The Wayro route from Guanajuato to Orizaba is 377 miles (606 km), about 6 h 10 min of driving without stops.
| Distance | 377 mi (606 km) |
|---|---|
| Driving time, no stops | 6 h 10 min |
| Main roads, in order | MEX-110 → MEX-45 → MEX-45D → MEX-47D → MEX-57D → MEX-M40D → MEX-150D |
| Mexican states on the route | Guanajuato (Level 3), Querétaro (Level 2), State of Mexico (Level 2), Hidalgo (Level 2), Tlaxcala (Level 2), Puebla (Level 2), Veracruz (Level 2) |
| Toll roads | MEX-45D, MEX-43D, MEX-47D, MEX-57D, MEX-M40D, MEX-150D |
| Fuel estimate (car at 25 mpg) | about 15.1 gal; actual use varies by vehicle and traffic |
| Stops listed below | 8 |
Driving this route in a car with U.S. plates
| Temporary vehicle import permit (TIP) | Required: this route is outside the zones where U.S.-registered cars can skip the temporary import permit (Baja California, Baja California Sur and part of Sonora) |
|---|---|
| Mexican auto insurance | Required for all vehicles: buy a Mexican policy before you drive |
Sources: U.S. State Department, Mexico travel information (updated August 11, 2026); permits are issued by Banjercito.
What the drive from Guanajuato to Orizaba is like
MEX-M40D (106 mi) and MEX-150D (103 mi) carry about 55% of the 377 miles. MEX-45D, MEX-47D, MEX-57D, MEX-M40D, MEX-150D are toll highways (cuota); MEX-110, MEX-45 are free federal roads (libre). It runs through 7 states: Guanajuato, Querétaro, State of Mexico, Hidalgo, Tlaxcala, Puebla, Veracruz. Of the 8 stops listed below, 2 are within a mile of the road.
The route from Guanajuato to Orizaba, road by road
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–1 | 1 | Guanajuato |
| MEX-110 | 1–7 | 6 | Guanajuato |
| local roads | 7–13 | 6 | Guanajuato |
| MEX-45 | 13–23 | 10 | Guanajuato |
| connecting roads | 23–24 | 1 | Guanajuato |
| MEX-45D | 24–75 | 51 | Guanajuato |
| connecting roads | 75–76 | 1 | Guanajuato |
| MEX-47D | 76–128 | 52 | Guanajuato, Querétaro |
| MEX-57D | 128–163 | 35 | Querétaro, State of Mexico |
| connecting roads | 163–164 | 1 | Hidalgo |
| MEX-M40D | 164–270 | 106 | Hidalgo, State of Mexico, Tlaxcala, Puebla |
| connecting roads | 270–271 | 1 | Puebla |
| MEX-150D | 271–374 | 103 | Puebla, Veracruz |
| local roads | 374–377 | 3 | Veracruz |
- Mile 88 of this route: Guanajuato → Querétaro (state line)
- Mile 130 of this route: Querétaro → State of Mexico (state line)
- Mile 163 of this route: State of Mexico → Hidalgo (state line)
- Mile 193 of this route: Hidalgo → State of Mexico (state line)
- Mile 207 of this route: State of Mexico → Hidalgo (state line)
- Mile 224 of this route: Hidalgo → State of Mexico (state line)
- Mile 236 of this route: State of Mexico → Hidalgo (state line)
- Mile 244 of this route: Hidalgo → Tlaxcala (state line)
- Mile 267 of this route: Tlaxcala → Puebla (state line)
- Mile 355 of this route: Puebla → Veracruz (state line)
Stops between Guanajuato and Orizaba
- Right off the route (under 1 mile): Tula National Park (mile 176), Cañón del Río Blanco National Park (mile 367)
- Nature and outdoors: El Cimatario National Park (mile 93), Tula National Park (mile 176), La Malinche National Park (mile 298), Cañón del Río Blanco National Park (mile 367)
- Museums and history: Celaya Cathedral (mile 63), Xochitecatl (mile 275), Casa del Alfeñique (mile 291)
Celaya Cathedral
Celaya's main Catholic church, the Immaculate Conception Cathedral, occupies the space of a former chapel that was annexed to the neighboring Temple of St. Francis.
El Cimatario National Park
El Cimatario National Park protects about 24 square kilometers of land just south of the city of Santiago de Querétaro.
