The Wayro route from Guadalupe, Zacatecas to Calpulalpan is 400 miles (643 km), about 6 h 40 min of driving without stops.
| Distance | 400 mi (643 km) |
|---|---|
| Driving time, no stops | 6 h 40 min |
| Main roads, in order | MEX-45D → MEX-45 → MEX-47D → MEX-57D → MEX-M40D |
| Mexican states on the route | Zacatecas (Level 4), Aguascalientes (Level 2), Jalisco (Level 3), Guanajuato (Level 3), Querétaro (Level 2), State of Mexico (Level 2), Hidalgo (Level 2), Tlaxcala (Level 2) |
| Toll roads | MEX-45D, MEX-43D, MEX-47D, MEX-57D, MEX-M40D |
| Fuel estimate (car at 25 mpg) | about 16.0 gal; actual use varies by vehicle and traffic |
| Stops listed below | 8 |
Driving this route in a car with U.S. plates
| Temporary vehicle import permit (TIP) | Required: this route is outside the zones where U.S.-registered cars can skip the temporary import permit (Baja California, Baja California Sur and part of Sonora) |
|---|---|
| Mexican auto insurance | Required for all vehicles: buy a Mexican policy before you drive |
Sources: U.S. State Department, Mexico travel information (updated August 11, 2026); permits are issued by Banjercito.
What the drive from Guadalupe, Zacatecas to Calpulalpan is like
MEX-45D (163 mi) and MEX-M40D (78 mi) carry about 60% of the 400 miles. MEX-45D, MEX-47D, MEX-57D, MEX-M40D are toll highways (cuota); MEX-45 is a free federal road (libre). It runs through 8 states: Zacatecas, Aguascalientes, Jalisco, Guanajuato, Querétaro, State of Mexico, Hidalgo, Tlaxcala. Of the 8 stops listed below, 1 are within a mile of the road.
The route from Guadalupe, Zacatecas to Calpulalpan, road by road
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–4 | 4 | Zacatecas |
| MEX-45D | 4–25 | 21 | Zacatecas |
| MEX-45 | 25–53 | 28 | Zacatecas, Aguascalientes |
| local roads | 53–57 | 4 | Aguascalientes |
| MEX-45 | 57–87 | 30 | Aguascalientes, Jalisco |
| MEX-45D | 87–229 | 142 | Jalisco, Guanajuato |
| MEX-47D | 229–281 | 52 | Guanajuato, Querétaro |
| MEX-57D | 281–316 | 35 | Querétaro, State of Mexico |
| connecting roads | 316–318 | 2 | Hidalgo |
| MEX-M40D | 318–396 | 78 | Hidalgo, State of Mexico |
| local roads | 396–400 | 4 | Tlaxcala |
- Mile 30 of this route: Zacatecas → Aguascalientes (state line)
- Mile 83 of this route: Aguascalientes → Jalisco (state line)
- Mile 132 of this route: Jalisco → Guanajuato (state line)
- Mile 242 of this route: Guanajuato → Querétaro (state line)
- Mile 283 of this route: Querétaro → State of Mexico (state line)
- Mile 316 of this route: State of Mexico → Hidalgo (state line)
- Mile 345 of this route: Hidalgo → State of Mexico (state line)
- Mile 360 of this route: State of Mexico → Hidalgo (state line)
- Mile 377 of this route: Hidalgo → State of Mexico (state line)
- Mile 389 of this route: State of Mexico → Hidalgo (state line)
- Mile 396 of this route: Hidalgo → Tlaxcala (state line)
Stops between Guadalupe, Zacatecas and Calpulalpan
- Right off the route (under 1 mile): Aguascalientes Museum (mile 68)
- Nature and outdoors: Cerro de las Campanas (mile 240)
- Museums and history: Aguascalientes Museum (mile 68), Celaya Cathedral (mile 217), Sala Histórica Quetzalcóatl (mile 328), Teotihuacan (mile 377)
Aguascalientes Museum
Located in the state capital, the Aguascalientes Museum is the city's art museum, set in the city of Aguascalientes, Mexico.
Celaya Cathedral
Celaya's main Catholic church, the Immaculate Conception Cathedral, occupies the space of a former chapel that was annexed to the neighboring Temple of St. Francis.
