The Wayro route from Tlaxcala to Comalcalco is 401 miles (646 km), about 7 h 13 min of driving without stops.
| Distance by road | 401 mi (646 km) |
|---|---|
| Driving time, no stops | 7 h 13 min |
| Main roads, in order | MEX-119 → MEX-150D → MEX-145D → MEX-180D → MEX-180 → MEX-187 |
| Mexican states on the route | Tlaxcala, Puebla, Veracruz, Tabasco |
| Toll roads (as marked in OpenStreetMap) | MEX-150D, MEX-145D, MEX-180D |
| Fuel estimate (car at 25 mpg) | about 16.1 gal; actual use varies by vehicle and traffic |
| Stops listed below | 7 |
Driving this route in a car with U.S. plates
| Temporary vehicle import permit (TIP) | Required: this route is outside the zones where U.S.-registered cars can skip the temporary import permit (Baja California, Baja California Sur and part of Sonora) |
|---|---|
| Mexican auto insurance | Required for all vehicles: buy a Mexican policy before you drive |
Sources: U.S. State Department, Mexico travel information (updated August 11, 2026); permits are issued by Banjercito.
Driving Tlaxcala to Comalcalco: the shape of the trip
MEX-150D (131 mi) and MEX-180D (53 mi) carry about 46% of the 401 miles. It runs through 4 states: Tlaxcala, Puebla, Veracruz, Tabasco. OpenStreetMap marks tolled sections on MEX-150D, MEX-145D and MEX-180D. Of the 7 stops listed below, 1 are within a mile of the road.
Tlaxcala to Comalcalco: the road sequence
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–2 | 2 | Tlaxcala |
| MEX-119 | 2–17 | 15 | Tlaxcala, Puebla |
| connecting roads | 17–19 | 2 | Puebla |
| MEX-150D | 19–150 | 131 | Puebla, Veracruz |
| local roads | 150–261 | 111 | Veracruz |
| MEX-145D | 261–293 | 32 | Veracruz |
| MEX-180D | 293–313 | 20 | Veracruz |
| MEX-180 | 313–332 | 19 | Veracruz, Tabasco |
| MEX-180D | 332–365 | 33 | Tabasco |
| MEX-180 | 365–377 | 12 | Tabasco |
| MEX-187 | 377–398 | 21 | Tabasco |
| local roads | 398–401 | 3 | Tabasco |
- Mile 16 of this route: Tlaxcala → Puebla (state line)
- Mile 83 of this route: Puebla → Veracruz (state line)
- Mile 331 of this route: Veracruz → Tabasco (state line)
Stops between Tlaxcala and Comalcalco
- Right off the route (under 1 mile): Cañón del Río Blanco National Park (mile 95)
- Nature and outdoors: Parque ecológico Los Ladrillos (mile 10), La Malinche National Park (mile 27), Cañón del Río Blanco National Park (mile 95)
- Museums and history: Casa del Alfeñique (mile 19), Orizaba Cathedral (mile 104), Huatusco (mile 144), La Venta (mile 333)
Parque ecológico Los Ladrillos
Opened on April 2, 2015, Los Ladrillos Ecological Park is a nature reserve in the municipality of Zacatelco, in Tlaxcala.
Casa del Alfeñique
Founded in 1926, the Museo Regional Casa de Alfeñique is a museum in the city of Puebla, housed in the building known as the Casa de Alfeñique.
La Malinche National Park
Pine, oak and fir forests cover the slopes of the inactive Matlalcuéyetl volcano, the centerpiece of La Malinche National Park in Tlaxcala.
Cañón del Río Blanco National Park
Veracruz is home to Cañón del Río Blanco National Park, a natural area that the Mexican government has set aside for protection.
Orizaba Cathedral
The Cathedral of St. Michael the Archangel is the main Catholic church of Orizaba, in the state of Veracruz, and the seat of the Diocese of Orizaba.
Huatusco
Above the Atoyac River in Carrillo Puerto, Cuauhtochco has a Mexica-era temple that still keeps original surface finishes. Expect no visitor facilities, and consider hiring a local guide.
La Venta
La Venta was an important city of the Olmec civilization, in Tabasco near Huimanguillo. Its site museum displays more than 200 artifacts, including monumental sandstone sculptures found at the foot of the main pyramid.
Arriving in Comalcalco
Comalcalco
Next to the modern city of the same name in Tabasco, Comalcalco is an ancient Maya site that stands out as a major Maya city built with bricks instead of limestone, and the westernmost of the civilization.
More drives to Comalcalco
- Chiautempan to Comalcalco
- Cuautla to Comalcalco
- Pachuca to Comalcalco
- Tulancingo to Comalcalco
- Cuernavaca to Comalcalco
- Tepotzotlán to Comalcalco
From Tlaxcala to other places in Mexico
- Tlaxcala to Omitlán
- Tlaxcala to Atlatlahucan
- Tlaxcala to Huasca de Ocampo
- Tlaxcala to Actopan
- Tlaxcala to Metepec
- Tlaxcala to Malinalco
Continue Your Adventure
Frequently asked questions
How long is the drive from Tlaxcala to Comalcalco?
About 7 h 13 min of driving without stops, over 401 miles.
How far is Comalcalco from Tlaxcala by car?
About 401 miles (646 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Do I need a permit to drive my U.S. car from Tlaxcala to Comalcalco?
Yes. A temporary vehicle import permit (TIP) is required for a U.S.-registered car on this route, which is outside the zones where it can be skipped. Mexican auto insurance is required for every vehicle.
Is it safe to drive from Tlaxcala to Comalcalco?
The U.S. State Department rates Tlaxcala Level 2: Exercise Increased Caution; Puebla Level 2: Exercise Increased Caution; Veracruz Level 2: Exercise Increased Caution; Tabasco Level 2: Exercise Increased Caution (advisory issued May 29, 2026). Read the full advisory before you go.
Which highways go from Tlaxcala to Comalcalco?
In order: MEX-119, MEX-150D, MEX-145D, MEX-180D, MEX-180 and MEX-187. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from Tlaxcala to Comalcalco?
Closest to the road: Parque ecológico Los Ladrillos (park, mile 10, 1 mi from the route); Cañón del Río Blanco National Park (national park, mile 95, 0.4 mi from the route); Orizaba Cathedral (cathedral, mile 104, 1 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on September 29, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.