Plan the Santa Fe to Atlántida, Uruguay drive: 426 miles (685 km), 8 h 57 min without stops, the border crossing, U.S. travel advisory and 7 stops.

Plan the Santa Fe to Nueva Helvecia, Uruguay drive: 326 miles (524 km), 7 h 6 min without stops, the border crossing, U.S. travel advisory and 5 stops.

Plan the Santa Fe to Piriápolis, Uruguay drive: 457 miles (735 km), 9 h 40 min without stops, the border crossing, U.S. travel advisory and 9 stops.

Driving from Santa Fe to Río Branco, Uruguay: 529 miles and about 11 h 53 min behind the wheel. Where you cross into Uruguay, what to bring, and 8 stops.

Driving from Santa Fe to Carmelo, Uruguay: 299 miles and about 6 h 25 min behind the wheel. Where you cross into Uruguay, what to bring, and 7 stops.

Driving from Santa Fe to Fray Bentos, Uruguay: 221 miles and about 4 h 33 min behind the wheel. Where you cross into Uruguay, what to bring, and 2 stops.

Plan the Santa Fe to Rocha, Uruguay drive: 519 miles (835 km), 10 h 58 min without stops, the border crossing, U.S. travel advisory and 9 stops.

Santa Fe to Colonia del Sacramento, Uruguay: 347 miles (558 km), about 7 h 35 min of driving, crossing at the Gualeguaychú–Fray Bentos bridge. Entry rules.

Driving from Santa Fe to Minas, Uruguay: 464 miles and about 9 h 52 min behind the wheel. Where you cross into Uruguay, what to bring, and 9 stops on the way.

Plan the Santa Fe to Durazno, Uruguay drive: 345 miles (556 km), 7 h 2 min without stops, the border crossing, U.S. travel advisory and 4 stops.