The Wayro route from São Paulo to Três Lagoas is 414 miles (666 km), about 8 h 1 min of driving without stops.
- Level 4: Do Not Travel in Brazil: informal housing developments (favelas, vilas, comunidades or conglomerados).
Full advisory: Brazil. Advisory issued: Brazil August 31, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Brazil: “Driving on Brazil’s roads poses significant risks.”
| Distance by road | 414 mi (666 km) |
|---|---|
| Driving time, no stops | 8 h 1 min |
| Main roads, in order | SP-015 → SP-280 → SP-209 → SP-300 → BR-262 |
| States on the route | São Paulo, Mato Grosso do Sul |
| Fuel estimate (car at 25 mpg) | about 16.5 gal; actual use varies by vehicle and traffic |
| Stops listed below | 7 |
How the São Paulo to Três Lagoas drive plays out
SP-300 (255 mi) and SP-280 (119 mi) carry about 90% of the 414 miles. It runs through 2 states: São Paulo, Mato Grosso do Sul. Of the 7 stops listed below, 2 are within a mile of the road.
The route from São Paulo to Três Lagoas, road by road
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–4 | 4 | São Paulo |
| SP-015 | 4–9 | 5 | São Paulo |
| connecting roads | 9–13 | 4 | São Paulo |
| SP-280 | 13–132 | 119 | São Paulo |
| SP-209 | 132–144 | 12 | São Paulo |
| connecting roads | 144–145 | 1 | São Paulo |
| SP-300 | 145–199 | 54 | São Paulo |
| local roads | 199–204 | 5 | São Paulo |
| SP-300 | 204–405 | 201 | São Paulo |
| BR-262 | 405–409 | 4 | São Paulo, Mato Grosso do Sul |
| local roads | 409–414 | 5 | Mato Grosso do Sul |
- Mile 408 of this route: São Paulo → Mato Grosso do Sul (state line)
Breaking up the drive: stops between São Paulo and Três Lagoas
- Right off the route (under 1 mile): Dimitri Sensaud de Lavaud Museum (mile 12), Thermas Acqualinda (mile 388)
- Nature and outdoors: Parque Geológico do Varvito (mile 52)
- Museums and history: Centro Cultural e de Estudos Superiores Aúthos Pagano (mile 7), Museu de Anatomia Humana da Universidade de São Paulo (mile 10), Dimitri Sensaud de Lavaud Museum (mile 12), Pinacoteca Municipal de Bauru (mile 203), Headquarters of Fazenda Divisa (mile 210)
- With kids: Thermas Acqualinda (mile 388)
Centro Cultural e de Estudos Superiores Aúthos Pagano
In São Paulo's Alto da Lapa neighborhood, this cultural center is a state public institution maintained by the São Paulo State Secretariat of Culture and Creative Economy together with a civil society organization.
Museu de Anatomia Humana da Universidade de São Paulo
Founded by Professor Alfonso Bovero, the Museum of Human Anatomy of the University of São Paulo grew out of his teaching of anatomy and histology at the old medical school.
Dimitri Sensaud de Lavaud Museum
Also called the Osasco Museum, the Dimitri Sensaud de Lavaud Museum occupies a 19th-century mansion built by Antônio Agú for banker Giovanni Brícola in Osasco, Greater São Paulo.
Parque Geológico do Varvito
Banded rock walls line a former quarry in Itu, where Parque Geológico do Varvito shows off varvite, sediment that settled in glacial lakes some 280 million years ago.
Pinacoteca Municipal de Bauru
The Pinacoteca Municipal de Bauru is an art museum in the city of Bauru, in the interior of São Paulo state.
Headquarters of Fazenda Divisa
The Headquarters of Fazenda Divisa (Casa-Sede da Fazenda Divisa) is a historic building in Bauru, protected by the city's cultural heritage council since 2005.
Thermas Acqualinda
Thermas Acqualinda is a themed thermal water park in Andradina, São Paulo state, built by politician and businessman Mário Celso Lopes as a leisure complex.
In Três Lagoas itself
Lagoa Maior
Lagoa Maior is the main of the three urban lagoons that give Três Lagoas, in Mato Grosso do Sul, its name; it spans about 418,000 square meters and is under three meters deep.
More drives to Três Lagoas
- Botucatu to Três Lagoas
- Ribeirão Preto to Três Lagoas
- Campinas to Três Lagoas
- Poços de Caldas to Três Lagoas
- Cascavel to Três Lagoas
- Mogi das Cruzes to Três Lagoas
From São Paulo to other places in Brazil
- São Paulo to Jundiaí
- São Paulo to Bragança Paulista
- São Paulo to Campinas
- São Paulo to Itu
- São Paulo to Mogi Guaçu
- São Paulo to São Carlos
Frequently asked questions
How long is the drive from São Paulo to Três Lagoas?
About 8 h 1 min of driving without stops, over 414 miles.
How far is Três Lagoas from São Paulo by car?
About 414 miles (666 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from São Paulo to Três Lagoas?
The U.S. State Department rates Brazil Level 2: Exercise Increased Caution. Read the full advisory before you go.
What roads does the drive from São Paulo to Três Lagoas use?
In order: SP-015, SP-280, SP-209, SP-300 and BR-262. The road-by-road table above shows the route miles for each one.
What are good stops between São Paulo and Três Lagoas?
Closest to the road: Dimitri Sensaud de Lavaud Museum (museum, mile 12, 0.8 mi from the route); Headquarters of Fazenda Divisa (historic estate, mile 210, 1 mi from the route); Thermas Acqualinda (water park, mile 388, 0.2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.