Plan on about 6 h 8 min of driving for the 286-mile (460 km) trip from Colonia del Sacramento to Treinta y Tres, before any stops.
Full advisory: Uruguay. Advisory issued: Uruguay July 28, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Uruguay: “Several of the main highways are particularly accident-ridden.”
| Total distance | 286 mi (460 km) |
|---|---|
| Drive time without stops | 6 h 8 min |
| Departments on the route | Colonia, San José, Canelones, Lavalleja, Treinta y Tres |
| Fuel estimate (car at 25 mpg) | about 11.4 gal; actual use varies by vehicle and traffic |
| Stops listed below | 8 |
The Colonia del Sacramento–Treinta y Tres drive in a few lines
It runs through 5 departments: Colonia, San José, Canelones, Lavalleja, Treinta y Tres. Of the 8 stops listed below, 4 are within a mile of the road.
Roads you'll take from Colonia del Sacramento to Treinta y Tres
| Road | Route miles (from–to) | Length, mi | Department |
|---|---|---|---|
| local roads | 0–46 | 46 | Colonia, San José |
| connecting roads | 46–47 | 1 | San José |
| local roads | 47–68 | 21 | San José |
| connecting roads | 68–71 | 3 | San José |
| local roads | 71–138 | 67 | San José, Canelones |
| connecting roads | 138–139 | 1 | Canelones |
| local roads | 139–286 | 147 | Canelones, Lavalleja, Treinta y Tres |
- Mile 45 of this route: Colonia → San José (department line)
- Mile 93 of this route: San José → Canelones (department line)
- Mile 158 of this route: Canelones → Lavalleja (department line)
- Mile 268 of this route: Lavalleja → Treinta y Tres (department line)
Where to stop on the way to Treinta y Tres
- Right off the route (under 1 mile): Cathedral of San José de Mayo (mile 68), Museo Departamental de San José (mile 68), Cathedral of Our Lady of Guadalupe (mile 103), Cathedral of Minas (mile 183)
- Nature and outdoors: Parque nacional Arequita (mile 183), Salto del Penitente (mile 193)
- Museums and history: Museum of Rosario Mural Art (mile 30), Cathedral of San José de Mayo (mile 68), Museo Departamental de San José (mile 68), Cathedral of Our Lady of Guadalupe (mile 103), Iglesia de Cristo Obrero y Nuestra Señora de Lourdes (mile 139), Cathedral of Minas (mile 183)
Museum of Rosario Mural Art
Rather than a building, the Museum of Rosario Mural Art is a circuit of history-themed murals spread around Rosario, in Uruguay's Colonia department.
Cathedral of San José de Mayo
The main Catholic church of San José de Mayo, the Cathedral Basilica of St. Joseph has been the diocesan seat since 1955, a minor basilica since 1957 and Uruguay's national shrine of Saint Joseph.
Museo Departamental de San José
Set in central San José de Mayo, the Museo Departamental de San José is a history and fine arts museum that also runs a library, archives and cultural programs.
Cathedral of Our Lady of Guadalupe
Construction of Canelones' Cathedral of Our Lady of Guadalupe began in 1816; the church became a cathedral in 1961 and Uruguay's national shrine of Our Lady of Guadalupe in 2020.
Iglesia de Cristo Obrero y Nuestra Señora de Lourdes
Since 2021, UNESCO has counted Eladio Dieste's Church of Christ the Worker among its World Heritage Sites. The engineer's brick church in Estación Atlántida was inaugurated in 1960 and is known for its undulating walls and roof.
Cathedral of Minas
Minas's main Catholic church, the Cathedral of the Immaculate Conception served as the seat of the Diocese of Minas from 1960 to 2020.
Parque nacional Arequita
Arequita National Park is a protected natural area in Lavalleja department, southeastern Uruguay, known for Cerro Arequita, its related rock formations and its biodiversity.
Salto del Penitente
Once you reach Treinta y Tres
Museo Agustín Araújo
Treinta y Tres's departmental fine arts museum, the Museo Agustín Araújo is a public museum in the city of Treinta y Tres, Uruguay.
More drives to Treinta y Tres
- Montevideo to Treinta y Tres
- Rivera to Treinta y Tres
- Salto to Treinta y Tres
- Fray Bentos to Treinta y Tres
- Buenos Aires to Treinta y Tres, Uruguay
- Rosario, Argentina to Treinta y Tres, Uruguay
From Colonia del Sacramento to other places in Uruguay
- Colonia del Sacramento to Veinticinco de Agosto
- Colonia del Sacramento to Fray Marcos
- Colonia del Sacramento to Alejandro Gallinal
- Colonia del Sacramento to Barra de Valizas
- Colonia del Sacramento to Punta del Diablo
- Colonia del Sacramento to Chuy
Continue Your Adventure
Frequently asked questions
How long is the drive from Colonia del Sacramento to Treinta y Tres?
About 6 h 8 min of driving without stops, over 286 miles.
What is the driving distance from Colonia del Sacramento to Treinta y Tres?
About 286 miles (460 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the Colonia del Sacramento to Treinta y Tres drive?
The U.S. State Department rates Uruguay Level 2: Exercise Increased Caution. Read the full advisory before you go.
Where can you stop on the way from Colonia del Sacramento to Treinta y Tres?
Closest to the road: Museo Departamental de San José (history museum, mile 68, 0.7 mi from the route); Cathedral of Our Lady of Guadalupe (cathedral, mile 103, 0.0 mi from the route); Cathedral of Minas (cathedral, mile 183, 0.6 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.