The Wayro route from Buenos Aires to Santa Fe is 291 miles (468 km), about 4 h 60 min of driving without stops.
Full advisory: Argentina. Advisory issued: Argentina July 10, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers in Argentina tend to be aggressive, especially in Buenos Aires, and often ignore traffic regulations.”
| Distance by road | 291 mi (468 km) |
|---|---|
| Driving time, no stops | 4 h 60 min |
| Main roads, in order | AV1-N → RN9 → RNA008 → AP01 |
| Provinces on the route | Ciudad de Buenos Aires, Buenos Aires, Santa Fe |
| Fuel estimate (car at 25 mpg) | about 11.6 gal; actual use varies by vehicle and traffic |
| Stops listed below | 8 |
On the road from Buenos Aires to Santa Fe
RN9 (170 mi) and AP01 (98 mi) carry about 92% of the 291 miles. It runs through 3 provinces: Ciudad de Buenos Aires, Buenos Aires, Santa Fe. None of the 8 stops below is right on the road, so plan each as a short side trip.
Buenos Aires to Santa Fe: the road sequence
| Road | Route miles (from–to) | Length, mi | Province |
|---|---|---|---|
| local roads | 0–2 | 2 | Ciudad de Buenos Aires |
| AV1-N | 2–8 | 6 | Ciudad de Buenos Aires |
| connecting roads | 8–10 | 2 | Ciudad de Buenos Aires |
| RN9 | 10–180 | 170 | Ciudad de Buenos Aires, Buenos Aires, Santa Fe |
| connecting roads | 180–181 | 1 | Santa Fe |
| RNA008 | 181–191 | 10 | Santa Fe |
| AP01 | 191–289 | 98 | Santa Fe |
| local roads | 289–291 | 2 | Santa Fe |
- Mile 11 of this route: Ciudad de Buenos Aires → Buenos Aires (province line)
- Mile 150 of this route: Buenos Aires → Santa Fe (province line)
Where to stop on the way to Santa Fe
- Nature and outdoors: Ciervo de los Pantanos National Park (mile 42), Balneario La Florida (mile 191), Campo de la Gloria (mile 201)
- Museums and history: Museo de Arte Español Enrique Larreta (mile 7), Carnacini House Museum (mile 12), Quinta Los Ombúes (mile 14), Museo del Deporte Santafesino (mile 181)
- With kids: Paraná River Aquarium (mile 191)
Museo de Arte Español Enrique Larreta
In Buenos Aires's Belgrano neighborhood, the Enrique Larreta Museum is devoted to Spanish art.
Carnacini House Museum
Painter Ceferino Carnacini lived for fifty years in the house that is now the Carnacini House Museum (Museo Casa Carnacini), a municipal art museum in Villa Ballester, Argentina.
Quinta Los Ombúes
In the historic center of San Isidro, Buenos Aires Province, Quinta Los Ombúes is a museum and historic site set in an old colonial-style country house.
Ciervo de los Pantanos National Park
Marsh deer give their name to Ciervo de los Pantanos National Park, a Ramsar Site in Campana, Buenos Aires province, where waterbirds are abundant.
Museo del Deporte Santafesino
Set inside Parque Héroes de Malvinas on Avenida Ayacucho in Rosario, Museo del Deporte Santafesino is a sports museum just a few blocks from Lionel Messi's childhood home.
Paraná River Aquarium
The Paraná River Aquarium in Rosario is a public aquarium built as a scientific and educational center focused on the river.
Balneario La Florida
Rosario's municipal riverside beach area runs nearly 4 kilometers along the Paraná River, from the Rosario-Victoria Bridge to Parque Alem, and dates to around 1940.
Campo de la Gloria
Campo de la Gloria is a historic park in San Lorenzo, Santa Fe Province, declared a National Historic Monument by law in October 1940.
Arriving in Santa Fe
Museo Etnográfico y Colonial Juan de Garay
Next to the San Francisco Convent on Plaza de las Tres Culturas in Santa Fe, the Museo Etnográfico y Colonial Juan de Garay covers ethnography and archaeology.
Provincial Historical Museum of Santa Fe Brigadier Estanislao López
The Provincial Historical Museum Brigadier Estanislao López (Museo Histórico Provincial Brig. Gral. Estanislao López) is a history museum in Santa Fe, Argentina.
Rosa Galisteo de Rodríguez Fines Arts Provincial Museum
The Museo Provincial de Bellas Artes Rosa Galisteo de Rodríguez in the city of Santa Fe shows modern and contemporary Argentine art and is run by the provincial government.
More drives to Santa Fe
From Buenos Aires to other places in Argentina
- Buenos Aires to Magdalena
- Buenos Aires to Ayacucho, Argentina
- Buenos Aires to Sierra de La Ventana
- Buenos Aires to Luján
- Buenos Aires to San Antonio de Areco
- Buenos Aires to Arrecifes
Continue Your Adventure
Frequently asked questions
How long does it take to drive from Buenos Aires to Santa Fe?
About 4 h 60 min of driving without stops, over 291 miles.
What is the driving distance from Buenos Aires to Santa Fe?
About 291 miles (468 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from Buenos Aires to Santa Fe?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions. Read the full advisory before you go.
Which highways go from Buenos Aires to Santa Fe?
In order: AV1-N, RN9, RNA008 and AP01. The road-by-road table above shows the route miles for each one.
What are good stops between Buenos Aires and Santa Fe?
Closest to the road: Museo de Arte Español Enrique Larreta (art museum, mile 7, 1 mi from the route); Balneario La Florida (beach, mile 191, 1 mi from the route); Campo de la Gloria (park, mile 201, 2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.