Plan on about 8 h 23 min of driving for the 420-mile (676 km) trip from Neuquén to Puerto Madryn, before any stops.
Full advisory: Argentina. Advisory issued: Argentina July 10, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers should prepare in advance when taking long road trips and make sure to have adequate insurance coverage.”
| Total distance | 420 mi (676 km) |
|---|---|
| Driving time, no stops | 8 h 23 min |
| Main roads, in order | RN22 → RN250 → RP2 → RN3 |
| Provinces on the route | Neuquén, Río Negro, Chubut |
| Fuel estimate (car at 25 mpg) | about 16.8 gal; actual use varies by vehicle and traffic |
| Stops listed below | 3 |
How the Neuquén to Puerto Madryn drive plays out
RN3 (159 mi) and RN22 (133 mi) carry about 70% of the 420 miles. It runs through 3 provinces: Neuquén, Río Negro, Chubut. Of the 3 stops listed below, 1 are within a mile of the road.
Road-by-road breakdown: Neuquén to Puerto Madryn
| Road | Route miles (from–to) | Length, mi | Province |
|---|---|---|---|
| local roads | 0–7 | 7 | Neuquén, Río Negro |
| RN22 | 7–140 | 133 | Río Negro |
| RN250 | 140–198 | 58 | Río Negro |
| RP2 | 198–255 | 57 | Río Negro |
| RN3 | 255–414 | 159 | Río Negro, Chubut |
| local roads | 414–420 | 6 | Chubut |
- Mile 2 of this route: Neuquén → Río Negro (province line)
- Mile 361 of this route: Río Negro → Chubut (province line)
Places worth a stop between Neuquén and Puerto Madryn
- Right off the route (under 1 mile): Museo Patagónico de Ciencias Naturales Juan Carlos Salgado (mile 28)
- Nature and outdoors: Museo Patagónico de Ciencias Naturales Juan Carlos Salgado (mile 28), Área natural protegida Bahía de San Antonio (mile 258)
- Museums and history: Estación Cultural Lucinda Larrosa Museum (mile 8), Museo Patagónico de Ciencias Naturales Juan Carlos Salgado (mile 28)
Estación Cultural Lucinda Larrosa Museum
Beside provincial route 65 in General Fernández Oro, Río Negro, this museum and cultural center started as an archaeological and regional history museum and now hosts rotating art exhibitions.
Museo Patagónico de Ciencias Naturales Juan Carlos Salgado
In General Roca, Río Negro, the Museo Patagónico de Ciencias Naturales Juan Carlos Salgado is a natural sciences museum noted for its scientific contributions and heritage collections.
Área natural protegida Bahía de San Antonio
On the San Matías Gulf in Argentina's Río Negro province, the Bahía de San Antonio protected area was set up in 1993 to safeguard a seabird breeding zone and a stopover for migratory birds.
In Puerto Madryn itself
Golfo Nuevo Lighthouse
Just north of Puerto Madryn on the Golfo Nuevo, this unstaffed Argentine Navy lighthouse (Faro Golfo Nuevo) has been in service since June 1917.
Provincial Museum of Natural and Oceanographic Sciences
Located in central Puerto Madryn, Argentina, this provincial museum of natural and oceanographic sciences currently presents an exhibit titled El hombre y el mar (Man and the Sea).
Museo del Desembarco
Museo del Desembarco is a museum located on the south side of the city of Puerto Madryn, Argentina.
From Neuquén to other places in Argentina
- Neuquén to San Antonio Oeste
- Neuquén to Santa Rosa
- Neuquén to Balneario El Cóndor
- Neuquén to Sierra de La Ventana
- Neuquén to Rawson
- Neuquén to Necochea
Frequently asked questions
How long is the drive from Neuquén to Puerto Madryn?
About 8 h 23 min of driving without stops, over 420 miles.
How far is Puerto Madryn from Neuquén by car?
About 420 miles (676 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the Neuquén to Puerto Madryn drive?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions. Read the full advisory before you go.
Which highways go from Neuquén to Puerto Madryn?
In order: RN22, RN250, RP2 and RN3. The road-by-road table above shows the route miles for each one.
What are good stops between Neuquén and Puerto Madryn?
Closest to the road: Estación Cultural Lucinda Larrosa Museum (museum, mile 8, 2 mi from the route); Museo Patagónico de Ciencias Naturales Juan Carlos Salgado (museum, mile 28, 1 mi from the route); Área natural protegida Bahía de San Antonio (park, mile 258, 2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.