The Wayro route from Guanajuato to San Andrés Tuxtla is 533 miles (858 km), about 9 h 10 min of driving without stops.
| Distance | 533 mi (858 km) |
|---|---|
| Driving time, no stops | 9 h 10 min |
| Main roads, in order | MEX-110 → MEX-45 → MEX-45D → MEX-47D → MEX-57D → MEX-M40D → MEX-150D → MEX-179 |
| Mexican states on the route | Guanajuato (Level 3), Querétaro (Level 2), State of Mexico (Level 2), Hidalgo (Level 2), Tlaxcala (Level 2), Puebla (Level 2), Veracruz (Level 2) |
| Toll roads | MEX-45D, MEX-43D, MEX-47D, MEX-57D, MEX-M40D, MEX-150D |
| Fuel estimate (car at 25 mpg) | about 21.3 gal; actual use varies by vehicle and traffic |
| Stops listed below | 8 |
Driving this route in a car with U.S. plates
| Temporary vehicle import permit (TIP) | Required: this route is outside the zones where U.S.-registered cars can skip the temporary import permit (Baja California, Baja California Sur and part of Sonora) |
|---|---|
| Mexican auto insurance | Required for all vehicles: buy a Mexican policy before you drive |
Sources: U.S. State Department, Mexico travel information (updated August 11, 2026); permits are issued by Banjercito.
What the drive from Guanajuato to San Andrés Tuxtla is like
MEX-150D (152 mi) and MEX-M40D (106 mi) carry about 48% of the 533 miles. MEX-45D, MEX-47D, MEX-57D, MEX-M40D, MEX-150D are toll highways (cuota); MEX-110, MEX-45, MEX-179 are free federal roads (libre). It runs through 7 states: Guanajuato, Querétaro, State of Mexico, Hidalgo, Tlaxcala, Puebla, Veracruz. Of the 8 stops listed below, 2 are within a mile of the road.
The route from Guanajuato to San Andrés Tuxtla, road by road
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–1 | 1 | Guanajuato |
| MEX-110 | 1–7 | 6 | Guanajuato |
| local roads | 7–13 | 6 | Guanajuato |
| MEX-45 | 13–23 | 10 | Guanajuato |
| connecting roads | 23–24 | 1 | Guanajuato |
| MEX-45D | 24–75 | 51 | Guanajuato |
| connecting roads | 75–76 | 1 | Guanajuato |
| MEX-47D | 76–128 | 52 | Guanajuato, Querétaro |
| MEX-57D | 128–163 | 35 | Querétaro, State of Mexico |
| connecting roads | 163–164 | 1 | Hidalgo |
| MEX-M40D | 164–270 | 106 | Hidalgo, State of Mexico, Tlaxcala, Puebla |
| connecting roads | 270–271 | 1 | Puebla |
| MEX-150D | 271–423 | 152 | Puebla, Veracruz |
| local roads | 423–497 | 74 | Veracruz |
| MEX-179 | 497–518 | 21 | Veracruz |
| local roads | 518–533 | 15 | Veracruz |
- Mile 88 of this route: Guanajuato → Querétaro (state line)
- Mile 130 of this route: Querétaro → State of Mexico (state line)
- Mile 163 of this route: State of Mexico → Hidalgo (state line)
- Mile 193 of this route: Hidalgo → State of Mexico (state line)
- Mile 207 of this route: State of Mexico → Hidalgo (state line)
- Mile 224 of this route: Hidalgo → State of Mexico (state line)
- Mile 236 of this route: State of Mexico → Hidalgo (state line)
- Mile 244 of this route: Hidalgo → Tlaxcala (state line)
- Mile 267 of this route: Tlaxcala → Puebla (state line)
- Mile 355 of this route: Puebla → Veracruz (state line)
Stops between Guanajuato and San Andrés Tuxtla
- Right off the route (under 1 mile): Tula National Park (mile 176), Cañón del Río Blanco National Park (mile 367)
- Nature and outdoors: Cerro de las Campanas (mile 87), Tula National Park (mile 176), La Malinche National Park (mile 298), Cañón del Río Blanco National Park (mile 367)
- Museums and history: Teotihuacan (mile 224), Casa del Mendrugo (mile 291), Orizaba Cathedral (mile 376), Huatusco (mile 415)
Cerro de las Campanas
Rising within Querétaro City, the Cerro de las Campanas is a hill that is protected as a Mexican national park.
