3 stops between Santa Maria, Brazil and Santa Cruz do Sul, plus the route: 89 miles (144 km), about 2 h 11 min of driving and the U.S. travel advisory level.
Driving from Santa Cruz do Sul to Guaíra: 529 miles, roughly 11 h 36 min without stops. Road by road, 3 places to stop and the State Department advisory.
Driving from Porto Alegre to Bento Gonçalves: 76 miles, roughly 1 h 59 min without stops. Road by road, 4 places to stop and the State Department advisory.
Caxias do Sul to Francisco Beltrão: 373 miles (600 km), about 8 h 53 min of driving. The route, U.S. travel advisory for Brazil and 3 stops on the way.