Santa Fe to Durazno, Uruguay is about 345 road miles (556 km): roughly 7 h 2 min at the wheel if you don't stop. You cross from Argentina into Uruguay at about mile 201, at the Colón–Paysandú bridge.
Full advisory: Argentina, Uruguay. Advisory issued: Argentina July 10, 2026; Uruguay July 28, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers should prepare in advance when taking long road trips and make sure to have adequate insurance coverage.”
- Uruguay: “Several of the main highways are particularly accident-ridden.”
| Total distance | 345 mi (556 km) |
|---|---|
| Driving time, no stops | 7 h 2 min |
| Main roads, in order | RN168 → RN12 → RP39 → RN14 → RN135 |
| Border crossing | about mile 201, Argentina → Uruguay (the Colón–Paysandú bridge) |
| Regions on the route | Santa Fe, Entre Ríos, Paysandú, Río Negro, Flores, Durazno |
| Fuel estimate (car at 25 mpg) | about 13.8 gal; actual use varies by vehicle and traffic |
| Stops listed below | 4 |
Crossing from Argentina into Uruguay
The route crosses at about mile 201, at the Colón–Paysandú bridge, from Entre Ríos into Paysandú. Plan on two checks on each side: immigration for your passport and customs for the car.
| Entering Uruguay (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. |
|---|---|
| Driving in Uruguay | You can drive on your U.S. license. |
| Entering Argentina (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid when you enter; leave a blank page for the entry and exit stamps. |
| Driving in Argentina | A valid U.S. license usually works; an International Driving Permit is recommended. |
| Rental car | Cross only if the rental company authorizes it in writing and gives you the papers for the border; ask before you book. |
Sources: U.S. State Department, Uruguay (updated August 13, 2026); U.S. State Department, Argentina (updated July 16, 2026). Checked October 10, 2026; rules change, so confirm before you go.
The Santa Fe–Durazno drive in a few lines
RN12 (92 mi) and RP39 (63 mi) carry about 45% of the 345 miles. The first 201 miles are in Argentina; the last 144 are in Uruguay. It runs through 6 regions: Santa Fe, Entre Ríos, Paysandú, Río Negro, Flores, Durazno. Of the 4 stops listed below, 1 are within a mile of the road.
Which roads connect Santa Fe and Durazno
| Road | Route miles (from–to) | Length, mi | Region |
|---|---|---|---|
| local roads | 0–2 | 2 | Santa Fe |
| RN168 | 2–19 | 17 | Santa Fe, Entre Ríos |
| connecting roads | 19–20 | 1 | Entre Ríos |
| RN12 | 20–112 | 92 | Entre Ríos |
| RP39 | 112–175 | 63 | Entre Ríos |
| connecting roads | 175–176 | 1 | Entre Ríos |
| RN14 | 176–192 | 16 | Entre Ríos |
| RN135 | 192–200 | 8 | Entre Ríos |
| local roads | 200–345 | 145 | Entre Ríos, Paysandú, Río Negro, Flores, Durazno |
- Mile 14 of this route: Santa Fe → Entre Ríos (region line)
- Mile 201 of this route: Entre Ríos → Paysandú (international border)
- Mile 234 of this route: Paysandú → Río Negro (region line)
- Mile 289 of this route: Río Negro → Flores (region line)
- Mile 341 of this route: Flores → Durazno (region line)
Breaking up the drive: stops between Santa Fe and Durazno
- Right off the route (under 1 mile): Reserva de Flora y fauna Dr. Rodolfo Tálice (mile 318)
- Nature and outdoors: Reserva de Flora y fauna Dr. Rodolfo Tálice (mile 318)
- Museums and history: Paraná Cathedral (mile 16), San José palace (mile 162), Nuestra Señora del Rosario y San Benito de Palermo, Paysandú (mile 208)
Paraná Cathedral
Paraná Cathedral, formally Our Lady of the Rosary Cathedral, is the main Catholic church of Paraná in Entre Ríos Province. It faces the 1 de Mayo Square on San Francisco street, between Urquiza and 25 de Mayo.
San José palace
San José Palace was the home of Justo José de Urquiza, president of the Argentine Confederation from 1854 to 1860, and now houses the Justo José de Urquiza Museum and National Monument.
Nuestra Señora del Rosario y San Benito de Palermo, Paysandú
Paysandú's Catholic parish church of Our Lady of the Rosary and St. Benedict of Palermo was named a minor basilica in 1949 and remains an active parish of the city.
Reserva de Flora y fauna Dr. Rodolfo Tálice
Off Route 3 near Trinidad, the Dr. Rodolfo Tálice Ecopark (Reserva de Flora y Fauna Dr. Rodolfo Talice) is a fenced wildlife reserve where axis deer, greater rheas and pampas deer roam free alongside other species.
Once you reach Durazno
Casa de Rivera, Durazno
Facing Plaza Independencia in Durazno, the Casa de Fructuoso Rivera (Casa de Rivera) is one of the town's main heritage sites and now houses the department's historical museum.
More drives to Durazno
- Montevideo to Durazno
- Maldonado to Durazno
- Artigas to Durazno
- Buenos Aires to Durazno, Uruguay
- Rosario, Argentina to Durazno, Uruguay
- Mar del Plata to Durazno, Uruguay
More drives from Santa Fe
- Santa Fe to San Nicolás de los Arroyos
- Santa Fe to Tigre
- Santa Fe to Adrogué
- Santa Fe to La Plata
- Santa Fe to Berisso
- Santa Fe to Magdalena
Continue Your Adventure
Frequently asked questions
How long is the drive from Santa Fe to Durazno, Uruguay?
About 7 h 2 min of driving without stops, over 345 miles.
How far is Durazno, Uruguay from Santa Fe by car?
About 345 miles (556 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Where does the Santa Fe to Durazno drive cross the border?
At about mile 201, from Argentina into Uruguay, at the Colón–Paysandú bridge.
What do U.S. citizens need to drive from Santa Fe into Uruguay?
No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. You can drive on your U.S. license. (U.S. State Department, updated August 13, 2026.)
Is it safe to drive from Santa Fe to Durazno, Uruguay?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions; Uruguay Level 2: Exercise Increased Caution. Read the full advisory before you go.
What roads does the drive from Santa Fe to Durazno use?
In order: RN168, RN12, RP39, RN14 and RN135. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from Santa Fe to Durazno?
Closest to the road: Paraná Cathedral (cathedral, mile 16, 2 mi from the route); San José palace (museum, mile 162, 2 mi from the route); Reserva de Flora y fauna Dr. Rodolfo Tálice (botanical garden, mile 318, 0.2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.