The Wayro route from Mesa to Guaymas is 431 miles (693 km), about 7 h 26 min of driving without stops. The U.S.–Mexico border is at about mile 170 on this route, near the Nogales port of entry.
| Distance | 431 mi (693 km) |
|---|---|
| Driving time, no stops | 7 h 26 min |
| Main roads, in order | AZ 87 → AZ 587 → I-10 → I-19 → MEX-15D → MEX-15 |
| Border crossing | about mile 170 of this route, Arizona → Sonora (near the Nogales, AZ port of entry) |
| Mexican states on the route | Sonora (Level 3) |
| Toll roads | MEX-15D |
| Fuel estimate (car at 25 mpg) | about 17.2 gal; actual use varies by vehicle and traffic |
| Stops listed below | 7 |
Crossing into Mexico: what you need for Guaymas
| Passport | Passport book or passport card to enter Mexico by land |
|---|---|
| FMM entry permit | Required for this trip: Guaymas is well beyond the 12-mile (20 km) border zone where the permit is not needed |
| Temporary vehicle import permit (TIP) | Not needed: Guaymas is inside Sonora's free zone (west of Highway 15 as far south as Empalme, plus a strip along the border that includes Cananea). Going farther south or east of Highway 15 requires a permit |
| Mexican auto insurance | Required for all vehicles: buy a Mexican policy before you cross |
Sources: U.S. State Department, Mexico travel information (updated August 11, 2026); permits are issued by Banjercito. Sonora free zone: Explore Sonora.
Crossing at Nogales
Nogales, Arizona, and Nogales, Sonora, share several crossings: DeConcini downtown is the main gateway for visitors and daily crossers, Morley Gate nearby serves pedestrians, and Mariposa on the west side handles commercial trucks. The city is also home to Arizona's only rail crossing.
What the drive from Mesa to Guaymas is like
MEX-15D (146 mi) and MEX-15 (113 mi) carry about 60% of the 431 miles. The U.S. part of the drive runs through Arizona for about 170 miles; after the border at Nogales you have about 261 miles left in Mexico. The Mexican leg uses MEX-15D, a toll highway (cuota). Of the 7 stops listed below, 5 are within a mile of the road.
The route from Mesa to Guaymas, road by road
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–1 | 1 | Arizona |
| AZ 87 | 1–16 | 15 | Arizona |
| AZ 587 | 16–22 | 6 | Arizona |
| I-10 | 22–106 | 84 | Arizona |
| I-19 | 106–167 | 61 | Arizona |
| connecting roads | 167–170 | 3 | Arizona |
| MEX-15D | 170–178 | 8 | Sonora |
| MEX-15 | 178–221 | 43 | Sonora |
| MEX-15D | 221–359 | 138 | Sonora |
| MEX-15 | 359–429 | 70 | Sonora |
| local roads | 429–431 | 2 | Sonora |
- Mile 170 of this route: Arizona → Sonora (international border)
Stops between Mesa and Guaymas
- Right off the route (under 1 mile): Arizona Railway Museum (mile 12), Cathedral of Saint Augustine (mile 105), Mission San Xavier del Bac (mile 113), Tubac Presidio State Historic Park (mile 148), Tumacácori National Historical Park (mile 151)
- Nature and outdoors: Picacho Peak State Park (mile 66), Tubac Presidio State Historic Park (mile 148), Tumacácori National Historical Park (mile 151)
- Museums and history: Arizona Railway Museum (mile 12), Casa Grande Ruins National Monument (mile 38), Cathedral of Saint Augustine (mile 105), Mission San Xavier del Bac (mile 113), Tumacácori National Historical Park (mile 151)
Arizona Railway Museum
Founded in 1983, this volunteer-run nonprofit museum in Chandler displays restored railroad cars, including a 1906 Southern Pacific steam locomotive and a 1949 steam wrecking crane, both on the National Register of Historic Places.
Casa Grande Ruins National Monument
Standing for more than 600 years, the Great House is the centerpiece of this preserved Ancestral Sonoran Desert People's farming community near Coolidge. Visitors can also see the adobe walls of Compound A and a visitor center museum.
