The Wayro route from São Vicente to Assis is 308 miles (496 km), about 5 h 44 min of driving without stops.
- Level 4: Do Not Travel in Brazil: informal housing developments (favelas, vilas, comunidades or conglomerados).
Full advisory: Brazil. Advisory issued: Brazil August 31, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Brazil: “Road maintenance is inadequate in many areas.”
| Distance | 308 mi (496 km) |
|---|---|
| Drive time without stops | 5 h 44 min |
| Main roads, in order | SP-160 → SP-015 → SP-280 → SP-225 → SP-327 → SP-270 |
| States on the route | São Paulo |
| Fuel estimate (car at 25 mpg) | about 12.3 gal; actual use varies by vehicle and traffic |
| Stops listed below | 9 |
How the São Vicente to Assis drive plays out
SP-280 (189 mi) and SP-270 (37 mi) carry about 73% of the 308 miles. Of the 9 stops listed below, 1 are within a mile of the road.
The route from São Vicente to Assis, road by road
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–1 | 1 | São Paulo |
| SP-160 | 1–37 | 36 | São Paulo |
| local roads | 37–42 | 5 | São Paulo |
| SP-015 | 42–48 | 6 | São Paulo |
| SP-280 | 48–237 | 189 | São Paulo |
| SP-225 | 237–249 | 12 | São Paulo |
| SP-327 | 249–269 | 20 | São Paulo |
| SP-270 | 269–306 | 37 | São Paulo |
| local roads | 306–308 | 2 | São Paulo |
What to see on the way from São Vicente to Assis
- Right off the route (under 1 mile): Botanical Garden of São Paulo (mile 37)
- Nature and outdoors: Botanical Garden of São Paulo (mile 37), Parque Geológico do Varvito (mile 91)
- Museums and history: Pinacoteca de São Bernardo do Campo (mile 32), Botanical Garden of São Paulo (mile 37), Museu Lasar Segall (mile 39), São Paulo Museum of Modern Art (mile 41), Casa Guilherme de Almeida (mile 45)
- With kids: Cidade da Criança (mile 32), Simba Safari (mile 35)
Cidade da Criança
Opened on October 10, 1968, Cidade da Criança in São Bernardo do Campo was the first theme park in Brazil and Latin America and sits behind the former Vera Cruz Film Studios.
Pinacoteca de São Bernardo do Campo
This municipal art gallery in São Bernardo do Campo studies and shows modern and contemporary art, with works by Tomie Ohtake, Waldomiro de Deus and Wesley Duke Lee in its collection.
Simba Safari
At Simba Safari, a zoo in São Paulo's Cursino district, visitors ride park vehicles along a route of about 2.9 km through roughly 80,000 square meters to see the animals.
Botanical Garden of São Paulo
Next to the São Paulo Zoo, the Botanical Garden of São Paulo spans 406 acres inside Fontes do Ipiranga State Park, in the Água Funda district of the city's South Zone.
Museu Lasar Segall
Housed in the home and studio architect Gregori Warchavchik designed in 1932, the Museu Lasar Segall in São Paulo is an art museum devoted to artist Lasar Segall, who lived there until 1957.
São Paulo Museum of Modern Art
Set inside Ibirapuera Park, the São Paulo Museum of Modern Art was founded by Francisco Matarazzo Sobrinho and Yolanda Penteado in 1948 and modeled on New York's Museum of Modern Art.
Gazeta Theatre
Located at the Cásper Líbero Foundation in São Paulo, Teatro Gazeta opened in 1966 as the Cine Gazeta.
Casa Guilherme de Almeida
Casa Guilherme de Almeida is a biographical and literary museum in São Paulo, founded in 1979 and run as a public museum under the São Paulo State Secretariat of Culture.
Parque Geológico do Varvito
In Itu, a closed quarry exposes layers of varvite, sediment laid down in glacial lakes about 280 million years ago. Parque Geológico do Varvito lets visitors walk past these banded rock walls, a protected geological monument.
Arriving in Assis
Estação de Assis
Assis's railway station joined the company's trunk line in 1914 and got its current building in 1926; the original station was adapted as housing for traffic staff in 1927.
Museu de Arte Primitiva de Assis
Assis's museum of primitive (naïve) art, founded by José Nazareno Mimessi, sits inside Parque do Buracão, an ecological park, in its own climate-controlled building opened in 1999. It is run by the city's culture department.
More drives to Assis
- Jaú to Assis
- Araraquara to Assis
- Ribeirão Preto to Assis
- São Paulo to Assis
- Mogi Guaçu to Assis
- Poços de Caldas to Assis
From São Vicente to other places in Brazil
- São Vicente to Paranapiacaba
- São Vicente to Bragança Paulista
- São Vicente to Itu
- São Vicente to Limeira
- São Vicente to Mogi Guaçu
- São Vicente to Botucatu
Frequently asked questions
How long does it take to drive from São Vicente to Assis?
About 5 h 44 min of driving without stops, over 308 miles.
How far is Assis from São Vicente by car?
About 308 miles (496 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from São Vicente to Assis?
The U.S. State Department rates Brazil Level 2: Exercise Increased Caution. Read the full advisory before you go.
Which highways go from São Vicente to Assis?
In order: SP-160, SP-015, SP-280, SP-225, SP-327 and SP-270. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from São Vicente to Assis?
Closest to the road: Simba Safari (zoo, mile 35, 1 mi from the route); Botanical Garden of São Paulo (museum, mile 37, 0.7 mi from the route); São Paulo Museum of Modern Art (museum of modern art, mile 41, 2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.