Plan the Santa Fe to Mercedes, Uruguay drive: 234 miles (377 km), 4 h 48 min without stops, the border crossing, U.S. travel advisory and 3 stops.

Driving from Santa Fe to Melo, Uruguay: 473 miles and about 10 h 29 min behind the wheel. Where you cross into Uruguay, what to bring, and 6 stops on the way.

Driving from Santa Fe to Tacuarembó, Uruguay: 348 miles and about 7 h 30 min behind the wheel. Where you cross into Uruguay, what to bring, and 4 stops.

Plan the Santa Fe to Rivera, Uruguay drive: 417 miles (671 km), 8 h 51 min without stops, the border crossing, U.S. travel advisory and 6 stops.

Plan the Santa Fe to Maldonado, Uruguay drive: 476 miles (766 km), 9 h 53 min without stops, the border crossing, U.S. travel advisory and 8 stops.

Plan the Santa Fe to Salto, Uruguay drive: 203 miles (327 km), 4 h 9 min without stops, the border crossing, U.S. travel advisory and 3 stops.

Driving from Montevideo to Santa Fe, Argentina: 408 miles and about 8 h 40 min behind the wheel. Where you cross into Argentina, what to bring, and 8 stops.

Plan the Corrientes to Conchillas, Uruguay drive: 558 miles (898 km), 11 h 22 min without stops, the border crossing, U.S. travel advisory and 9 stops.

Driving from Corrientes to Carmelo, Uruguay: 535 miles and about 10 h 47 min behind the wheel. Where you cross into Uruguay, what to bring, and 8 stops.

Plan the Corrientes to Fray Bentos, Uruguay drive: 457 miles (736 km), 8 h 55 min without stops, the border crossing, U.S. travel advisory and 3 stops.