The Wayro route from La Quiaca to Cafayate is 365 miles (587 km), about 8 h 11 min of driving without stops.
Full advisory: Argentina. Advisory issued: Argentina July 10, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers should prepare in advance when taking long road trips and make sure to have adequate insurance coverage.”
| Distance | 365 mi (587 km) |
|---|---|
| Drive time without stops | 8 h 11 min |
| Main roads, in order | RN9 → RN66 → RN1V66 → RN34 → RP59 → RN68 |
| Provinces on the route | Jujuy, Salta |
| Fuel estimate (car at 25 mpg) | about 14.6 gal; actual use varies by vehicle and traffic |
| Stops listed below | 6 |
On the road from La Quiaca to Cafayate
RN9 (200 mi) and RN68 (108 mi) carry about 84% of the 365 miles. It runs through 2 provinces: Jujuy, Salta. Of the 6 stops listed below, 3 are within a mile of the road.
Road-by-road breakdown: La Quiaca to Cafayate
| Road | Route miles (from–to) | Length, mi | Province |
|---|---|---|---|
| RN9 | 0–177 | 177 | Jujuy |
| RN66 | 177–193 | 16 | Jujuy |
| RN1V66 | 193–200 | 7 | Jujuy |
| RN34 | 200–221 | 21 | Jujuy, Salta |
| RN9 | 221–244 | 23 | Salta |
| connecting roads | 244–246 | 2 | Salta |
| RP59 | 246–250 | 4 | Salta |
| connecting roads | 250–256 | 6 | Salta |
| RN68 | 256–364 | 108 | Salta |
| local roads | 364–365 | 1 | Salta |
- Mile 206 of this route: Jujuy → Salta (province line)
Breaking up the drive: stops between La Quiaca and Cafayate
- Right off the route (under 1 mile): José Antonio Terry Regional Museum of Painting (mile 124), Pucará de Tilcara (mile 125), Posta de Hornillos (mile 130)
- Museums and history: José Antonio Terry Regional Museum of Painting (mile 124), Pucará de Tilcara (mile 125), Posta de Hornillos (mile 130), Museo Juan Galo Lavalle (mile 173), Cathedral Basilica of the Holy Saviour, San Salvador de Jujuy (mile 174), Salta Cathedral (mile 245)
José Antonio Terry Regional Museum of Painting
On Rivadavia street in Tilcara, Jujuy, the Museo Nacional Terry occupies the colonial-style house where painter José Antonio Terry lived and focuses on his paintings.
Pucará de Tilcara
On a hill just outside Tilcara in Jujuy, the Pucará de Tilcara is a pre-Inca fortification placed for easy defense and good views over a long stretch of the Quebrada de Humahuaca.
Posta de Hornillos
Dating from the colonial era, the Posta de Hornillos is a former relay post in the Quebrada de Humahuaca, Tilcara department, that has worked as a history museum since 1979.
Museo Juan Galo Lavalle
Inside a mid-18th-century house declared a National Historic Monument, this provincial history museum marks the place where independence-era leader Juan Galo Lavalle was killed.
Cathedral Basilica of the Holy Saviour, San Salvador de Jujuy
The Cathedral Basilica of the Holy Saviour is the seat of the Catholic bishopric of San Salvador de Jujuy and is counted among Argentina's historic buildings.
Salta Cathedral
Salta Cathedral is a Roman Catholic cathedral in Salta and serves as the seat and metropolitan cathedral of the Archbishop of Salta.
In Cafayate itself
Our Lady of Rosary Cathedral, Cafayate
In the town of Cafayate, Salta Province, Our Lady of Rosary Cathedral is the seat of the Catholic bishopric of Cafayate, under the Archdiocese of Salta.
Museo de la Vid y el Vino
In Cafayate, Salta Province, the Museo de la Vid y el Vino is a museum devoted to grapevines and winemaking.
More drives to Cafayate
- San Miguel de Tucumán to Cafayate
- Córdoba, Argentina to Cafayate
- Tafí Viejo to Cafayate
- Tupiza to Cafayate, Argentina
- Uyuni to Cafayate, Argentina
From La Quiaca to other places in Argentina
- La Quiaca to Tarata, Bolivia
- La Quiaca to Quime, Bolivia
- La Quiaca to San Pedro de Quemes Canton, Bolivia
Frequently asked questions
How long does it take to drive from La Quiaca to Cafayate?
About 8 h 11 min of driving without stops, over 365 miles.
What is the driving distance from La Quiaca to Cafayate?
About 365 miles (587 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from La Quiaca to Cafayate?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions. Read the full advisory before you go.
Which highways go from La Quiaca to Cafayate?
In order: RN9, RN66, RN1V66, RN34, RP59 and RN68. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from La Quiaca to Cafayate?
Closest to the road: José Antonio Terry Regional Museum of Painting (historic house museum, mile 124, 0.4 mi from the route); Pucará de Tilcara (fortress, mile 125, 0.3 mi from the route); Posta de Hornillos (museum, mile 130, 0.1 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.