Cerro de las Campanas
Rising within Querétaro City, the Cerro de las Campanas is a hill that is protected as a Mexican national park.
Sala Histórica Quetzalcóatl
The Sala Histórica Quetzalcóatl is an archaeological museum located in Tula de Allende, in the Mexican state of Hidalgo.
Atlantean figures
Crowning the main pyramid at the Tula archaeological zone, these basalt sculptures of Toltec warriors stand more than four meters tall in what was once the Toltec capital; the nearby Wall of Snakes shows carved serpents devouring skeletons.
Church and former convent of Todos los Santos
Franciscan friars built this fortress-style convent in Zempoala, and the complex still keeps the classic layout of atrium, church, open chapel and cloister. It pairs well with a drive through the area's old pulque haciendas.
Teotihuacan
Built between the 1st and 7th centuries AD, this UNESCO-listed ancient city lines the Avenue of the Dead, where you can walk between the Pyramid of the Sun, the Pyramid of the Moon and the Temple of the Feathered Serpent.
Aqueduct of Padre Tembleque
Built by Franciscan friar Francisco de Tembleque between 1554 and 1572, this 16th-century water system runs more than 48 km between Zempoala and Otumba. Its tallest arcade at Tepeyahualco reaches almost 40 meters, and UNESCO listed it in 2015.
When you get to Calpulalpan
Tecoaque
Near Calpulalpan in western Tlaxcala, Tecoaque is a Mesoamerican archaeological site once inhabited by the Acolhua, one of the three groups that made up the Aztec Empire.
More drives to Calpulalpan
- Mexico City to Calpulalpan
- Pachuca to Calpulalpan
- Tepotzotlán to Calpulalpan
- Toluca to Calpulalpan
- Cuautla to Calpulalpan
- Cuernavaca to Calpulalpan
From Guadalupe, Zacatecas to other places in Mexico
- Guadalupe, Zacatecas to San Juan de los Lagos
- Guadalupe, Zacatecas to Temacapulín
- Guadalupe, Zacatecas to Tepatitlán
- Guadalupe, Zacatecas to Amatitán
- Guadalupe, Zacatecas to Ajijic
- Guadalupe, Zacatecas to Tequila
Continue Your Adventure
Frequently asked questions
How long is the drive from Guadalupe, Zacatecas to Calpulalpan?
About 6 h 40 min of driving without stops, over 400 miles.
How far is Calpulalpan from Guadalupe, Zacatecas by car?
About 400 miles (643 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Do I need a permit to drive my U.S. car from Guadalupe, Zacatecas to Calpulalpan?
Yes. A temporary vehicle import permit (TIP) is required for a U.S.-registered car on this route, which is outside the zones where it can be skipped. Mexican auto insurance is required for every vehicle.
Is it safe to drive from Guadalupe, Zacatecas to Calpulalpan?
The U.S. State Department rates Zacatecas Level 4: Do Not Travel; Aguascalientes Level 2: Exercise Increased Caution; Jalisco Level 3: Reconsider Travel; Guanajuato Level 3: Reconsider Travel; Querétaro Level 2: Exercise Increased Caution; State of Mexico Level 2: Exercise Increased Caution; Hidalgo Level 2: Exercise Increased Caution; Tlaxcala Level 2: Exercise Increased Caution (advisory issued May 29, 2026). Read the full advisory before you go.
What roads does the drive from Guadalupe, Zacatecas to Calpulalpan use?
In order: MEX-45D, MEX-45, MEX-47D, MEX-57D and MEX-M40D. The road-by-road table above shows the route miles and states for each one.
What are good stops between Guadalupe, Zacatecas and Calpulalpan?
Closest to the road: Aguascalientes Museum (art museum, mile 68, 0.4 mi from the route); Sala Histórica Quetzalcóatl (museum, mile 328, 1 mi from the route); Atlantean figures (atlantean figures, mile 329, 1 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway mile markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route (roughly 2 to 7 miles depending on the type, farther for World Heritage sites): at least one strong stop for each stretch of the drive, then the best-known places nearest the road, with no more than five of one type, up to nine in all. Places that are closed, private or not open to visitors are removed. Place and city descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on September 29, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.