The Wayro route from Manizales to Santa Cruz de Mompós is 503 miles (810 km), about 10 h 33 min of driving without stops.
Read the full advisory before you go: Colombia. Advisory issued: Colombia March 31, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Colombia: “Travel only during daylight hours.”
| Distance by road | 503 mi (810 km) |
|---|---|
| Time at the wheel, no stops | 10 h 33 min |
| Departments on the route | Caldas, Tolima, Cundinamarca, Boyacá, Santander, Cesar, Magdalena, Bolívar |
| Fuel estimate (car at 25 mpg) | about 20.1 gal; actual use varies by vehicle and traffic |
| Stops listed below | 4 |
Driving Manizales to Santa Cruz de Mompós: the shape of the trip
It runs through 8 departments: Caldas, Tolima, Cundinamarca, Boyacá, Santander, Cesar, Magdalena, Bolívar. Of the 4 stops listed below, 2 are within a mile of the road.
Manizales to Santa Cruz de Mompós: the road sequence
| Road | Route miles (from–to) | Length, mi | Department |
|---|---|---|---|
| local roads | 0–503 | 503 | Caldas, Tolima, Cundinamarca, Boyacá, Santander, Cesar, Magdalena, Bolívar |
- Mile 24 of this route: Caldas → Tolima (department line)
- Mile 114 of this route: Tolima → Cundinamarca (department line)
- Mile 122 of this route: Cundinamarca → Caldas (department line)
- Mile 130 of this route: Caldas → Cundinamarca (department line)
- Mile 159 of this route: Cundinamarca → Boyacá (department line)
- Mile 201 of this route: Boyacá → Santander (department line)
- Mile 337 of this route: Santander → Cesar (department line)
- Mile 450 of this route: Cesar → Magdalena (department line)
- Mile 466 of this route: Magdalena → Bolívar (department line)
- Mile 470 of this route: Bolívar → Magdalena (department line)
- Mile 486 of this route: Magdalena → Bolívar (department line)
What to see on the way from Manizales to Santa Cruz de Mompós
- Right off the route (under 1 mile): Catedral de Líbano, Tolima (mile 64), Cathedral of Our Lady of Candelaria, El Banco (mile 460)
- Nature and outdoors: Los Nevados National Natural Park (mile 25)
- Museums and history: Catedral de Líbano, Tolima (mile 64), Our Lady of Mount Carmel Cathedral, La Dorada (mile 137), Cathedral of Our Lady of Candelaria, El Banco (mile 460)
Los Nevados National Natural Park
In the Cordillera Central of the Colombian Andes, Los Nevados National Natural Park takes in the volcanoes Nevado del Ruiz, Nevado del Tolima and Nevado de Santa Isabel.
Catedral de Líbano, Tolima
Dedicated to Our Lady of Carmel, the Catedral de Nuestra Señora del Carmen is a Catholic church in the city of Líbano, in Colombia's Tolima department.
Our Lady of Mount Carmel Cathedral, La Dorada
Facing Simón Bolívar Park in La Dorada, Caldas, Our Lady of Mount Carmel Cathedral is the main church of the Diocese of La Dorada-Guaduas and dates to the mid-20th century.
Cathedral of Our Lady of Candelaria, El Banco
Dedicated to the Virgin of Candelaria, the Cathedral of Our Lady of Candelaria (Catedral de Nuestra Señora de la Candelaria) sits in the south of El Banco, near the town's river dock.
More drives to Santa Cruz de Mompós
- Cúcuta to Santa Cruz de Mompós
- Tunja to Santa Cruz de Mompós
- Sogamoso to Santa Cruz de Mompós
- Armenia to Santa Cruz de Mompós
- Pereira to Santa Cruz de Mompós
- Quibdó to Santa Cruz de Mompós
From Manizales to other places in Colombia
- Manizales to Guatapé
- Manizales to Girardot City
- Manizales to Tuluá
- Manizales to Zipaquirá
- Manizales to Tunja
- Manizales to Sogamoso
Frequently asked questions
How long does it take to drive from Manizales to Santa Cruz de Mompós?
About 10 h 33 min of driving without stops, over 503 miles.
What is the driving distance from Manizales to Santa Cruz de Mompós?
About 503 miles (810 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from Manizales to Santa Cruz de Mompós?
The U.S. State Department rates Colombia Level 3: Reconsider Travel. Read the full advisory before you go.
Where can you stop on the way from Manizales to Santa Cruz de Mompós?
Closest to the road: Catedral de Líbano, Tolima (cathedral, mile 64, 0.1 mi from the route); Our Lady of Mount Carmel Cathedral, La Dorada (cathedral, mile 137, 2 mi from the route); Cathedral of Our Lady of Candelaria, El Banco (cathedral, mile 460, 0.6 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.