The Wayro route from Guanajuato to Tuxtepec is 481 miles (774 km), about 8 h 25 min of driving without stops.
| Distance | 481 mi (774 km) |
|---|---|
| Driving time, no stops | 8 h 25 min |
| Main roads, in order | MEX-110 → MEX-45 → MEX-45D → MEX-47D → MEX-57D → MEX-M40D → MEX-150D → MEX-145 → MEX-175 |
| Mexican states on the route | Guanajuato (Level 3), Querétaro (Level 2), State of Mexico (Level 2), Hidalgo (Level 2), Tlaxcala (Level 2), Puebla (Level 2), Veracruz (Level 2), Oaxaca (Level 2) |
| Toll roads | MEX-45D, MEX-43D, MEX-47D, MEX-57D, MEX-M40D, MEX-150D |
| Fuel estimate (car at 25 mpg) | about 19.2 gal; actual use varies by vehicle and traffic |
| Stops listed below | 7 |
Driving this route in a car with U.S. plates
| Temporary vehicle import permit (TIP) | Required: this route is outside the zones where U.S.-registered cars can skip the temporary import permit (Baja California, Baja California Sur and part of Sonora) |
|---|---|
| Mexican auto insurance | Required for all vehicles: buy a Mexican policy before you drive |
Sources: U.S. State Department, Mexico travel information (updated August 11, 2026); permits are issued by Banjercito.
What the drive from Guanajuato to Tuxtepec is like
MEX-150D (152 mi) and MEX-M40D (106 mi) carry about 54% of the 481 miles. MEX-45D, MEX-47D, MEX-57D, MEX-M40D, MEX-150D are toll highways (cuota); MEX-110, MEX-45, MEX-145, MEX-175 are free federal roads (libre). It runs through 8 states: Guanajuato, Querétaro, State of Mexico, Hidalgo, Tlaxcala, Puebla, Veracruz, Oaxaca. Of the 7 stops listed below, 2 are within a mile of the road.
The route from Guanajuato to Tuxtepec, road by road
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–1 | 1 | Guanajuato |
| MEX-110 | 1–7 | 6 | Guanajuato |
| local roads | 7–13 | 6 | Guanajuato |
| MEX-45 | 13–23 | 10 | Guanajuato |
| connecting roads | 23–24 | 1 | Guanajuato |
| MEX-45D | 24–75 | 51 | Guanajuato |
| connecting roads | 75–76 | 1 | Guanajuato |
| MEX-47D | 76–128 | 52 | Guanajuato, Querétaro |
| MEX-57D | 128–163 | 35 | Querétaro, State of Mexico |
| connecting roads | 163–164 | 1 | Hidalgo |
| MEX-M40D | 164–270 | 106 | Hidalgo, State of Mexico, Tlaxcala, Puebla |
| connecting roads | 270–271 | 1 | Puebla |
| MEX-150D | 271–423 | 152 | Puebla, Veracruz |
| connecting roads | 423–425 | 2 | Veracruz |
| MEX-145 | 425–473 | 48 | Veracruz |
| MEX-175 | 473–481 | 8 | Veracruz, Oaxaca |
- Mile 88 of this route: Guanajuato → Querétaro (state line)
- Mile 130 of this route: Querétaro → State of Mexico (state line)
- Mile 163 of this route: State of Mexico → Hidalgo (state line)
- Mile 193 of this route: Hidalgo → State of Mexico (state line)
- Mile 207 of this route: State of Mexico → Hidalgo (state line)
- Mile 224 of this route: Hidalgo → State of Mexico (state line)
- Mile 236 of this route: State of Mexico → Hidalgo (state line)
- Mile 244 of this route: Hidalgo → Tlaxcala (state line)
- Mile 267 of this route: Tlaxcala → Puebla (state line)
- Mile 355 of this route: Puebla → Veracruz (state line)
- Mile 477 of this route: Veracruz → Oaxaca (state line)
Stops between Guanajuato and Tuxtepec
- Right off the route (under 1 mile): Tula National Park (mile 176), Cañón del Río Blanco National Park (mile 367)
- Nature and outdoors: El Cimatario National Park (mile 93), Tula National Park (mile 176), Cañón del Río Blanco National Park (mile 367)
- Museums and history: Museo Regional de la Revolución Mexicana (mile 291), Orizaba Cathedral (mile 376)
El Cimatario National Park
El Cimatario National Park protects about 24 square kilometers of land just south of the city of Santiago de Querétaro.
