Plan the Cali to Ibarra, Ecuador drive: 388 miles (624 km), 11 h 43 min without stops, the border crossing, U.S. travel advisory and 5 stops.

Driving from Cali to Ambato, Ecuador: 545 miles and about 15 h 29 min behind the wheel. Where you cross into Ecuador, what to bring, and 7 stops on the way.

Cali to Santo Domingo de los Colorados, Ecuador: 551 miles (887 km), about 15 h 41 min of driving with one border crossing. Entry rules for Ecuador, State.

Driving from Quito to Cali, Colombia: 450 miles and about 13 h 25 min behind the wheel. Where you cross into Colombia, what to bring, and 7 stops on the way.

Fray Bentos to Río Branco: 434 miles (698 km), about 9 h 16 min of driving. The route, U.S. travel advisory for Uruguay and 9 stops on the way.

Driving from Mercedes, Uruguay to Río Branco: 413 miles, roughly 8 h 46 min without stops. Road by road, 8 places to stop and the State Department advisory.

5 stops between Paysandú and Río Branco, plus the route: 328 miles (528 km), about 8 h 2 min of driving and the U.S. travel advisory level.

3 stops between Salto and Río Branco, plus the route: 318 miles (511 km), about 8 h 29 min of driving and the U.S. travel advisory level.

8 stops between Montevideo and Río Branco, plus the route: 255 miles (411 km), about 5 h 38 min of driving and the U.S. travel advisory level.

Rivera to Río Branco: 245 miles (394 km), about 5 h 39 min of driving. The route, U.S. travel advisory for Uruguay and 4 stops on the way.