Plan on about 3 h 28 min of driving for the 140-mile (226 km) trip from San Miguel de Tucumán to Cafayate, before any stops.
Full advisory: Argentina. Advisory issued: Argentina July 10, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers should prepare in advance when taking long road trips and make sure to have adequate insurance coverage.”
| Distance by road | 140 mi (226 km) |
|---|---|
| Time at the wheel, no stops | 3 h 28 min |
| Main roads, in order | RN38 → RP307 → RP357 → RN40 |
| Provinces on the route | Tucumán, Salta |
| Fuel estimate (car at 25 mpg) | about 5.6 gal; actual use varies by vehicle and traffic |
| Stops listed below | 5 |
On the road from San Miguel de Tucumán to Cafayate
RP307 (69 mi) and RN40 (32 mi) carry about 72% of the 140 miles. It runs through 2 provinces: Tucumán, Salta. Of the 5 stops listed below, 2 are within a mile of the road.
Which roads connect San Miguel de Tucumán and Cafayate
| Road | Route miles (from–to) | Length, mi | Province |
|---|---|---|---|
| local roads | 0–4 | 4 | Tucumán |
| connecting roads | 4–6 | 2 | Tucumán |
| RN38 | 6–30 | 24 | Tucumán |
| RP307 | 30–99 | 69 | Tucumán |
| RP357 | 99–108 | 9 | Tucumán |
| RN40 | 108–140 | 32 | Tucumán, Salta |
- Mile 126 of this route: Tucumán → Salta (province line)
Where to stop on the way to Cafayate
- Right off the route (under 1 mile): Reserva provincial La Angostura (mile 62), Museo Pachamama (mile 100)
- Nature and outdoors: Aconquija National Park (mile 43), Reserva arqueológica Los Menhires (mile 54), Reserva provincial La Angostura (mile 62)
- Museums and history: Museo Pachamama (mile 100), Ruins of Quilmes (mile 110)
Aconquija National Park
Established on August 9, 1995 in Tucumán Province, Aconquija National Park protects a representative sample of Southern Andean Yungas montane forest. It was formerly called Campo de los Alisos National Park.
Reserva arqueológica Los Menhires
Near El Mollar in Tafí del Valle, the Los Menhires archaeological reserve displays granite standing stones carved and moved by local inhabitants some 2,000 years ago, facing the La Angostura reservoir.
Reserva provincial La Angostura
Near the town of El Mollar in Tafí del Valle department, Tucumán, La Angostura is a strict provincial nature reserve.
Museo Pachamama
Museo Pachamama, in the Tucumán town of Amaicha del Valle, displays characteristic features of the Calchaquí Valleys.
Ruins of Quilmes
In the Calchaquí Valleys of Tucumán Province, the Ruins of Quilmes mark a pre-Columbian settlement that covered about 74 acres, the largest in the country.
Arriving in Cafayate
Our Lady of Rosary Cathedral, Cafayate
In the town of Cafayate, Salta Province, Our Lady of Rosary Cathedral is the seat of the Catholic bishopric of Cafayate, under the Archdiocese of Salta.
Museo de la Vid y el Vino
In Cafayate, Salta Province, the Museo de la Vid y el Vino is a museum devoted to grapevines and winemaking.
More drives to Cafayate
- Córdoba, Argentina to Cafayate
- Tafí Viejo to Cafayate
- La Quiaca to Cafayate
- Tupiza to Cafayate, Argentina
- Uyuni to Cafayate, Argentina
From San Miguel de Tucumán to other places in Argentina
- San Miguel de Tucumán to San Agustín de Valle Fértil
- San Miguel de Tucumán to Villa Unión
- San Miguel de Tucumán to Río Cuarto
- San Miguel de Tucumán to Paraná
- San Miguel de Tucumán to Amaicha del Valle
- San Miguel de Tucumán to San Antonio de los Cobres
Frequently asked questions
How long is the drive from San Miguel de Tucumán to Cafayate?
About 3 h 28 min of driving without stops, over 140 miles.
What is the driving distance from San Miguel de Tucumán to Cafayate?
About 140 miles (226 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the San Miguel de Tucumán to Cafayate drive?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions. Read the full advisory before you go.
Which highways go from San Miguel de Tucumán to Cafayate?
In order: RN38, RP307, RP357 and RN40. The road-by-road table above shows the route miles for each one.
What are good stops between San Miguel de Tucumán and Cafayate?
Closest to the road: Reserva provincial La Angostura (park, mile 62, 0.9 mi from the route); Museo Pachamama (museum, mile 100, 0.3 mi from the route); Ruins of Quilmes (archaeological site, mile 110, 3 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.