Santa Cruz do Sul to Guaíra is about 529 road miles (851 km): roughly 11 h 36 min at the wheel if you don't stop.
- Level 4: Do Not Travel in Brazil: Within 100 miles (160 km) of Brazil's land borders with Bolivia, Colombia, Guyana, French Guiana, Paraguay, Peru, Suriname, and Venezuela. This drive passes within 100 miles of the border with Paraguay.
- Level 4: Do Not Travel in Brazil: informal housing developments (favelas, vilas, comunidades or conglomerados).
This route passes through or near an area the State Department rates Do Not Travel. Read the full advisory before you plan this drive: Brazil. Advisory issued: Brazil August 31, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Brazil: “Road maintenance is inadequate in many areas.”
| Distance | 529 mi (851 km) |
|---|---|
| Driving time, no stops | 11 h 36 min |
| Main roads, in order | RSC-287 → RSC-153 → BR-153 → BR-386 → BR-158 → SC-160 → PR-180 → PR-483 → PR-182 → BR-163 |
| States on the route | Rio Grande do Sul, Santa Catarina, Paraná |
| Fuel estimate (car at 25 mpg) | about 21.2 gal; actual use varies by vehicle and traffic |
| Stops listed below | 3 |
On the road from Santa Cruz do Sul to Guaíra
BR-163 (134 mi) and BR-153 (92 mi) carry about 43% of the 529 miles. It runs through 3 states: Rio Grande do Sul, Santa Catarina, Paraná. None of the 3 stops below is right on the road, so plan each as a short side trip.
Which roads connect Santa Cruz do Sul and Guaíra
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–3 | 3 | Rio Grande do Sul |
| RSC-287 | 3–10 | 7 | Rio Grande do Sul |
| RSC-153 | 10–84 | 74 | Rio Grande do Sul |
| connecting roads | 84–86 | 2 | Rio Grande do Sul |
| BR-153 | 86–178 | 92 | Rio Grande do Sul |
| BR-386 | 178–239 | 61 | Rio Grande do Sul |
| BR-158 | 239–272 | 33 | Santa Catarina |
| local roads | 272–281 | 9 | Santa Catarina |
| connecting roads | 281–283 | 2 | Santa Catarina |
| SC-160 | 283–305 | 22 | Santa Catarina |
| connecting roads | 305–307 | 2 | Santa Catarina |
| PR-180 | 307–327 | 20 | Santa Catarina, Paraná |
| connecting roads | 327–331 | 4 | Paraná |
| PR-483 | 331–347 | 16 | Paraná |
| PR-182 | 347–392 | 45 | Paraná |
| BR-163 | 392–526 | 134 | Paraná |
| local roads | 526–529 | 3 | Paraná |
- Mile 239 of this route: Rio Grande do Sul → Santa Catarina (state line)
- Mile 309 of this route: Santa Catarina → Paraná (state line)
What to see on the way from Santa Cruz do Sul to Guaíra
- Nature and outdoors: Parque Estadual do Papagaio-Charão (Ex-Parque Est. Rondinha) (mile 155)
- Museums and history: Christ the King Cathedral, Toledo (mile 464), Museu Histórico Willy Barth (mile 467)
Parque Estadual do Papagaio-Charão (Ex-Parque Est. Rondinha)
Created in 1982 on 1,000 hectares, this Rio Grande do Sul state park (formerly Rondinha Forest Park) protects a transition between savanna and araucaria forest, home to the threatened red-spectacled parrot and the Butia paraguayensis palm.
Christ the King Cathedral, Toledo
In the center of Toledo, Paraná, Christ the King Cathedral is the Catholic seat of the Diocese of Toledo in Brazil.
Museu Histórico Willy Barth
Museu Histórico Willy Barth is an art and history museum in Toledo, western Paraná, with roughly 45,000 items, including documents, photographs and historical objects.
More drives to Guaíra
- Bento Gonçalves to Guaíra
- Santa Maria, Brazil to Guaíra
- Guarapuava to Guaíra
- Ponta Grossa to Guaíra
- Curitiba to Guaíra
- Paranaguá to Guaíra
From Santa Cruz do Sul to other places in Brazil
- Santa Cruz do Sul to Tubarão
- Santa Cruz do Sul to Santana do Livramento
- Santa Cruz do Sul to Chuí
- Santa Cruz do Sul to Salto, Uruguay
- Santa Cruz do Sul to Maldonado, Uruguay
- Santa Cruz do Sul to Rivera, Uruguay
Frequently asked questions
How long does it take to drive from Santa Cruz do Sul to Guaíra?
About 11 h 36 min of driving without stops, over 529 miles.
What is the driving distance from Santa Cruz do Sul to Guaíra?
About 529 miles (851 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from Santa Cruz do Sul to Guaíra?
The U.S. State Department rates Brazil Level 2: Exercise Increased Caution. Parts of this route are in or near areas rated Level 4: Do Not Travel (Brazil: Within 100 miles (160 km) of Brazil's land borders with Bolivia, Colombia, Guyana, French Guiana, Paraguay, Peru, Suriname, and Venezuela). Read the full advisory before you go.
Which highways go from Santa Cruz do Sul to Guaíra?
In order: RSC-287, RSC-153, BR-153, BR-386, BR-158, SC-160, PR-180, PR-483, PR-182 and BR-163. The road-by-road table above shows the route miles for each one.
What are good stops between Santa Cruz do Sul and Guaíra?
Closest to the road: Parque Estadual do Papagaio-Charão (Ex-Parque Est. Rondinha) (state park, mile 155, 6 mi from the route); Christ the King Cathedral, Toledo (cathedral, mile 464, 2 mi from the route); Museu Histórico Willy Barth (museum, mile 467, 3 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.