Tula National Park
This park protects the ruins of Tula, ancient capital of the Toltecs. Walk up to the main pyramid to stand beside the Atlantes, basalt warrior figures more than four meters tall, and look for the Coatepantli wall's reliefs of snakes devouring skeletons.
Church and former convent of Todos los Santos
Franciscan friars built this fortress-style convent in Zempoala, and the complex still keeps the classic layout of atrium, church, open chapel and cloister. It pairs well with a drive through the area's old pulque haciendas.
Xochitecatl
Xochitécatl is a pre-Hispanic archaeological site in the state of Tlaxcala. INAH runs it together with nearby Cacaxtla as a single zone, and the Xochitécatl site museum displays finds from the area.
Casa del Alfeñique
Founded in 1926, the Museo Regional Casa de Alfeñique is a museum in the city of Puebla, housed in the building known as the Casa de Alfeñique.
La Malinche National Park
Tlaxcala's La Malinche National Park surrounds the inactive Matlalcuéyetl volcano, with pine, oak and fir forests on its slopes, hiking trails, birdwatching, and stone cabins and campsites at the Malintzi Vacation Center.
Cañón del Río Blanco National Park
Cañón del Río Blanco National Park is a protected natural area in the Mexican state of Veracruz, set aside by the government as a national park.
When you get to Orizaba
Orizaba Cathedral
The Cathedral of St. Michael the Archangel is the main Catholic church of Orizaba, in the state of Veracruz, and the seat of the Diocese of Orizaba.
Veracruz State Art Museum
Housed in Orizaba's 18th-century former Oratorio of San Felipe Neri, later a hospital and then a jail, the Veracruz State Art Museum (Museo de Arte del Estado) holds more than 700 works, including 36 by Diego Rivera.
Teatro Llave
In central Orizaba, the Gran Teatro Ignacio de la Llave hosts artistic and cultural performances, and its exhibition room shows temporary collections, mostly by artists from the surrounding valley.
More drives to Orizaba
- Cholula to Orizaba
- Mexico City to Orizaba
- Pachuca to Orizaba
- Cuernavaca to Orizaba
- Toluca to Orizaba
- Papantla to Orizaba
From Guanajuato to other places in Mexico
- Guanajuato to Amatitán
- Guanajuato to Tequila
- Guanajuato to Jerez, Zacatecas
- Guanajuato to Sombrerete
- Guanajuato to El Rosario, Sinaloa
- Guanajuato to San Ignacio, Sinaloa
Continue Your Adventure
Frequently asked questions
How long is the drive from Guanajuato to Orizaba?
About 6 h 10 min of driving without stops, over 377 miles.
How far is Orizaba from Guanajuato by car?
About 377 miles (606 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Do I need a permit to drive my U.S. car from Guanajuato to Orizaba?
Yes. A temporary vehicle import permit (TIP) is required for a U.S.-registered car on this route, which is outside the zones where it can be skipped. Mexican auto insurance is required for every vehicle.
Is it safe to drive from Guanajuato to Orizaba?
The U.S. State Department rates Guanajuato Level 3: Reconsider Travel; Querétaro Level 2: Exercise Increased Caution; State of Mexico Level 2: Exercise Increased Caution; Hidalgo Level 2: Exercise Increased Caution; Tlaxcala Level 2: Exercise Increased Caution; Puebla Level 2: Exercise Increased Caution; Veracruz Level 2: Exercise Increased Caution (advisory issued May 29, 2026). Read the full advisory before you go.
What roads does the drive from Guanajuato to Orizaba use?
In order: MEX-110, MEX-45, MEX-45D, MEX-47D, MEX-57D, MEX-M40D and MEX-150D. The road-by-road table above shows the route miles and states for each one.
What are good stops between Guanajuato and Orizaba?
Closest to the road: Tula National Park (National Park of Mexico, mile 176, 1 mi from the route); Xochitecatl (archaeological site, mile 275, 2 mi from the route); Cañón del Río Blanco National Park (National Park of Mexico, mile 367, 0.4 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway mile markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route (roughly 2 to 7 miles depending on the type, farther for World Heritage sites): at least one strong stop for each stretch of the drive, then the best-known places nearest the road, with no more than five of one type, up to nine in all. Places that are closed, private or not open to visitors are removed. Place and city descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on September 29, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.