San Nicolás de los Arroyos to Colón, Argentina: 232 miles (373 km), about 4 h 26 min of driving. The route, U.S. travel advisory for Argentina and 5 stops.
Driving from Santa Fe to Colón, Argentina: 198 miles, roughly 3 h 53 min without stops. Road by road, 2 places to stop and the State Department advisory.
Rosario, Argentina to Colón, Argentina: 190 miles (305 km), about 3 h 46 min of driving. The route, U.S. travel advisory for Argentina and 3 stops on the way.
Driving from Bahía Blanca to Gualeguaychú: 526 miles, roughly 10 h 10 min without stops. Road by road, 6 places to stop and the State Department advisory.