Plan on about 10 h 54 min of driving for the 545-mile (877 km) trip from Santa Fe to Areguá, Paraguay, before any stops. You cross from Argentina into Paraguay at about mile 521, at Clorinda–José Falcón.
Full advisory: Argentina, Paraguay. Advisory issued: Argentina July 10, 2026; Paraguay August 19, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers should prepare in advance when taking long road trips and make sure to have adequate insurance coverage.”
- Paraguay: “Nearly all rural roads are unpaved and may be impassable during rainy periods and the rainy season from October to March.”
| Total distance | 545 mi (877 km) |
|---|---|
| Time at the wheel, no stops | 10 h 54 min |
| Main roads, in order | RNA007 → RN11 → PY09 → D075 → D023 |
| Border crossing | about mile 521, Argentina → Paraguay (Clorinda–José Falcón) |
| Regions on the route | Santa Fe, Chaco, Formosa, Presidente Hayes, Central |
| Fuel estimate (car at 25 mpg) | about 21.8 gal; actual use varies by vehicle and traffic |
| Stops listed below | 6 |
The border on the way to Areguá
The route crosses at about mile 521, at Clorinda–José Falcón, from Formosa into Presidente Hayes. Plan on two checks on each side: immigration for your passport and customs for the car.
| Entering Paraguay (U.S. citizens) | No visa needed for stays of up to 90 days. Passport: must be valid for 6 months beyond your arrival date. |
|---|---|
| Driving in Paraguay | You need a valid U.S. license and a valid International Driving Permit. |
| Entering Argentina (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid when you enter; leave a blank page for the entry and exit stamps. |
| Driving in Argentina | A valid U.S. license usually works; an International Driving Permit is recommended. |
| The car, entering Paraguay | The State Department notes that Paraguay doesn't require vehicle insurance. |
| Rental car | Cross only if the rental company authorizes it in writing and gives you the papers for the border; ask before you book. |
Sources: U.S. State Department, Paraguay (updated September 17, 2026); U.S. State Department, Argentina (updated July 16, 2026). Checked October 10, 2026; rules change, so confirm before you go.
How the Santa Fe to Areguá drive plays out
RN11 (499 mi) and RNA007 (20 mi) carry about 95% of the 545 miles. The first 521 miles are in Argentina; the last 24 are in Paraguay. It runs through 5 regions: Santa Fe, Chaco, Formosa, Presidente Hayes, Central. Of the 6 stops listed below, 2 are within a mile of the road.
Santa Fe to Areguá: the road sequence
| Road | Route miles (from–to) | Length, mi | Region |
|---|---|---|---|
| local roads | 0–1 | 1 | Santa Fe |
| RNA007 | 1–21 | 20 | Santa Fe |
| RN11 | 21–520 | 499 | Santa Fe, Chaco, Formosa |
| PY09 | 520–528 | 8 | Formosa, Presidente Hayes |
| D075 | 528–534 | 6 | Presidente Hayes |
| D023 | 534–545 | 11 | Presidente Hayes, Central |
- Mile 295 of this route: Santa Fe → Chaco (region line)
- Mile 403 of this route: Chaco → Formosa (region line)
- Mile 521 of this route: Formosa → Presidente Hayes (international border)
- Mile 535 of this route: Presidente Hayes → Central (region line)
What to see on the way from Santa Fe to Areguá
- Right off the route (under 1 mile): Botanical Garden and Zoo of Asunción (mile 534), Museo del Fútbol Sudamericano (mile 537)
- Nature and outdoors: Botanical Garden and Zoo of Asunción (mile 534)
- Museums and history: Resistencia Cathedral (mile 341), Regional Museum of Anthropology "Juan Alfredo Martinet" (mile 341), Our Lady of Carmel Cathedral, Formosa (mile 447), Museo del Barro (mile 535), Museo del Fútbol Sudamericano (mile 537)
- With kids: Botanical Garden and Zoo of Asunción (mile 534)
Resistencia Cathedral
Also called the St. Ferdinand the King Cathedral, Resistencia Cathedral is the Roman Catholic cathedral of the city of Resistencia, Argentina.
Regional Museum of Anthropology "Juan Alfredo Martinet"
In Resistencia, the Juan Alfredo Martinet Regional Museum of Anthropology introduces the roots of the Chaco region and its people; it grew out of archaeological research at the Km 75 site in Chaco.
Our Lady of Carmel Cathedral, Formosa
Also known as Formosa Cathedral, Our Lady of Carmel Cathedral is a Catholic cathedral in the city of Formosa and the seat of the Diocese of Formosa.
Botanical Garden and Zoo of Asunción
Set in natural forest covering 272 acres north of the city, the Botanical Garden and Zoo of Asunción combines a botanical garden and a zoo in Paraguay's capital.
Museo del Barro
On the outskirts of Asunción, Museo del Barro began as a private traveling collection and found a permanent home after seven years.
Museo del Fútbol Sudamericano
At Conmebol's headquarters in Luque, the Museo del Fútbol Sudamericano opened in 2009 and shows over 1,800 objects on the history of South American soccer across three halls.
In Areguá itself
Ypacaraí Lake
Roughly 50 km east of Asunción, Ypacaraí Lake is a major body of water in Paraguay that drains northwest through the Salado River into the Paraguay River.
More drives to Areguá
- Encarnación to Areguá
- Pedro Juan Caballero to Areguá
- Corrientes to Areguá, Paraguay
- Resistencia to Areguá, Paraguay
- Paraná to Areguá, Paraguay
- Formosa, Argentina to Areguá, Paraguay
More drives from Santa Fe
- Santa Fe to San Nicolás de los Arroyos
- Santa Fe to Tigre
- Santa Fe to Adrogué
- Santa Fe to La Plata
- Santa Fe to Berisso
- Santa Fe to Magdalena
Continue Your Adventure
Frequently asked questions
How long is the drive from Santa Fe to Areguá, Paraguay?
About 10 h 54 min of driving without stops, over 545 miles.
What is the driving distance from Santa Fe to Areguá, Paraguay?
About 545 miles (877 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Where does the Santa Fe to Areguá drive cross the border?
At about mile 521, from Argentina into Paraguay, at Clorinda–José Falcón.
What do U.S. citizens need to drive from Santa Fe into Paraguay?
No visa needed for stays of up to 90 days. Passport: must be valid for 6 months beyond your arrival date. You need a valid U.S. license and a valid International Driving Permit. (U.S. State Department, updated September 17, 2026.)
What does the U.S. travel advisory say about the Santa Fe to Areguá drive?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions; Paraguay Level 1: Exercise Normal Precautions. Read the full advisory before you go.
Which highways go from Santa Fe to Areguá?
In order: RNA007, RN11, PY09, D075 and D023. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from Santa Fe to Areguá?
Closest to the road: Botanical Garden and Zoo of Asunción (botanical garden, mile 534, 0.5 mi from the route); Museo del Barro (museum, mile 535, 2 mi from the route); Museo del Fútbol Sudamericano (museum, mile 537, 0.1 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.