The Wayro route from Guadalupe, Zacatecas to Apizaco is 432 miles (696 km), about 7 h 17 min of driving without stops.
| Distance | 432 mi (696 km) |
|---|---|
| Driving time, no stops | 7 h 17 min |
| Main roads, in order | MEX-45D → MEX-45 → MEX-47D → MEX-57D → MEX-M40D → MEX-136 |
| Mexican states on the route | Zacatecas (Level 4), Aguascalientes (Level 2), Jalisco (Level 3), Guanajuato (Level 3), Querétaro (Level 2), State of Mexico (Level 2), Hidalgo (Level 2), Tlaxcala (Level 2) |
| Toll roads | MEX-45D, MEX-43D, MEX-47D, MEX-57D, MEX-M40D |
| Fuel estimate (car at 25 mpg) | about 17.3 gal; actual use varies by vehicle and traffic |
| Stops listed below | 8 |
Driving this route in a car with U.S. plates
| Temporary vehicle import permit (TIP) | Required: this route is outside the zones where U.S.-registered cars can skip the temporary import permit (Baja California, Baja California Sur and part of Sonora) |
|---|---|
| Mexican auto insurance | Required for all vehicles: buy a Mexican policy before you drive |
Sources: U.S. State Department, Mexico travel information (updated August 11, 2026); permits are issued by Banjercito.
What the drive from Guadalupe, Zacatecas to Apizaco is like
MEX-45D (163 mi) and MEX-M40D (87 mi) carry about 58% of the 432 miles. MEX-45D, MEX-47D, MEX-57D, MEX-M40D are toll highways (cuota); MEX-45, MEX-136 are free federal roads (libre). It runs through 8 states: Zacatecas, Aguascalientes, Jalisco, Guanajuato, Querétaro, State of Mexico, Hidalgo, Tlaxcala. Of the 8 stops listed below, 2 are within a mile of the road.
The route from Guadalupe, Zacatecas to Apizaco, road by road
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–4 | 4 | Zacatecas |
| MEX-45D | 4–25 | 21 | Zacatecas |
| MEX-45 | 25–53 | 28 | Zacatecas, Aguascalientes |
| local roads | 53–57 | 4 | Aguascalientes |
| MEX-45 | 57–87 | 30 | Aguascalientes, Jalisco |
| MEX-45D | 87–229 | 142 | Jalisco, Guanajuato |
| MEX-47D | 229–281 | 52 | Guanajuato, Querétaro |
| MEX-57D | 281–316 | 35 | Querétaro, State of Mexico |
| connecting roads | 316–318 | 2 | Hidalgo |
| MEX-M40D | 318–405 | 87 | Hidalgo, State of Mexico, Tlaxcala |
| MEX-136 | 405–432 | 27 | Tlaxcala |
- Mile 30 of this route: Zacatecas → Aguascalientes (state line)
- Mile 83 of this route: Aguascalientes → Jalisco (state line)
- Mile 132 of this route: Jalisco → Guanajuato (state line)
- Mile 242 of this route: Guanajuato → Querétaro (state line)
- Mile 283 of this route: Querétaro → State of Mexico (state line)
- Mile 316 of this route: State of Mexico → Hidalgo (state line)
- Mile 345 of this route: Hidalgo → State of Mexico (state line)
- Mile 360 of this route: State of Mexico → Hidalgo (state line)
- Mile 377 of this route: Hidalgo → State of Mexico (state line)
- Mile 389 of this route: State of Mexico → Hidalgo (state line)
- Mile 396 of this route: Hidalgo → Tlaxcala (state line)
Stops between Guadalupe, Zacatecas and Apizaco
- Right off the route (under 1 mile): Aguascalientes Museum (mile 68), Tula National Park (mile 329)
- Nature and outdoors: El Cimatario National Park (mile 246), Tula National Park (mile 329)
- Museums and history: Museo de la Insurgencia (mile 48), Aguascalientes Museum (mile 68), Celaya Cathedral (mile 217), Teotihuacan (mile 377)
Museo de la Insurgencia
Set in a 17th-century estate, the Museo de la Insurgencia opened in 1964 to tell the story of Mexico's independence movement. One hall shows farm, mining and textile tools from hacienda work; another displays everyday objects from past eras.
Aguascalientes Museum
Located in the state capital, the Aguascalientes Museum is the city's art museum, set in the city of Aguascalientes, Mexico.
Celaya Cathedral
Celaya's main Catholic church, the Immaculate Conception Cathedral, occupies the space of a former chapel that was annexed to the neighboring Temple of St. Francis.
