The Wayro route from Itajaí to São Carlos is 505 miles (813 km), about 10 h 37 min of driving without stops.
- Level 4: Do Not Travel in Brazil: informal housing developments (favelas, vilas, comunidades or conglomerados).
Full advisory: Brazil. Advisory issued: Brazil August 31, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Brazil: “Flooding makes some roads through the Amazon impassable for much of the year.”
| Total distance | 505 mi (813 km) |
|---|---|
| Time at the wheel, no stops | 10 h 37 min |
| Main roads, in order | BR-101 → BR-376 → BR-116 → SP-021 → SP-348 → SPA-102/330 → SP-330 → SP-310 |
| States on the route | Santa Catarina, Paraná, São Paulo |
| Fuel estimate (car at 25 mpg) | about 20.2 gal; actual use varies by vehicle and traffic |
| Stops listed below | 9 |
What the drive from Itajaí to São Carlos is like
BR-116 (236 mi) and BR-101 (74 mi) carry about 61% of the 505 miles. It runs through 3 states: Santa Catarina, Paraná, São Paulo. Of the 9 stops listed below, 1 are within a mile of the road.
Which roads connect Itajaí and São Carlos
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–4 | 4 | Santa Catarina |
| BR-101 | 4–78 | 74 | Santa Catarina |
| BR-376 | 78–121 | 43 | Santa Catarina, Paraná |
| BR-116 | 121–357 | 236 | Paraná, São Paulo |
| connecting roads | 357–358 | 1 | São Paulo |
| SP-021 | 358–373 | 15 | São Paulo |
| connecting roads | 373–375 | 2 | São Paulo |
| SP-348 | 375–418 | 43 | São Paulo |
| SPA-102/330 | 418–423 | 5 | São Paulo |
| SP-330 | 423–455 | 32 | São Paulo |
| SP-310 | 455–502 | 47 | São Paulo |
| local roads | 502–505 | 3 | São Paulo |
- Mile 79 of this route: Santa Catarina → Paraná (state line)
- Mile 185 of this route: Paraná → São Paulo (state line)
Stops between Itajaí and São Carlos
- Right off the route (under 1 mile): Museu do Índio (mile 355)
- Nature and outdoors: Guaricana National Park (mile 90), Graciosa State Park (mile 148), Rio Turvo State Park (mile 211), Campina do Encantado State Park (mile 249)
- Museums and history: Museu da Bicicleta de Joinville (mile 52), Joinville Art Museum (mile 53), Museu do Índio (mile 355), Museu de Minerais e Rochas Heinz Ebert (mile 469)
Museu da Bicicleta de Joinville
Founded in 2000 and run by the city's cultural foundation, Joinville's bicycle museum holds more than 16,000 items, including bicycles, parts, posters, photos, unusual bikes and a model built to ride on rail tracks.
Joinville Art Museum
Opened on September 3, 1976, the Museu de Arte de Joinville documents, studies and conserves artworks, mainly by local artists. It is run by the Joinville Cultural Foundation and sits on Rua XV de Novembro.
Guaricana National Park
Within the largest continuous stretch of dense Atlantic Forest in Brazil, Guaricana National Park protects part of the Serra do Mar in Paraná.
Graciosa State Park
Created by state decree in 1990 near Morretes, Paraná, Graciosa State Park protects dense Atlantic Forest, with a mandate to preserve the area's water regime, plants and wildlife.
Rio Turvo State Park
Rio Turvo State Park protects Atlantic Forest across Cajati, Barra do Turvo and Jacupiranga. Besides its trails, it holds the Cachoeira do Azeite waterfall, the Gruta da Capelinha cave and Morro do Guaraú.
Campina do Encantado State Park
Campina do Encantado State Park, in the São Paulo state town of Pariquera-Açu, protects a peat bog and a patch of wetland forest, described as a unique ecosystem of great scientific interest.
Museu do Índio
In Embu das Artes, São Paulo, this private museum linked to an Indigenous culture information center displays over 500 ethnographic pieces and runs cultural programs about Brazil's Indigenous peoples.
Mosteiro de São Bento
Jundiaí's Monastery of Saint Benedict was founded on June 2, 1667, and was originally called Hospício do Patriarca São Bento.
Museu de Minerais e Rochas Heinz Ebert
On the Unesp university campus in Rio Claro, the Museu de Minerais e Rochas Heinz Ebert occupies the building of the Department of Petrology and Metallogeny at the Institute of Geosciences and Exact Sciences.
When you get to São Carlos
Memorial Casa Ronald Golias
Opened in March 2016 in São Carlos, this memorial preserves the legacy of Ronald Golias, the nationally known comedian born in the city on May 4, 1929.
São Carlos Municipal Theatre
Officially named Teatro Municipal Dr. Alderico Vieira Perdigão, the São Carlos Municipal Theatre is the city's public theater in São Carlos, in the interior of São Paulo state.
Museum of Science Professor Mario Tolentino
Opened by the city of São Carlos in 2012, this science museum offers interactive exhibits and experiments in science, technology and art, named for professor and historian Mario Tolentino.
More drives to São Carlos
- Jundiaí to São Carlos
- São Paulo to São Carlos
- São Vicente to São Carlos
- Santos to São Carlos
- Mogi das Cruzes to São Carlos
- Taubaté to São Carlos
From Itajaí to other places in Brazil
- Itajaí to Paranaguá
- Itajaí to Guarapuava
- Itajaí to Passo Fundo
- Itajaí to São Leopoldo
- Itajaí to Itanhaém
- Itajaí to Novo Hamburgo
Frequently asked questions
How long does it take to drive from Itajaí to São Carlos?
About 10 h 37 min of driving without stops, over 505 miles.
How far is São Carlos from Itajaí by car?
About 505 miles (813 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the Itajaí to São Carlos drive?
The U.S. State Department rates Brazil Level 2: Exercise Increased Caution. Read the full advisory before you go.
What roads does the drive from Itajaí to São Carlos use?
In order: BR-101, BR-376, BR-116, SP-021, SP-348, SPA-102/330, SP-330 and SP-310. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from Itajaí to São Carlos?
Closest to the road: Museu da Bicicleta de Joinville (museum, mile 52, 1 mi from the route); Joinville Art Museum (art museum, mile 53, 2 mi from the route); Museu do Índio (museum, mile 355, 0.4 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.