The Wayro route from La Plata to Paysandú, Uruguay is 245 miles (394 km), about 4 h 42 min of driving without stops. You cross from Argentina into Uruguay at about mile 239, at the Colón–Paysandú bridge.
Full advisory: Argentina, Uruguay. Advisory issued: Argentina July 10, 2026; Uruguay July 28, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers in Argentina tend to be aggressive, especially in Buenos Aires, and often ignore traffic regulations.”
- Uruguay: “Several of the main highways are particularly accident-ridden.”
| Distance by road | 245 mi (394 km) |
|---|---|
| Drive time without stops | 4 h 42 min |
| Main roads, in order | RN1 → AV1-N → RN9 → RP6 → RN12 → RN14 → RN135 |
| Border crossing | about mile 239, Argentina → Uruguay (the Colón–Paysandú bridge) |
| Regions on the route | Buenos Aires, Ciudad de Buenos Aires, Entre Ríos, Paysandú |
| Fuel estimate (car at 25 mpg) | about 9.8 gal; actual use varies by vehicle and traffic |
| Stops listed below | 7 |
Crossing from Argentina into Uruguay
The route crosses at about mile 239, at the Colón–Paysandú bridge, from Entre Ríos into Paysandú. Plan on two checks on each side: immigration for your passport and customs for the car.
| Entering Uruguay (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. |
|---|---|
| Driving in Uruguay | You can drive on your U.S. license. |
| Entering Argentina (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid when you enter; leave a blank page for the entry and exit stamps. |
| Driving in Argentina | A valid U.S. license usually works; an International Driving Permit is recommended. |
| Rental car | Cross only if the rental company authorizes it in writing and gives you the papers for the border; ask before you book. |
Sources: U.S. State Department, Uruguay (updated August 13, 2026); U.S. State Department, Argentina (updated July 16, 2026). Checked October 10, 2026; rules change, so confirm before you go.
How the La Plata to Paysandú drive plays out
RN14 (94 mi) and RN12 (47 mi) carry about 58% of the 245 miles. The first 239 miles are in Argentina; the last 6 are in Uruguay. It runs through 4 regions: Buenos Aires, Ciudad de Buenos Aires, Entre Ríos, Paysandú. Of the 7 stops listed below, 3 are within a mile of the road.
The route from La Plata to Paysandú, road by road
| Road | Route miles (from–to) | Length, mi | Region |
|---|---|---|---|
| local roads | 0–3 | 3 | Buenos Aires |
| RN1 | 3–33 | 30 | Buenos Aires, Ciudad de Buenos Aires |
| local roads | 33–37 | 4 | Ciudad de Buenos Aires |
| AV1-N | 37–42 | 5 | Ciudad de Buenos Aires |
| connecting roads | 42–45 | 3 | Ciudad de Buenos Aires |
| RN9 | 45–84 | 39 | Buenos Aires |
| connecting roads | 84–85 | 1 | Buenos Aires |
| RP6 | 85–89 | 4 | Buenos Aires |
| RN12 | 89–136 | 47 | Buenos Aires, Entre Ríos |
| RN14 | 136–230 | 94 | Entre Ríos |
| RN135 | 230–238 | 8 | Entre Ríos |
| local roads | 238–245 | 7 | Entre Ríos, Paysandú |
- Mile 29 of this route: Buenos Aires → Ciudad de Buenos Aires (region line)
- Mile 45 of this route: Ciudad de Buenos Aires → Buenos Aires (region line)
- Mile 107 of this route: Buenos Aires → Entre Ríos (region line)
- Mile 239 of this route: Entre Ríos → Paysandú (international border)
Where to stop on the way to Paysandú
- Right off the route (under 1 mile): Buenos Aires Museum of Modern Art (mile 34), Parque de la Memoria (mile 41), Japanese Garden, Belén de Escobar (mile 68)
- Nature and outdoors: Parque de la Memoria (mile 41), Parque Natural Municipal Ribera Norte (mile 48), Japanese Garden, Belén de Escobar (mile 68)
- Museums and history: Buenos Aires Museum of Modern Art (mile 34), Ricardo Rojas' House Museum - Research Institute (mile 37), Sarmiento Historical Museum (mile 41), San Isidro Cathedral (mile 48)
Buenos Aires Museum of Modern Art
Known locally as the Museo de Arte Moderno de Buenos Aires, this modern art museum is in the San Telmo district of Buenos Aires.