El Cimatario National Park
El Cimatario National Park protects about 24 square kilometers of land just south of the city of Santiago de Querétaro.
Tula National Park
This park protects the ruins of Tula, ancient capital of the Toltecs. Walk up to the main pyramid to stand beside the Atlantes, basalt warrior figures more than four meters tall, and look for the Coatepantli wall's reliefs of snakes devouring skeletons.
Church and former convent of Todos los Santos
Franciscan friars built this fortress-style convent in Zempoala, and the complex still keeps the classic layout of atrium, church, open chapel and cloister. It pairs well with a drive through the area's old pulque haciendas.
Teotihuacan
Built between the 1st and 7th centuries AD, this UNESCO-listed ancient city lines the Avenue of the Dead, where you can walk between the Pyramid of the Sun, the Pyramid of the Moon and the Temple of the Feathered Serpent.
Aqueduct of Padre Tembleque
Built by Franciscan friar Francisco de Tembleque between 1554 and 1572, this 16th-century water system runs more than 48 km between Zempoala and Otumba. Its tallest arcade at Tepeyahualco reaches almost 40 meters, and UNESCO listed it in 2015.
When you get to Apizaco
Basílica de Nuestra Señora de las Misericordias, Apizaco
In the city of Apizaco, this Catholic basilica (Basílica de Nuestra Señora de la Misericordia) was begun in the third decade of the 20th century and completed in 1961.
Museo Casa de Piedra
Apizaco's old railroad station, dating from 1916, now houses the Museo Casa de Piedra. Inside, photographs and documents trace the town's history, especially its long ties to the railroads.
Ex Convento de Santa María de la Concepción Atlihuetzia
The ruined walls of this 16th-century Franciscan convent in Atlihuetzia rise as high as 21 meters beside the 17th-century Purísima Concepción church. The site also holds a sanctuary to Cristóbal, honored as the first Catholic child martyr in the Americas.
More drives to Apizaco
- Mexico City to Apizaco
- Tepotzotlán to Apizaco
- Cuautla to Apizaco
- Toluca to Apizaco
- Cuernavaca to Apizaco
- Taxco to Apizaco
From Guadalupe, Zacatecas to other places in Mexico
- Guadalupe, Zacatecas to San Juan de los Lagos
- Guadalupe, Zacatecas to Temacapulín
- Guadalupe, Zacatecas to Tepatitlán
- Guadalupe, Zacatecas to Amatitán
- Guadalupe, Zacatecas to Ajijic
- Guadalupe, Zacatecas to Tequila
Continue Your Adventure
Frequently asked questions
How long is the drive from Guadalupe, Zacatecas to Apizaco?
About 7 h 17 min of driving without stops, over 432 miles.
How far is Apizaco from Guadalupe, Zacatecas by car?
About 432 miles (696 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Do I need a permit to drive my U.S. car from Guadalupe, Zacatecas to Apizaco?
Yes. A temporary vehicle import permit (TIP) is required for a U.S.-registered car on this route, which is outside the zones where it can be skipped. Mexican auto insurance is required for every vehicle.
Is it safe to drive from Guadalupe, Zacatecas to Apizaco?
The U.S. State Department rates Zacatecas Level 4: Do Not Travel; Aguascalientes Level 2: Exercise Increased Caution; Jalisco Level 3: Reconsider Travel; Guanajuato Level 3: Reconsider Travel; Querétaro Level 2: Exercise Increased Caution; State of Mexico Level 2: Exercise Increased Caution; Hidalgo Level 2: Exercise Increased Caution; Tlaxcala Level 2: Exercise Increased Caution (advisory issued May 29, 2026). Read the full advisory before you go.
What roads does the drive from Guadalupe, Zacatecas to Apizaco use?
In order: MEX-45D, MEX-45, MEX-47D, MEX-57D, MEX-M40D and MEX-136. The road-by-road table above shows the route miles and states for each one.
What are good stops between Guadalupe, Zacatecas and Apizaco?
Closest to the road: Aguascalientes Museum (art museum, mile 68, 0.4 mi from the route); Tula National Park (National Park of Mexico, mile 329, 1 mi from the route); Aqueduct of Padre Tembleque (aqueduct, mile 379, 2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway mile markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route (roughly 2 to 7 miles depending on the type, farther for World Heritage sites): at least one strong stop for each stretch of the drive, then the best-known places nearest the road, with no more than five of one type, up to nine in all. Places that are closed, private or not open to visitors are removed. Place and city descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on September 29, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.