168 | 2–24 | 22 | Santa Fe, Entre Ríos |
| RN12 | 24–237 | 213 | Entre Ríos, Corrientes |
| RP27 | 237–316 | 79 | Corrientes |
| RN118 | 316–437 | 121 | Corrientes |
| RN12 | 437–468 | 31 | Corrientes |
| local roads | 468–470 | 2 | Corrientes |
- Mile 14 of this route: Santa Fe → Entre Ríos (province line)
- Mile 148 of this route: Entre Ríos → Corrientes (province line)
Places worth a stop between Santa Fe and Ituzaingó
- Nature and outdoors: Iberá National Park (mile 321), Mburucuyá National Park (mile 372)
- Museums and history: Paraná Cathedral (mile 16)
Paraná Cathedral
Paraná Cathedral, formally Our Lady of the Rosary Cathedral, is the main Catholic church of Paraná in Entre Ríos Province. It faces the 1 de Mayo Square on San Francisco street, between Urquiza and 25 de Mayo.
Iberá National Park
In the northeastern province of Corrientes, Iberá National Park borders the 5,530 square-kilometer Iberá Provincial Park to the southeast.
Mburucuyá National Park
Mburucuyá National Park covers 176 square kilometers of the Iberá Wetlands in northwest Corrientes Province, about 150 kilometers from the city of Corrientes.
More drives to Ituzaingó
- Ciudad del Este to Ituzaingó, Argentina
- Porto Alegre to Ituzaingó, Argentina
- Caxias do Sul to Ituzaingó, Argentina
- Pelotas to Ituzaingó, Argentina
- Santa Maria, Brazil to Ituzaingó, Argentina
- São Leopoldo to Ituzaingó, Argentina
From Santa Fe to other places in Argentina
- Santa Fe to San Nicolás de los Arroyos
- Santa Fe to Tigre
- Santa Fe to Adrogué
- Santa Fe to La Plata
- Santa Fe to Berisso
- Santa Fe to Magdalena
Continue Your Adventure
Frequently asked questions
How long is the drive from Santa Fe to Ituzaingó?
About 9 h 45 min of driving without stops, over 470 miles.
What is the driving distance from Santa Fe to Ituzaingó?
About 470 miles (756 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the Santa Fe to Ituzaingó drive?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions. Read the full advisory before you go.
What roads does the drive from Santa Fe to Ituzaingó use?
In order: RN168, RN12, RP27 and RN118. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from Santa Fe to Ituzaingó?
Closest to the road: Paraná Cathedral (cathedral, mile 16, 2 mi from the route); Iberá National Park (national park, mile 321, 2 mi from the route); Mburucuyá National Park (national park of Argentina, mile 372, 11 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.