Ricardo Rojas' House Museum - Research Institute
Ricardo Rojas had this Buenos Aires house built in 1927 by architect Ángel Guido; today it operates as a house museum.
Sarmiento Historical Museum
In the Belgrano neighborhood of Buenos Aires, the Sarmiento Historical Museum covers the Generation of '80 and the life of President Domingo Faustino Sarmiento, with sections on Nicolás Avellaneda and the 1880 federalization.
Parque de la Memoria
Facing the Río de la Plata at the northern end of Buenos Aires' Belgrano section, Parque de la Memoria is a public memorial to the victims of Argentina's 1976–1983 military regime.
Parque Natural Municipal Ribera Norte
On the Río de la Plata shore in Acassuso, San Isidro, Ribera Norte is a municipal nature park protecting green space within greater Buenos Aires.
San Isidro Cathedral
Main church of the Diocese of San Isidro, this cathedral stands on Del Libertador Avenue opposite Plaza Mitre, in the historic quarter of San Isidro in Buenos Aires province.
Japanese Garden, Belén de Escobar
Landscape engineer Yasuo Inomata designed this Japanese garden in Belén de Escobar in 1969, and the local Japanese community donated it to the city. Red, white and spotted koi swim in its 1,000-square-meter pond.
Arriving in Paysandú
Nuestra Señora del Rosario y San Benito de Palermo, Paysandú
Paysandú's Catholic parish church of Our Lady of the Rosary and St. Benedict of Palermo was named a minor basilica in 1949 and remains an active parish of the city.
Teatro Florencio Sánchez
In the city of Paysandú, Teatro Florencio Sánchez is a theater and movie house that has been declared a national historic monument of Uruguay.
More drives to Paysandú
- Rivera to Paysandú
- Montevideo to Paysandú
- Buenos Aires to Paysandú, Uruguay
- Mar del Plata to Paysandú, Uruguay
- Berisso to Paysandú, Uruguay
- Porto Alegre to Paysandú, Uruguay
More drives from La Plata
- La Plata to Tigre
- La Plata to Luján
- La Plata to San Antonio de Areco
- La Plata to Arrecifes
- La Plata to Pergamino
- La Plata to Martínez
Continue Your Adventure
Frequently asked questions
How long does it take to drive from La Plata to Paysandú, Uruguay?
About 4 h 42 min of driving without stops, over 245 miles.
How far is Paysandú, Uruguay from La Plata by car?
About 245 miles (394 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Where does the La Plata to Paysandú drive cross the border?
At about mile 239, from Argentina into Uruguay, at the Colón–Paysandú bridge.
What do U.S. citizens need to drive from La Plata into Uruguay?
No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. You can drive on your U.S. license. (U.S. State Department, updated August 13, 2026.)
What does the U.S. travel advisory say about the La Plata to Paysandú drive?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions; Uruguay Level 2: Exercise Increased Caution. Read the full advisory before you go.
What roads does the drive from La Plata to Paysandú use?
In order: RN1, AV1-N, RN9, RP6, RN12, RN14 and RN135. The road-by-road table above shows the route miles for each one.
What are good stops between La Plata and Paysandú?
Closest to the road: Buenos Aires Museum of Modern Art (museum of modern art, mile 34, 0.4 mi from the route); Parque de la Memoria (memorial park, mile 41, 0.4 mi from the route); Japanese Garden, Belén de Escobar (japanese garden, mile 68, 0.2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.