The Wayro route from Manizales to Sincelejo is 425 miles (684 km), about 10 h 24 min of driving without stops.
Read the full advisory before you go: Colombia. Advisory issued: Colombia March 31, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Colombia: “Highways may not have lights or signs showing destinations.”
| Total distance | 425 mi (684 km) |
|---|---|
| Drive time without stops | 10 h 24 min |
| Main roads, in order | 25BAN |
| Departments on the route | Caldas, Antioquia, Córdoba, Sucre |
| Fuel estimate (car at 25 mpg) | about 17.0 gal; actual use varies by vehicle and traffic |
| Stops listed below | 7 |
The Manizales–Sincelejo drive in a few lines
25BAN (20 mi) carries about 5% of the 425 miles. It runs through 4 departments: Caldas, Antioquia, Córdoba, Sucre. Of the 7 stops listed below, 5 are within a mile of the road.
The route from Manizales to Sincelejo, road by road
| Road | Route miles (from–to) | Length, mi | Department |
|---|---|---|---|
| local roads | 0–91 | 91 | Caldas, Antioquia |
| 25BAN | 91–111 | 20 | Antioquia |
| local roads | 111–125 | 14 | Antioquia |
| connecting roads | 125–126 | 1 | Antioquia |
| local roads | 126–144 | 18 | Antioquia |
| connecting roads | 144–145 | 1 | Antioquia |
| local roads | 145–425 | 280 | Antioquia, Córdoba, Sucre |
- Mile 69 of this route: Caldas → Antioquia (department line)
- Mile 314 of this route: Antioquia → Córdoba (department line)
- Mile 410 of this route: Córdoba → Sucre (department line)
Breaking up the drive: stops between Manizales and Sincelejo
- Right off the route (under 1 mile): El Castillo Museum (mile 130), Teatro al aire libre Carlos Vieco (mile 133), Our Lady of the Rosary Cathedral, Girardota (mile 149), Our Lady of the Rosary of Chiquinquirá Cathedral (mile 181), Basilica of Our Lady of Mercy (mile 211)
- Nature and outdoors: Salto Chorrolato (mile 139)
- Museums and history: El Castillo Museum (mile 130), Museo Etnográfico Miguel Ángel Builes (mile 134), Our Lady of the Rosary Cathedral, Girardota (mile 149), Our Lady of the Rosary of Chiquinquirá Cathedral (mile 181), Basilica of Our Lady of Mercy (mile 211)
El Castillo Museum
In Medellín's El Poblado district, El Castillo Museum displays porcelain and glass, stained glass, antiques, paintings and sculptures in its permanent exhibitions.
Teatro al aire libre Carlos Vieco
On the north slope of Cerro Nutibara in Medellín, this Greek-inspired open-air theater opened in 1984 and honors Antioquian composer Carlos Vieco Ortiz.
Museo Etnográfico Miguel Ángel Builes
Founded in 1962 by the Yarumal Missionaries, this ethnographic museum in Medellín's Ferrini neighborhood focuses on the culture and daily life of Colombia's Indigenous peoples.
Salto Chorrolato
In the San Félix area of Bello, in the Aburrá Valley near Medellín, Salto Chorrolato (Chorro del Hato) is a multi-step waterfall and a symbol of the municipality.
Our Lady of the Rosary Cathedral, Girardota
Girardota Cathedral is a Neo-Romanesque church of exposed brick, designed by French architect Charles Émile Carré and built over 32 years.
Our Lady of the Rosary of Chiquinquirá Cathedral
Facing the south side of Bolívar Park in Santa Rosa de Osos, Colombia, this cathedral is dedicated to the Virgin Mary as Our Lady of the Rosary of Chiquinquirá.
Basilica of Our Lady of Mercy
A minor basilica in Yarumal, the Basilica of Our Lady of Mercy belongs to the Diocese of Santa Rosa de Osos and serves as the parish church.
In Sincelejo itself
St. Francis of Assisi Cathedral, Sincelejo
Sincelejo Cathedral, dedicated to St. Francis of Assisi, is a cathedral church of the Catholic Church in Sincelejo, Colombia.
More drives to Sincelejo
From Manizales to other places in Colombia
- Manizales to Guatapé
- Manizales to Girardot City
- Manizales to Tuluá
- Manizales to Zipaquirá
- Manizales to Tunja
- Manizales to Sogamoso
Frequently asked questions
How long is the drive from Manizales to Sincelejo?
About 10 h 24 min of driving without stops, over 425 miles.
How far is Sincelejo from Manizales by car?
About 425 miles (684 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the Manizales to Sincelejo drive?
The U.S. State Department rates Colombia Level 3: Reconsider Travel. Read the full advisory before you go.
Where can you stop on the way from Manizales to Sincelejo?
Closest to the road: Teatro al aire libre Carlos Vieco (theater, mile 133, 0.2 mi from the route); Our Lady of the Rosary of Chiquinquirá Cathedral (cathedral, mile 181, 0.4 mi from the route); Basilica of Our Lady of Mercy (basilica, mile 211, 0.6 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.