By road, Mar del Plata and Santa Fe are about 546 miles (878 km) apart, or roughly 9 h 44 min of driving.
Full advisory: Argentina. Advisory issued: Argentina July 10, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers in Argentina tend to be aggressive, especially in Buenos Aires, and often ignore traffic regulations.”
| Distance by road | 546 mi (878 km) |
|---|---|
| Drive time without stops | 9 h 44 min |
| Main roads, in order | RP2 → RN1 → AV1-N → RN9 → RNA008 → AP01 |
| Provinces on the route | Buenos Aires, Ciudad de Buenos Aires, Santa Fe |
| Fuel estimate (car at 25 mpg) | about 21.8 gal; actual use varies by vehicle and traffic |
| Stops listed below | 9 |
How the Mar del Plata to Santa Fe drive plays out
RP2 (234 mi) and RN9 (170 mi) carry about 74% of the 546 miles. It runs through 3 provinces: Buenos Aires, Ciudad de Buenos Aires, Santa Fe. Of the 9 stops listed below, 5 are within a mile of the road.
Roads you'll take from Mar del Plata to Santa Fe
| Road | Route miles (from–to) | Length, mi | Province |
|---|---|---|---|
| local roads | 0–2 | 2 | Buenos Aires |
| RP2 | 2–236 | 234 | Buenos Aires |
| connecting roads | 236–237 | 1 | Buenos Aires |
| RN1 | 237–254 | 17 | Buenos Aires, Ciudad de Buenos Aires |
| local roads | 254–257 | 3 | Ciudad de Buenos Aires |
| AV1-N | 257–263 | 6 | Ciudad de Buenos Aires |
| connecting roads | 263–265 | 2 | Ciudad de Buenos Aires |
| RN9 | 265–435 | 170 | Ciudad de Buenos Aires, Buenos Aires, Santa Fe |
| connecting roads | 435–436 | 1 | Santa Fe |
| RNA008 | 436–446 | 10 | Santa Fe |
| AP01 | 446–544 | 98 | Santa Fe |
| local roads | 544–546 | 2 | Santa Fe |
- Mile 250 of this route: Buenos Aires → Ciudad de Buenos Aires (province line)
- Mile 266 of this route: Ciudad de Buenos Aires → Buenos Aires (province line)
- Mile 405 of this route: Buenos Aires → Santa Fe (province line)
Where to stop on the way to Santa Fe
- Right off the route (under 1 mile): Museo del Cine Pablo Ducrós Hicken (mile 254), AMALITA Collection (mile 256), Galileo Galilei Planetarium (mile 260), Japanese Garden, Belén de Escobar (mile 288), Temaikèn (mile 288)
- Nature and outdoors: Japanese Garden, Belén de Escobar (mile 288), Ciervo de los Pantanos National Park (mile 298), Balneario La Florida (mile 446)
- Museums and history: Museo del Cine Pablo Ducrós Hicken (mile 254), AMALITA Collection (mile 256), Palacio de Aguas Corrientes (mile 257), House of Valentín Alsina (mile 262)
- With kids: Temaikèn (mile 288)
Museo del Cine Pablo Ducrós Hicken
Established in 1971, Museo del Cine Pablo Ducrós Hicken in Buenos Aires traces Argentine cinema through about 90,000 film reels plus photos, posters, scripts, costumes and film equipment.
AMALITA Collection
Officially the Amalia Lacroze de Fortabat Art Collection, the AMALITA Collection is an art museum in Buenos Aires.
Palacio de Aguas Corrientes
Known as the Palace of Running Waters, the Palacio de Aguas Corrientes is an architecturally significant water pumping station in Buenos Aires and former headquarters of Obras Sanitarias de la Nación.
Galileo Galilei Planetarium
The Galileo Galilei Planetarium, known locally simply as Planetario, sits in Parque Tres de Febrero in the Palermo district of Buenos Aires.
House of Valentín Alsina
In Buenos Aires' Belgrano neighborhood, the House of Valentín Alsina dates from 1856 and was declared a National Historic Monument in 1977; it bears the name of the writer and two-time governor.
Japanese Garden, Belén de Escobar
Landscape engineer Yasuo Inomata designed this Japanese garden in Belén de Escobar in 1969, and the local Japanese community donated it to the city. Red, white and spotted koi swim in its 1,000-square-meter pond.
Temaikèn
Temaikèn is a zoo in Belén de Escobar, outside Buenos Aires, and the only zoo in Argentina accredited by the Association of Zoos and Aquariums.
Ciervo de los Pantanos National Park
About 2,500 hectares of wetlands in Campana, Buenos Aires province, are protected as Ciervo de los Pantanos National Park. It's a Ramsar Site and home to the marsh deer and plenty of waterbirds.
Balneario La Florida
Rosario's municipal riverside beach area runs nearly 4 kilometers along the Paraná River, from the Rosario-Victoria Bridge to Parque Alem, and dates to around 1940.
Once you reach Santa Fe
Provincial Historical Museum of Santa Fe Brigadier Estanislao López
The Provincial Historical Museum Brigadier Estanislao López (Museo Histórico Provincial Brig. Gral. Estanislao López) is a history museum in Santa Fe, Argentina.
Rosa Galisteo de Rodríguez Fines Arts Provincial Museum
The Museo Provincial de Bellas Artes Rosa Galisteo de Rodríguez in the city of Santa Fe shows modern and contemporary Argentine art and is run by the provincial government.
Museo Etnográfico y Colonial Juan de Garay
Next to the San Francisco Convent on Plaza de las Tres Culturas in Santa Fe, the Museo Etnográfico y Colonial Juan de Garay covers ethnography and archaeology.
More drives to Santa Fe
From Mar del Plata to other places in Argentina
- Mar del Plata to Viedma
- Mar del Plata to Adrogué
- Mar del Plata to Tigre
- Mar del Plata to San Antonio de Areco
- Mar del Plata to Arrecifes
- Mar del Plata to Pergamino
Continue Your Adventure
Frequently asked questions
How long does it take to drive from Mar del Plata to Santa Fe?
About 9 h 44 min of driving without stops, over 546 miles.
What is the driving distance from Mar del Plata to Santa Fe?
About 546 miles (878 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from Mar del Plata to Santa Fe?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions. Read the full advisory before you go.
Which highways go from Mar del Plata to Santa Fe?
In order: RP2, RN1, AV1-N, RN9, RNA008 and AP01. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from Mar del Plata to Santa Fe?
Closest to the road: Museo del Cine Pablo Ducrós Hicken (film museum, mile 254, 0.2 mi from the route); AMALITA Collection (art museum, mile 256, 0.2 mi from the route); Galileo Galilei Planetarium (planetarium, mile 260, 0.3 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.