The Wayro route from São Paulo to Assis is 269 miles (433 km), about 4 h 55 min of driving without stops.
- Level 4: Do Not Travel in Brazil: informal housing developments (favelas, vilas, comunidades or conglomerados).
Full advisory: Brazil. Advisory issued: Brazil August 31, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Brazil: “Road maintenance is inadequate in many areas.”
| Distance | 269 mi (433 km) |
|---|---|
| Driving time, no stops | 4 h 55 min |
| Main roads, in order | SP-015 → SP-280 → SP-225 → SP-327 → SP-270 |
| States on the route | São Paulo |
| Fuel estimate (car at 25 mpg) | about 10.8 gal; actual use varies by vehicle and traffic |
| Stops listed below | 5 |
On the road from São Paulo to Assis
SP-280 (184 mi) and SP-270 (36 mi) carry about 82% of the 269 miles. Of the 5 stops listed below, 2 are within a mile of the road.
São Paulo to Assis: the road sequence
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–4 | 4 | São Paulo |
| SP-015 | 4–9 | 5 | São Paulo |
| connecting roads | 9–13 | 4 | São Paulo |
| SP-280 | 13–197 | 184 | São Paulo |
| connecting roads | 197–198 | 1 | São Paulo |
| SP-225 | 198–209 | 11 | São Paulo |
| SP-327 | 209–230 | 21 | São Paulo |
| SP-270 | 230–266 | 36 | São Paulo |
| local roads | 266–269 | 3 | São Paulo |
Places worth a stop between São Paulo and Assis
- Right off the route (under 1 mile): Museu do Relógio Professor Dimas de Melo Pimenta (mile 9), Municipal Museum of Barueri (mile 19)
- Nature and outdoors: Parque Geológico do Varvito (mile 52)
- Museums and history: Museu do Relógio Professor Dimas de Melo Pimenta (mile 9), Museu de Anatomia Humana da Universidade de São Paulo (mile 10), Municipal Museum of Barueri (mile 19), Museum of Art of the Parliament of Itapevi (mile 22)
Museu do Relógio Professor Dimas de Melo Pimenta
This themed clock museum in Vila Leopoldina, in São Paulo's West Zone, traces the history and technology of timekeeping through many types of clocks, and links accurate time to weather forecasting.
Museu de Anatomia Humana da Universidade de São Paulo
Founded by Professor Alfonso Bovero, the Museum of Human Anatomy of the University of São Paulo grew out of his teaching of anatomy and histology at the old medical school.
Municipal Museum of Barueri
In the Jardim Belval neighborhood of Barueri, the Oswaldo Abat Municipal Museum occupies a heritage building and holds Indigenous objects excavated at the Aldeia de Barueri, photographs and sculptures on local history.
Museum of Art of the Parliament of Itapevi
Named for Emanuel von Lauenstein Massarani, this contemporary art museum is housed in the Itapevi city council building, in the northeast part of the city.
Parque Geológico do Varvito
Banded rock walls line a former quarry in Itu, where Parque Geológico do Varvito shows off varvite, sediment that settled in glacial lakes some 280 million years ago.
In Assis itself
Estação de Assis
Assis's railway station joined the company's trunk line in 1914 and got its current building in 1926; the original station was adapted as housing for traffic staff in 1927.
Museu de Arte Primitiva de Assis
Assis's museum of primitive (naïve) art, founded by José Nazareno Mimessi, sits inside Parque do Buracão, an ecological park, in its own climate-controlled building opened in 1999. It is run by the city's culture department.
More drives to Assis
- Jaú to Assis
- Araraquara to Assis
- Ribeirão Preto to Assis
- Mogi Guaçu to Assis
- Poços de Caldas to Assis
- Uberaba to Assis
From São Paulo to other places in Brazil
- São Paulo to Jundiaí
- São Paulo to Bragança Paulista
- São Paulo to Campinas
- São Paulo to Itu
- São Paulo to Mogi Guaçu
- São Paulo to São Carlos
Frequently asked questions
How long is the drive from São Paulo to Assis?
About 4 h 55 min of driving without stops, over 269 miles.
What is the driving distance from São Paulo to Assis?
About 269 miles (433 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the São Paulo to Assis drive?
The U.S. State Department rates Brazil Level 2: Exercise Increased Caution. Read the full advisory before you go.
Which highways go from São Paulo to Assis?
In order: SP-015, SP-280, SP-225, SP-327 and SP-270. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from São Paulo to Assis?
Closest to the road: Museu do Relógio Professor Dimas de Melo Pimenta (museum, mile 9, 0.6 mi from the route); Municipal Museum of Barueri (museum, mile 19, 0.5 mi from the route); Museum of Art of the Parliament of Itapevi (museum, mile 22, 2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.