The Wayro route from Mexico City to Guadalupe, Zacatecas is 376 miles (605 km), about 6 h 51 min of driving without stops.
| Distance | 376 mi (605 km) |
|---|---|
| Driving time, no stops | 6 h 51 min |
| Main roads, in order | Viaducto → Periférico → MEX-57 → MEX-47D → MEX-45D → MEX-45 |
| Mexican states on the route | Mexico City (Level 2), State of Mexico (Level 2), Hidalgo (Level 2), Querétaro (Level 2), Guanajuato (Level 3), Jalisco (Level 3), Aguascalientes (Level 2), Zacatecas (Level 4) |
| Toll roads | MEX-57D, MEX-47D, MEX-45D |
| Fuel estimate (car at 25 mpg) | about 15.0 gal; actual use varies by vehicle and traffic |
| Stops listed below | 9 |
Driving this route in a car with U.S. plates
| Temporary vehicle import permit (TIP) | Required: this route is outside the zones where U.S.-registered cars can skip the temporary import permit (Baja California, Baja California Sur and part of Sonora) |
|---|---|
| Mexican auto insurance | Required for all vehicles: buy a Mexican policy before you drive |
Sources: U.S. State Department, Mexico travel information (updated August 11, 2026); permits are issued by Banjercito.
What the drive from Mexico City to Guadalupe, Zacatecas is like
MEX-45D (162 mi) and MEX-57 (70 mi) carry about 62% of the 376 miles. MEX-47D, MEX-45D are toll highways (cuota); MEX-57, MEX-45 are free federal roads (libre). It runs through 8 states: Mexico City, State of Mexico, Hidalgo, Querétaro, Guanajuato, Jalisco, Aguascalientes, Zacatecas. Of the 9 stops listed below, 2 are within a mile of the road.
The route from Mexico City to Guadalupe, Zacatecas, road by road
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–2 | 2 | Mexico City |
| Viaducto | 2–6 | 4 | Mexico City |
| Periférico | 6–24 | 18 | Mexico City, State of Mexico |
| MEX-57 | 24–94 | 70 | State of Mexico, Hidalgo, Querétaro |
| MEX-47D | 94–148 | 54 | Querétaro, Guanajuato |
| MEX-45D | 148–289 | 141 | Guanajuato, Jalisco |
| MEX-45 | 289–319 | 30 | Jalisco, Aguascalientes |
| local roads | 319–322 | 3 | Aguascalientes |
| MEX-45 | 322–350 | 28 | Aguascalientes, Zacatecas |
| MEX-45D | 350–371 | 21 | Zacatecas |
| local roads | 371–376 | 5 | Zacatecas |
- Mile 9 of this route: Mexico City → State of Mexico (state line)
- Mile 41 of this route: State of Mexico → Hidalgo (state line)
- Mile 60 of this route: Hidalgo → State of Mexico (state line)
- Mile 93 of this route: State of Mexico → Querétaro (state line)
- Mile 135 of this route: Querétaro → Guanajuato (state line)
- Mile 244 of this route: Guanajuato → Jalisco (state line)
- Mile 293 of this route: Jalisco → Aguascalientes (state line)
- Mile 346 of this route: Aguascalientes → Zacatecas (state line)
Stops between Mexico City and Guadalupe, Zacatecas
- Right off the route (under 1 mile): Acuario Inbursa (mile 9), Museo Regional de Aguascalientes (mile 307)
- Nature and outdoors: Bicentennial Park (mile 11), Los Remedios National Park (mile 12), Tula National Park (mile 56), Cerro de las Campanas (mile 136)
- Museums and history: Santa Cecilia Acatitlan (mile 18), Cristo Rey (mile 19), Cuautitlán Cathedral (mile 27), Museo Regional de Aguascalientes (mile 307)
- With kids: Acuario Inbursa (mile 9)
Acuario Inbursa
In the Nuevo Polanco area of Mexico City, Acuario Inbursa spreads across about 3,500 square meters of exhibits holding some 1.6 million liters of seawater.
Bicentennial Park
On the line between the Azcapotzalco and Miguel Hidalgo boroughs, Bicentennial Park (Parque Bicentenario) is a park in the western part of Mexico City.
Los Remedios National Park
Los Remedios National Park, created by federal decree in 1938, covers about 400 hectares on the far western side of Naucalpan, just northwest of Mexico City.
