Santos to Três Lagoas is about 457 road miles (736 km): roughly 8 h 60 min at the wheel if you don't stop.
- Level 4: Do Not Travel in Brazil: informal housing developments (favelas, vilas, comunidades or conglomerados).
Full advisory: Brazil. Advisory issued: Brazil August 31, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Brazil: “Drivers must have their daytime running lights on during the day and headlights on at night on Federal Highways.”
| Distance by road | 457 mi (736 km) |
|---|---|
| Drive time without stops | 8 h 60 min |
| Main roads, in order | SP-160 → SP-015 → SP-280 → SP-209 → SP-300 → BR-262 |
| States on the route | São Paulo, Mato Grosso do Sul |
| Fuel estimate (car at 25 mpg) | about 18.3 gal; actual use varies by vehicle and traffic |
| Stops listed below | 9 |
On the road from Santos to Três Lagoas
SP-300 (256 mi) and SP-280 (123 mi) carry about 83% of the 457 miles. It runs through 2 states: São Paulo, Mato Grosso do Sul. Of the 9 stops listed below, 2 are within a mile of the road.
Santos to Três Lagoas: the road sequence
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–6 | 6 | São Paulo |
| SP-160 | 6–41 | 35 | São Paulo |
| local roads | 41–47 | 6 | São Paulo |
| SP-015 | 47–53 | 6 | São Paulo |
| SP-280 | 53–176 | 123 | São Paulo |
| SP-209 | 176–188 | 12 | São Paulo |
| connecting roads | 188–189 | 1 | São Paulo |
| SP-300 | 189–243 | 54 | São Paulo |
| local roads | 243–247 | 4 | São Paulo |
| SP-300 | 247–449 | 202 | São Paulo |
| BR-262 | 449–454 | 5 | São Paulo, Mato Grosso do Sul |
| local roads | 454–457 | 3 | Mato Grosso do Sul |
- Mile 452 of this route: São Paulo → Mato Grosso do Sul (state line)
Places worth a stop between Santos and Três Lagoas
- Right off the route (under 1 mile): Botanical Garden of São Paulo (mile 41), Thermas Acqualinda (mile 431)
- Nature and outdoors: Botanical Garden of São Paulo (mile 41)
- Museums and history: Botanical Garden of São Paulo (mile 41), Centro de Memória do Corpo de Bombeiros (mile 43), Fundação Maria Luisa e Oscar Americano (mile 47), Monument to the Bandeiras (mile 47), Museu de Anatomia Humana da Universidade de São Paulo (mile 51), Museu Histórico Municipal de Bauru (mile 247), Headquarters of Fazenda Divisa (mile 254)
- With kids: Simba Safari (mile 40), Thermas Acqualinda (mile 431)
Simba Safari
At Simba Safari, a zoo in São Paulo's Cursino district, visitors ride park vehicles along a route of about 2.9 km through roughly 80,000 square meters to see the animals.
Botanical Garden of São Paulo
Next to the São Paulo Zoo, the Botanical Garden of São Paulo spans 406 acres inside Fontes do Ipiranga State Park, in the Água Funda district of the city's South Zone.
Centro de Memória do Corpo de Bombeiros
São Paulo's Centro de Memória do Corpo de Bombeiros is a fire department museum opened on May 10, 2005, marking 125 years since the corps was founded.
Fundação Maria Luisa e Oscar Americano
Once the home of Maria Luisa and Oscar Americano, this São Paulo museum foundation occupies the property the couple donated to the city as a place for leisure and culture.
Monument to the Bandeiras
Victor Brecheret's large granite sculpture, the Monument to the Bandeiras, stands at the entrance of Ibirapuera Park; it was commissioned in 1921 and completed in 1954.
Museu de Anatomia Humana da Universidade de São Paulo
Founded by Professor Alfonso Bovero, the Museum of Human Anatomy of the University of São Paulo grew out of his teaching of anatomy and histology at the old medical school.
Museu Histórico Municipal de Bauru
Photos, newspapers, documents, furniture, machines and tools tied to the city's past fill the Museu Histórico Municipal de Bauru, which tells the history of Bauru.
Headquarters of Fazenda Divisa
The Headquarters of Fazenda Divisa (Casa-Sede da Fazenda Divisa) is a historic building in Bauru, protected by the city's cultural heritage council since 2005.
Thermas Acqualinda
Thermas Acqualinda is a themed thermal water park in Andradina, São Paulo state, built by politician and businessman Mário Celso Lopes as a leisure complex.
When you get to Três Lagoas
Lagoa Maior
Lagoa Maior is the main of the three urban lagoons that give Três Lagoas, in Mato Grosso do Sul, its name; it spans about 418,000 square meters and is under three meters deep.
More drives to Três Lagoas
- Botucatu to Três Lagoas
- Ribeirão Preto to Três Lagoas
- Campinas to Três Lagoas
- Poços de Caldas to Três Lagoas
- Cascavel to Três Lagoas
- São Paulo to Três Lagoas
From Santos to other places in Brazil
- Santos to Itanhaém
- Santos to Bragança Paulista
- Santos to Itu
- Santos to Limeira
- Santos to Mogi Guaçu
- Santos to Botucatu
Frequently asked questions
How long does it take to drive from Santos to Três Lagoas?
About 8 h 60 min of driving without stops, over 457 miles.
How far is Três Lagoas from Santos by car?
About 457 miles (736 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from Santos to Três Lagoas?
The U.S. State Department rates Brazil Level 2: Exercise Increased Caution. Read the full advisory before you go.
Which highways go from Santos to Três Lagoas?
In order: SP-160, SP-015, SP-280, SP-209, SP-300 and BR-262. The road-by-road table above shows the route miles for each one.
What are good stops between Santos and Três Lagoas?
Closest to the road: Botanical Garden of São Paulo (museum, mile 41, 0.7 mi from the route); Headquarters of Fazenda Divisa (historic estate, mile 254, 1 mi from the route); Thermas Acqualinda (water park, mile 431, 0.2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.