Driving from Melo to Colonia del Sacramento: 355 miles, roughly 7 h 49 min without stops. Road by road, 9 places to stop and the State Department advisory.
Plan the Melo to Fray Bentos road trip: 324 miles (521 km), 7 h 56 min of driving, 3 stops along the way and what the U.S. advisory says about Uruguay.