Tula National Park
This park protects the ruins of Tula, ancient capital of the Toltecs. Walk up to the main pyramid to stand beside the Atlantes, basalt warrior figures more than four meters tall, and look for the Coatepantli wall's reliefs of snakes devouring skeletons.
Aqueduct of Padre Tembleque
Built by Franciscan friar Francisco de Tembleque between 1554 and 1572, this 16th-century water system runs more than 48 km between Zempoala and Otumba. Its tallest arcade at Tepeyahualco reaches almost 40 meters, and UNESCO listed it in 2015.
Museo Regional de la Revolución Mexicana
The Serdán family home in downtown Puebla, now the Museo Regional de la Revolución Mexicana, recalls Aquiles, Máximo and Carmen Serdán and the start of the 1910 Revolution. It opened in 1960.
Cañón del Río Blanco National Park
Cañón del Río Blanco National Park is a protected natural area in the Mexican state of Veracruz, set aside by the government as a national park.
Orizaba Cathedral
The Cathedral of St. Michael the Archangel is the main Catholic church of Orizaba, in the state of Veracruz, and the seat of the Diocese of Orizaba.
Teatro Pedro Díaz
In downtown Córdoba, the Teatro Pedro Díaz was built in the late 19th century by Pedro Díaz to a design by engineer A. Durán; its facade was remodeled in 1905.
More drives to Tuxtepec
- Cholula to Tuxtepec
- Mexico City to Tuxtepec
- Pachuca to Tuxtepec
- Toluca to Tuxtepec
- San Juan del Río to Tuxtepec
- Querétaro to Tuxtepec
From Guanajuato to other places in Mexico
- Guanajuato to Amatitán
- Guanajuato to Tequila
- Guanajuato to Jerez, Zacatecas
- Guanajuato to Sombrerete
- Guanajuato to El Rosario, Sinaloa
- Guanajuato to San Ignacio, Sinaloa
Continue Your Adventure
Frequently asked questions
How long is the drive from Guanajuato to Tuxtepec?
About 8 h 25 min of driving without stops, over 481 miles.
How far is Tuxtepec from Guanajuato by car?
About 481 miles (774 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Do I need a permit to drive my U.S. car from Guanajuato to Tuxtepec?
Yes. A temporary vehicle import permit (TIP) is required for a U.S.-registered car on this route, which is outside the zones where it can be skipped. Mexican auto insurance is required for every vehicle.
Is it safe to drive from Guanajuato to Tuxtepec?
The U.S. State Department rates Guanajuato Level 3: Reconsider Travel; Querétaro Level 2: Exercise Increased Caution; State of Mexico Level 2: Exercise Increased Caution; Hidalgo Level 2: Exercise Increased Caution; Tlaxcala Level 2: Exercise Increased Caution; Puebla Level 2: Exercise Increased Caution; Veracruz Level 2: Exercise Increased Caution; Oaxaca Level 2: Exercise Increased Caution (advisory issued May 29, 2026). Read the full advisory before you go.
What roads does the drive from Guanajuato to Tuxtepec use?
In order: MEX-110, MEX-45, MEX-45D, MEX-47D, MEX-57D, MEX-M40D, MEX-150D, MEX-145 and MEX-175. The road-by-road table above shows the route miles and states for each one.
What are good stops between Guanajuato and Tuxtepec?
Closest to the road: Tula National Park (National Park of Mexico, mile 176, 1 mi from the route); Cañón del Río Blanco National Park (National Park of Mexico, mile 367, 0.4 mi from the route); Orizaba Cathedral (cathedral, mile 376, 1 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway mile markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route (roughly 2 to 7 miles depending on the type, farther for World Heritage sites): at least one strong stop for each stretch of the drive, then the best-known places nearest the road, with no more than five of one type, up to nine in all. Places that are closed, private or not open to visitors are removed. Place and city descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on September 29, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.