Tula National Park
This park protects the ruins of Tula, ancient capital of the Toltecs. Walk up to the main pyramid to stand beside the Atlantes, basalt warrior figures more than four meters tall, and look for the Coatepantli wall's reliefs of snakes devouring skeletons.
Teotihuacan
Built between the 1st and 7th centuries AD, this UNESCO-listed ancient city lines the Avenue of the Dead, where you can walk between the Pyramid of the Sun, the Pyramid of the Moon and the Temple of the Feathered Serpent.
Casa del Mendrugo
Dating back to the early years of Puebla, founded in 1531, the Casa del Mendrugo is a historic house at 4 Sur 304 in the city's historic center.
La Malinche National Park
Tlaxcala's La Malinche National Park surrounds the inactive Matlalcuéyetl volcano, with pine, oak and fir forests on its slopes, hiking trails, birdwatching, and stone cabins and campsites at the Malintzi Vacation Center.
Cañón del Río Blanco National Park
Cañón del Río Blanco National Park is a protected natural area in the Mexican state of Veracruz, set aside by the government as a national park.
Orizaba Cathedral
The Cathedral of St. Michael the Archangel is the main Catholic church of Orizaba, in the state of Veracruz, and the seat of the Diocese of Orizaba.
Huatusco
Above the Atoyac River in Carrillo Puerto, the ruins of Huatusco (Cuauhtochco) include a Mexica-era temple that still keeps original surface finishes. There are no visitor facilities; reaching it means crossing a suspension bridge and climbing a steep trail, ideally with a local guide.
When you get to San Andrés Tuxtla
Eyipantla Falls
In the Los Tuxtlas region of southern Veracruz, Eyipantla Falls is about 50 meters tall and 40 meters wide and is the main waterfall of the region.
More drives to San Andrés Tuxtla
- Puebla to San Andrés Tuxtla
- Cholula to San Andrés Tuxtla
- Mexico City to San Andrés Tuxtla
- Pachuca to San Andrés Tuxtla
- Cuernavaca to San Andrés Tuxtla
- Toluca to San Andrés Tuxtla
From Guanajuato to other places in Mexico
- Guanajuato to Amatitán
- Guanajuato to Tequila
- Guanajuato to Jerez, Zacatecas
- Guanajuato to Sombrerete
- Guanajuato to El Rosario, Sinaloa
- Guanajuato to San Ignacio, Sinaloa
Continue Your Adventure
Frequently asked questions
How long is the drive from Guanajuato to San Andrés Tuxtla?
About 9 h 10 min of driving without stops, over 533 miles.
How far is San Andrés Tuxtla from Guanajuato by car?
About 533 miles (858 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Do I need a permit to drive my U.S. car from Guanajuato to San Andrés Tuxtla?
Yes. A temporary vehicle import permit (TIP) is required for a U.S.-registered car on this route, which is outside the zones where it can be skipped. Mexican auto insurance is required for every vehicle.
Is it safe to drive from Guanajuato to San Andrés Tuxtla?
The U.S. State Department rates Guanajuato Level 3: Reconsider Travel; Querétaro Level 2: Exercise Increased Caution; State of Mexico Level 2: Exercise Increased Caution; Hidalgo Level 2: Exercise Increased Caution; Tlaxcala Level 2: Exercise Increased Caution; Puebla Level 2: Exercise Increased Caution; Veracruz Level 2: Exercise Increased Caution (advisory issued May 29, 2026). Read the full advisory before you go.
What roads does the drive from Guanajuato to San Andrés Tuxtla use?
In order: MEX-110, MEX-45, MEX-45D, MEX-47D, MEX-57D, MEX-M40D, MEX-150D and MEX-179. The road-by-road table above shows the route miles and states for each one.
What are good stops between Guanajuato and San Andrés Tuxtla?
Closest to the road: Tula National Park (National Park of Mexico, mile 176, 1 mi from the route); Cañón del Río Blanco National Park (National Park of Mexico, mile 367, 0.4 mi from the route); Orizaba Cathedral (cathedral, mile 376, 1 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway mile markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route (roughly 2 to 7 miles depending on the type, farther for World Heritage sites): at least one strong stop for each stretch of the drive, then the best-known places nearest the road, with no more than five of one type, up to nine in all. Places that are closed, private or not open to visitors are removed. Place and city descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on September 29, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.