The Wayro route from Reynosa to Zacatecas is 423 miles (681 km), about 8 h 1 min of driving without stops.
What the State Department tells travelers on this route:
- Nuevo León: “Those traveling between the U.S. border and Monterrey on highways 85/85D, 54, and 40/40D should exercise caution and avoid travel after dark.”
- Nuevo León: “Armed robberies and carjackings have occurred along these highways even during daylight hours.”
| Total distance | 423 mi (681 km) |
|---|---|
| Time at the wheel, no stops | 8 h 1 min |
| Main roads, in order | MEX-40 → MEX-40D → MEX-54 → MEX-45 |
| Mexican states on the route | Tamaulipas, Nuevo León, Coahuila, Zacatecas |
| Toll roads (as marked in OpenStreetMap) | MEX-40D |
| Fuel estimate (car at 25 mpg) | about 16.9 gal; actual use varies by vehicle and traffic |
| Stops listed below | 4 |
Driving this route in a car with U.S. plates
| Temporary vehicle import permit (TIP) | Required: this route is outside the zones where U.S.-registered cars can skip the temporary import permit (Baja California, Baja California Sur and part of Sonora) |
|---|---|
| Mexican auto insurance | Required for all vehicles: buy a Mexican policy before you drive |
Sources: U.S. State Department, Mexico travel information (updated August 11, 2026); permits are issued by Banjercito.
What the drive from Reynosa to Zacatecas is like
MEX-54 (209 mi) and MEX-40D (159 mi) carry about 87% of the 423 miles. It runs through 4 states: Tamaulipas, Nuevo León, Coahuila, Zacatecas. OpenStreetMap marks tolled sections on MEX-40D. Of the 4 stops listed below, 3 are within a mile of the road.
Road-by-road breakdown: Reynosa to Zacatecas
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–1 | 1 | Tamaulipas |
| MEX-40 | 1–30 | 29 | Tamaulipas, Nuevo León |
| MEX-40D | 30–126 | 96 | Nuevo León |
| MEX-40 | 126–132 | 6 | Nuevo León |
| local roads | 132–139 | 7 | Nuevo León |
| connecting roads | 139–142 | 3 | Nuevo León |
| MEX-40D | 142–205 | 63 | Nuevo León, Coahuila |
| MEX-54 | 205–414 | 209 | Coahuila, Zacatecas |
| MEX-45 | 414–423 | 9 | Zacatecas |
- Mile 19 of this route: Tamaulipas → Nuevo León (state line)
- Mile 167 of this route: Nuevo León → Coahuila (state line)
- Mile 244 of this route: Coahuila → Zacatecas (state line)
What to see on the way from Reynosa to Zacatecas
- Right off the route (under 1 mile): Cineteca Nuevo León Alejandra Rangel Hinojosa (mile 135), Basilica of Guadalupe, Monterrey (mile 137), Palacio del Obispado (mile 139)
- Museums and history: Basilica of Guadalupe, Monterrey (mile 137), Palacio del Obispado (mile 139)
Cineteca Nuevo León Alejandra Rangel Hinojosa
Cineteca Nuevo León Alejandra Rangel Hinojosa is a film archive and cinematheque in the city of Monterrey, Nuevo León, Mexico.
Basilica of Guadalupe, Monterrey
The Basilica of Guadalupe, also called the Santuario de Nuestra Señora de Guadalupe, is a Roman Catholic church in the Monterrey metropolitan area of Nuevo León.
Palacio del Obispado
Completed in 1787 for Bishop Rafael José Verger, this Baroque palace served as a fortress in 1846, during the French intervention, and in the Revolution. The building is home to INAH's regional museum of Nuevo León.
Cerro La Mota
Cerro La Mota, also called Sierra Nacataz, covers about 9,400 hectares of mountains in García and Santa Catarina, with other protected ranges all around it.
Once you reach Zacatecas
Zacatecas climbs the steep slopes of a narrow valley between the Bufa and Grillo hills in north-central Mexico. Founded in 1546 after the discovery of a rich silver lode, its historic center has been a UNESCO World Heritage Site since 1993, and the city is also part of the Camino Real de Tierra Adentro, the colonial silver route listed by UNESCO in 2010.
- Zacatecas Cathedral: Built between 1730 and 1760, the cathedral dominates downtown with Baroque façades that mix European and Indigenous decorative elements. source
- Teatro Calderón: The downtown theater dates from 1834 and is one of the civic landmarks UNESCO highlights in the historic center. source
- Mercado González Ortega: The iron-framed market building from 1886 stands in the historic center near the cathedral. source
Cathedral Basilica of Zacatecas
Dedicated to the Virgin of the Assumption, the Cathedral of Zacatecas is the main church of the Diocese of Zacatecas.
Manuel Felguérez Museum
A former seminary begun in 1870, later a barracks and then a prison until 1995, now holds Zacatecas' Museo de Arte Abstracto Manuel Felguérez, devoted to abstract art and to the work of the painter it's named after.
Teatro Fernando Calderón
Built between 1891 and 1897 to plans by architect George Edward King, Zacatecas' Teatro Calderón honors playwright Fernando Calderón and witnessed violent events during the Toma de Zacatecas.
More drives to Zacatecas
- Del Rio, TX to Zacatecas
- South Padre Island, TX to Zacatecas
- McAllen, TX to Zacatecas
- Laredo, TX to Zacatecas
- Corpus Christi, TX to Zacatecas
- Brownsville, TX to Zacatecas
From Reynosa to other places in Mexico
- Reynosa to Arteaga
- Reynosa to General Cepeda
- Reynosa to Parras de la Fuente
- Reynosa to San Pedro, Mexico
- Reynosa to Viesca
- Reynosa to Gómez Palacio
Coming to Zacatecas from the United States? Border crossings, permits and routes from U.S. cities: Driving to Zacatecas, Mexico from the U.S.
Continue Your Adventure
Frequently asked questions
How long does it take to drive from Reynosa to Zacatecas?
About 8 h 1 min of driving without stops, over 423 miles.
What is the driving distance from Reynosa to Zacatecas?
About 423 miles (681 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Do I need a permit to drive my U.S. car from Reynosa to Zacatecas?
Yes. A temporary vehicle import permit (TIP) is required for a U.S.-registered car on this route, which is outside the zones where it can be skipped. Mexican auto insurance is required for every vehicle.
Is it safe to drive from Reynosa to Zacatecas?
The U.S. State Department rates Tamaulipas Level 4: Do Not Travel; Nuevo León Level 2: Exercise Increased Caution; Coahuila Level 3: Reconsider Travel; Zacatecas Level 4: Do Not Travel (advisory issued May 29, 2026). Read the full advisory before you go.
What roads does the drive from Reynosa to Zacatecas use?
In order: MEX-40, MEX-40D, MEX-54 and MEX-45. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from Reynosa to Zacatecas?
Closest to the road: Cineteca Nuevo León Alejandra Rangel Hinojosa (cinematheque, mile 135, 0.4 mi from the route); Basilica of Guadalupe, Monterrey (basilica, mile 137, 0.4 mi from the route); Palacio del Obispado (museum, mile 139, 0.2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on September 29, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.