Picacho Peak State Park
Between Tucson and Casa Grande off I-10, the park surrounds 1,500-foot Picacho Peak, site of the 1862 Battle of Picacho Pass. Expect hiking trails, a campground, and spring displays of Mexican gold poppies.
Cathedral of Saint Augustine
Mother church of the Diocese of Tucson, this downtown cathedral wears a 1928 cast-stone façade inspired by the Cathedral of Querétaro, Mexico, decorated with yucca and saguaro blossoms and a depiction of Mission San Xavier del Bac.
Mission San Xavier del Bac
Founded in 1692 by Father Eusebio Kino on what is now the Tohono O'odham Nation's San Xavier Reservation, the mission's white church, built 1783–1797, is a National Historic Landmark and active parish open to visitors.
Tubac Presidio State Historic Park
Known as Arizona's first state park, dedicated in 1958, it preserves ruins of the Spanish presidio founded in 1752. See the museum, an underground archaeology exhibit, and an 1885 territorial schoolhouse.
Tumacácori National Historical Park
An adobe mission church anchors this park in the Santa Cruz River valley, where O'odham, Yaqui, and Apache people met Jesuit and Franciscan missionaries. Tour the mission grounds and visitor center, then walk the Anza Trail along the river.
When you get to Guaymas
Guaymas is a working port on Sonora's Gulf of California coast, where the desert mountains drop straight to the sea. Its old downtown keeps a cluster of historic churches and a waterfront plaza, and the resort area of San Carlos sits just up the coast.
- Templo de San Fernando: The church of San Fernando is one of the historic landmarks of downtown Guaymas. source
- Plaza 13 de Julio: This downtown plaza is one of the public squares highlighted by Mexico's Culture Ministry among Guaymas' points of interest. source
- Templo de San José de Guaymas: The parish church of San José is another stop on a walk through the city's historic churches, along with the Sagrado Corazón church. source
More drives to Guaymas
- Gilbert, AZ to Guaymas
- Goodyear, AZ to Guaymas
- Cottonwood, AZ to Guaymas
- Clarkdale, AZ to Guaymas
- Sierra Vista, AZ to Guaymas
- Tucson, AZ to Guaymas
From Mesa to other places in Mexico
- Mesa, AZ to Nuevo Casas Grandes
- Mesa, AZ to San Felipe
- Mesa, AZ to Tijuana
- Mesa, AZ to Bahía de los Ángeles
- Mesa, AZ to Agua Prieta
- Mesa, AZ to Nogales
All routes to Guaymas, border crossings and permits in one place: Driving to Guaymas, Mexico from the U.S.
Continue Your Adventure
Frequently asked questions
How long is the drive from Mesa to Guaymas?
About 7 h 26 min of driving without stops, over 431 miles.
How far is Guaymas from Mesa by car?
About 431 miles (693 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Where does the Mesa to Guaymas drive cross into Mexico?
At about mile 170 of this route, from Arizona into Sonora, near the Nogales port of entry.
Do I need a permit to drive my car from Mesa to Guaymas?
No vehicle permit is needed. Guaymas is inside Sonora's free zone (west of Highway 15 as far south as Empalme, plus a strip along the border that includes Cananea). Going farther south or east of Highway 15 requires a permit. You also need Mexican auto insurance and a passport book or card. An FMM entry permit is required too.
Is it safe to drive from Mesa to Guaymas?
The U.S. State Department rates Sonora Level 3: Reconsider Travel (advisory issued May 29, 2026). Read the full advisory before you go.
What roads does the drive from Mesa to Guaymas use?
In order: AZ 87, AZ 587, I-10, I-19, MEX-15D and MEX-15. The road-by-road table above shows the route miles and states for each one.
What are good stops between Mesa and Guaymas?
Closest to the road: Arizona Railway Museum (railway museum, mile 12, 0.4 mi from the route); Tubac Presidio State Historic Park (state park, mile 148, 0.4 mi from the route); Tumacácori National Historical Park (National Historical Park, mile 151, 0.2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway mile markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route (roughly 2 to 7 miles depending on the type, farther for World Heritage sites): at least one strong stop for each stretch of the drive, then the best-known places nearest the road, with no more than five of one type, up to nine in all. Places that are closed, private or not open to visitors are removed. Place and city descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on September 29, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.