Santa Cecilia Acatitlan
Santa Cecilia Acatitlan is an early Aztec archaeological zone in Tlalnepantla de Baz, about 10 km northwest of Mexico City, once on the shore of Lake Texcoco.
Cristo Rey
Begun in 1975 and inaugurated in 1981, this colossal Cristo Rey statue stands on Cerro Cola de Caballo in the Sierra de Guadalupe, within the Jardines del Recuerdo cemetery in Tlalnepantla.
Cuautitlán Cathedral
Cuautitlán's St. Bonaventure Cathedral (Catedral de San Buenaventura) is a Catholic church that forms part of the convent of the same name in this State of Mexico municipality.
Tula National Park
This park protects the ruins of Tula, ancient capital of the Toltecs. Walk up to the main pyramid to stand beside the Atlantes, basalt warrior figures more than four meters tall, and look for the Coatepantli wall's reliefs of snakes devouring skeletons.
Cerro de las Campanas
Rising within Querétaro City, the Cerro de las Campanas is a hill that is protected as a Mexican national park.
Museo Regional de Aguascalientes
An early 20th-century building by self-taught architect Refugio Reyes holds this INAH museum of Aguascalientes history, with fossils, archaeological finds, colonial paintings by Juan Correa and more than 300 devotional ex-voto paintings.
When you get to Guadalupe, Zacatecas
Museo Toma de Zacatecas
On the Cerro de la Bufa, this museum explains the military and social story behind the Taking of Zacatecas during the Mexican Revolution, along with glimpses of daily life in the city at the time.
Cathedral Basilica of Zacatecas
Dedicated to the Virgin of the Assumption, the Cathedral of Zacatecas is the main church of the Diocese of Zacatecas.
Manuel Felguérez Museum
A former seminary begun in 1870, later a barracks and then a prison until 1995, now holds Zacatecas' Museo de Arte Abstracto Manuel Felguérez, devoted to abstract art and to the work of the painter it's named after.
More drives to Guadalupe, Zacatecas
- Guadalajara to Guadalupe, Zacatecas
- Uruapan to Guadalupe, Zacatecas
- Morelia to Guadalupe, Zacatecas
- Salamanca to Guadalupe, Zacatecas
- Querétaro to Guadalupe, Zacatecas
- San Juan del Río to Guadalupe, Zacatecas
From Mexico City to other places in Mexico
- Mexico City to Metepec
- Mexico City to Toluca
- Mexico City to Cuernavaca
- Mexico City to Atlatlahucan
- Mexico City to Malinalco
- Mexico City to Cuautla
Continue Your Adventure
Frequently asked questions
How long is the drive from Mexico City to Guadalupe, Zacatecas?
About 6 h 51 min of driving without stops, over 376 miles.
How far is Guadalupe, Zacatecas from Mexico City by car?
About 376 miles (605 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Do I need a permit to drive my U.S. car from Mexico City to Guadalupe, Zacatecas?
Yes. A temporary vehicle import permit (TIP) is required for a U.S.-registered car on this route, which is outside the zones where it can be skipped. Mexican auto insurance is required for every vehicle.
Is it safe to drive from Mexico City to Guadalupe, Zacatecas?
The U.S. State Department rates Mexico City Level 2: Exercise Increased Caution; State of Mexico Level 2: Exercise Increased Caution; Hidalgo Level 2: Exercise Increased Caution; Querétaro Level 2: Exercise Increased Caution; Guanajuato Level 3: Reconsider Travel; Jalisco Level 3: Reconsider Travel; Aguascalientes Level 2: Exercise Increased Caution; Zacatecas Level 4: Do Not Travel (advisory issued May 29, 2026). Read the full advisory before you go.
What roads does the drive from Mexico City to Guadalupe, Zacatecas use?
In order: Viaducto, Periférico, MEX-57, MEX-47D, MEX-45D and MEX-45. The road-by-road table above shows the route miles and states for each one.
What are good stops between Mexico City and Guadalupe, Zacatecas?
Closest to the road: Acuario Inbursa (public aquarium, mile 9, 0.6 mi from the route); Cuautitlán Cathedral (catholic cathedral, mile 27, 1 mi from the route); Museo Regional de Aguascalientes (history museum, mile 307, 0.2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway mile markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route (roughly 2 to 7 miles depending on the type, farther for World Heritage sites): at least one strong stop for each stretch of the drive, then the best-known places nearest the road, with no more than five of one type, up to nine in all. Places that are closed, private or not open to visitors are removed. Place and city descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on September 29, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.