The Wayro route from Safford to Guaymas is 415 miles (668 km), about 7 h 38 min of driving without stops. The U.S.–Mexico border is at about mile 155 on this route, near the Nogales port of entry.
| Distance | 415 mi (668 km) |
|---|---|
| Driving time, no stops | 7 h 38 min |
| Main roads, in order | US-191 → I-10 → AZ 90 → AZ 82 → MEX-15 → MEX-15D |
| Border crossing | about mile 155 of this route, Arizona → Sonora (near the Nogales, AZ port of entry) |
| Mexican states on the route | Sonora (Level 3) |
| Toll roads | MEX-15D |
| Fuel estimate (car at 25 mpg) | about 16.6 gal; actual use varies by vehicle and traffic |
| Stops listed below | 5 |
Crossing into Mexico: what you need for Guaymas
| Passport | Passport book or passport card to enter Mexico by land |
|---|---|
| FMM entry permit | Required for this trip: Guaymas is well beyond the 12-mile (20 km) border zone where the permit is not needed |
| Temporary vehicle import permit (TIP) | Not needed: Guaymas is inside Sonora's free zone (west of Highway 15 as far south as Empalme, plus a strip along the border that includes Cananea). Going farther south or east of Highway 15 requires a permit |
| Mexican auto insurance | Required for all vehicles: buy a Mexican policy before you cross |
Sources: U.S. State Department, Mexico travel information (updated August 11, 2026); permits are issued by Banjercito. Sonora free zone: Explore Sonora.
Crossing at Nogales
Nogales, Arizona, and Nogales, Sonora, share several crossings: DeConcini downtown is the main gateway for visitors and daily crossers, Morley Gate nearby serves pedestrians, and Mariposa on the west side handles commercial trucks. The city is also home to Arizona's only rail crossing.
What the drive from Safford to Guaymas is like
MEX-15D (138 mi) and MEX-15 (122 mi) carry about 63% of the 415 miles. The U.S. part of the drive runs through Arizona for about 155 miles; after the border at Nogales you have about 260 miles left in Mexico. The Mexican leg uses MEX-15D, a toll highway (cuota). Of the 5 stops listed below, 3 are within a mile of the road.
The route from Safford to Guaymas, road by road
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| US-191 | 0–34 | 34 | Arizona |
| I-10 | 34–83 | 49 | Arizona |
| connecting roads | 83–84 | 1 | Arizona |
| AZ 90 | 84–103 | 19 | Arizona |
| AZ 82 | 103–153 | 50 | Arizona |
| connecting roads | 153–154 | 1 | Arizona |
| MEX-15 | 154–206 | 52 | Arizona, Sonora |
| MEX-15D | 206–344 | 138 | Sonora |
| MEX-15 | 344–414 | 70 | Sonora |
| local roads | 414–415 | 1 | Sonora |
- Mile 155 of this route: Arizona → Sonora (international border)
Stops between Safford and Guaymas
- Right off the route (under 1 mile): The Thing (mile 63), Texas Canyon (mile 66), Kartchner Caverns State Park (mile 93)
- Nature and outdoors: Texas Canyon (mile 66), Kartchner Caverns State Park (mile 93), Patagonia Lake State Park (mile 140)
- Museums and history: Rex Allen Arizona Cowboy Museum and Willcox Cowboy Hall of Fame (mile 46)
Rex Allen Arizona Cowboy Museum and Willcox Cowboy Hall of Fame
This Willcox museum honors Rex Allen, the "Arizona Cowboy," with memorabilia from his rodeo, radio, film, and TV career; across the street stands his bronze statue, with his horse KoKo buried at its base.
The Thing
Billboards along I-10 between El Paso and Tucson build up to this bright yellow stop about an hour east of Tucson, where a small museum shows off a collection of bizarre objects and the gift shop sells odd souvenirs.
Texas Canyon
Just off Interstate 10 between Benson and Willcox, giant granite boulders scatter across high-desert grassland. The Amerind Foundation's Texas Canyon Nature Preserve offers about 6 miles of gentle trails past balanced rocks and spires.
Kartchner Caverns State Park
Discovered in 1974 in the Whetstone Mountains, this living limestone cave is seen on guided tours past formations like Kubla Khan, a 58-foot column, and a 21-foot soda straw; above ground, the park has trails and camping.
Patagonia Lake State Park
Tucked into the rolling hills of southeastern Arizona, this lake park draws visitors for fishing, water skiing, camping and a creek trail where birders watch for herons, vermilion flycatchers and hummingbirds.
When you get to Guaymas
Guaymas is a working port on Sonora's Gulf of California coast, where the desert mountains drop straight to the sea. Its old downtown keeps a cluster of historic churches and a waterfront plaza, and the resort area of San Carlos sits just up the coast.
- Templo de San Fernando: The church of San Fernando is one of the historic landmarks of downtown Guaymas. source
- Plaza 13 de Julio: This downtown plaza is one of the public squares highlighted by Mexico's Culture Ministry among Guaymas' points of interest. source
- Templo de San José de Guaymas: The parish church of San José is another stop on a walk through the city's historic churches, along with the Sagrado Corazón church. source
More drives to Guaymas
- Gilbert, AZ to Guaymas
- Goodyear, AZ to Guaymas
- Cottonwood, AZ to Guaymas
- Clarkdale, AZ to Guaymas
- Sierra Vista, AZ to Guaymas
- Tucson, AZ to Guaymas
From Safford to other places in Mexico
- Safford, AZ to San Felipe
- Safford, AZ to Chihuahua
- Safford, AZ to Nuevo Casas Grandes
- Safford, AZ to Mexicali
- Safford, AZ to Ciudad Juárez
- Safford, AZ to Ciudad Obregón
All routes to Guaymas, border crossings and permits in one place: Driving to Guaymas, Mexico from the U.S.
Continue Your Adventure
Frequently asked questions
How long is the drive from Safford to Guaymas?
About 7 h 38 min of driving without stops, over 415 miles.
How far is Guaymas from Safford by car?
About 415 miles (668 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Where does the Safford to Guaymas drive cross into Mexico?
At about mile 155 of this route, from Arizona into Sonora, near the Nogales port of entry.
Do I need a permit to drive my car from Safford to Guaymas?
No vehicle permit is needed. Guaymas is inside Sonora's free zone (west of Highway 15 as far south as Empalme, plus a strip along the border that includes Cananea). Going farther south or east of Highway 15 requires a permit. You also need Mexican auto insurance and a passport book or card. An FMM entry permit is required too.
Is it safe to drive from Safford to Guaymas?
The U.S. State Department rates Sonora Level 3: Reconsider Travel (advisory issued May 29, 2026). Read the full advisory before you go.
What roads does the drive from Safford to Guaymas use?
In order: US-191, I-10, AZ 90, AZ 82, MEX-15 and MEX-15D. The road-by-road table above shows the route miles and states for each one.
What are good stops between Safford and Guaymas?
Closest to the road: The Thing (roadside attraction, mile 63, 0.2 mi from the route); Texas Canyon (canyon, mile 66, 0.3 mi from the route); Kartchner Caverns State Park (state park, mile 93, 0.3 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway mile markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route (roughly 2 to 7 miles depending on the type, farther for World Heritage sites): at least one strong stop for each stretch of the drive, then the best-known places nearest the road, with no more than five of one type, up to nine in all. Places that are closed, private or not open to visitors are removed. Place and city descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on September 29, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.