By road, Santos and Assis are about 313 miles (503 km) apart, or roughly 5 h 54 min of driving.
- Level 4: Do Not Travel in Brazil: informal housing developments (favelas, vilas, comunidades or conglomerados).
Full advisory: Brazil. Advisory issued: Brazil August 31, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Brazil: “Road maintenance is inadequate in many areas.”
| Distance | 313 mi (503 km) |
|---|---|
| Drive time without stops | 5 h 54 min |
| Main roads, in order | SP-160 → SP-015 → SP-280 → SP-225 → SP-327 → SP-270 |
| States on the route | São Paulo |
| Fuel estimate (car at 25 mpg) | about 12.5 gal; actual use varies by vehicle and traffic |
| Stops listed below | 9 |
The Santos–Assis drive in a few lines
SP-280 (188 mi) and SP-270 (36 mi) carry about 72% of the 313 miles. Of the 9 stops listed below, 2 are within a mile of the road.
Which roads connect Santos and Assis
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–6 | 6 | São Paulo |
| SP-160 | 6–41 | 35 | São Paulo |
| local roads | 41–47 | 6 | São Paulo |
| SP-015 | 47–53 | 6 | São Paulo |
| SP-280 | 53–241 | 188 | São Paulo |
| SP-225 | 241–253 | 12 | São Paulo |
| SP-327 | 253–273 | 20 | São Paulo |
| SP-270 | 273–309 | 36 | São Paulo |
| local roads | 309–313 | 4 | São Paulo |
Where to stop on the way to Assis
- Right off the route (under 1 mile): Museu de Ciências da Universidade de São Paulo (mile 40), Museu da Lâmpada (mile 43)
- Nature and outdoors: Parque Geológico do Varvito (mile 96)
- Museums and history: Pinacoteca de São Bernardo do Campo (mile 36), Museu de Ciências da Universidade de São Paulo (mile 40), Museu da Lâmpada (mile 43), Museum of Fine Arts of São Paulo (mile 44), Museum of Archeology and Ethnology of the University of São Paulo (mile 52)
- With kids: Cidade da Criança (mile 36)
Cidade da Criança
Opened on October 10, 1968, Cidade da Criança in São Bernardo do Campo was the first theme park in Brazil and Latin America and sits behind the former Vera Cruz Film Studios.
Pinacoteca de São Bernardo do Campo
This municipal art gallery in São Bernardo do Campo studies and shows modern and contemporary art, with works by Tomie Ohtake, Waldomiro de Deus and Wesley Duke Lee in its collection.
Museu de Ciências da Universidade de São Paulo
The University of São Paulo's Science Museum, created in 2005, brings the exact, human and natural sciences, technology and the arts to the public beyond the campus.
Museu da Lâmpada
Opened in São Paulo on April 15, 2012, Museu da Lâmpada traces the history of lighting and the lamp back to prehistoric times, using items collected by the electrical supplier GIMAWA.
Museum of Fine Arts of São Paulo
A university museum in the Vila Mariana neighborhood of São Paulo, the Museum of Fine Arts of São Paulo opened in September 2007.
Teatro Augusta
Teatro Augusta is a theater in São Paulo's Baixo Augusta area, in Cerqueira César, with 302 seats in its Sala Paulo Goulart and a smaller multipurpose experimental room.
Centro Cultural Fiesp
The Centro Cultural Fiesp, also named for Ruth Cardoso, is a cultural center in the city of São Paulo that opened in 1964.
Museum of Archeology and Ethnology of the University of São Paulo
Run as a department of the University of São Paulo, this museum of archaeology and ethnology focuses on research, teaching, and sharing cultural and scientific knowledge with the public.
Parque Geológico do Varvito
Glacial lakes about 280 million years ago left behind the layered varvite now visible at this closed quarry in Itu. The site is a protected geological monument, and visitors can walk right past its walls.
Once you reach Assis
Estação de Assis
Assis's railway station joined the company's trunk line in 1914 and got its current building in 1926; the original station was adapted as housing for traffic staff in 1927.
Museu de Arte Primitiva de Assis
Assis's museum of primitive (naïve) art, founded by José Nazareno Mimessi, sits inside Parque do Buracão, an ecological park, in its own climate-controlled building opened in 1999. It is run by the city's culture department.
More drives to Assis
- Jaú to Assis
- Araraquara to Assis
- Ribeirão Preto to Assis
- São Paulo to Assis
- Mogi Guaçu to Assis
- Poços de Caldas to Assis
From Santos to other places in Brazil
- Santos to Itanhaém
- Santos to Bragança Paulista
- Santos to Itu
- Santos to Limeira
- Santos to Mogi Guaçu
- Santos to Botucatu
Frequently asked questions
How long does it take to drive from Santos to Assis?
About 5 h 54 min of driving without stops, over 313 miles.
How far is Assis from Santos by car?
About 313 miles (503 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from Santos to Assis?
The U.S. State Department rates Brazil Level 2: Exercise Increased Caution. Read the full advisory before you go.
What roads does the drive from Santos to Assis use?
In order: SP-160, SP-015, SP-280, SP-225, SP-327 and SP-270. The road-by-road table above shows the route miles for each one.
What are good stops between Santos and Assis?
Closest to the road: Museu de Ciências da Universidade de São Paulo (museum, mile 40, 0.6 mi from the route); Museu da Lâmpada (museum, mile 43, 0.9 mi from the route); Museum of Archeology and Ethnology of the University of São Paulo (ethnographic museum, mile 52, 1 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.