The Wayro route from Colón, Argentina to Treinta y Tres, Uruguay is 398 miles (640 km), about 8 h 13 min of driving without stops. You cross from Argentina into Uruguay at about mile 6, at the Colón–Paysandú bridge.
Full advisory: Argentina, Uruguay. Advisory issued: Argentina July 10, 2026; Uruguay July 28, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Gas stations are often far apart and not always easily identified from the main roadway.”
- Uruguay: “Several of the main highways are particularly accident-ridden.”
| Distance | 398 mi (640 km) |
|---|---|
| Drive time without stops | 8 h 13 min |
| Border crossing | about mile 6, Argentina → Uruguay (the Colón–Paysandú bridge) |
| Regions on the route | Entre Ríos, Paysandú, Río Negro, Flores, San José, Canelones, Lavalleja, Treinta y Tres |
| Fuel estimate (car at 25 mpg) | about 15.9 gal; actual use varies by vehicle and traffic |
| Stops listed below | 8 |
Crossing from Argentina into Uruguay
The route crosses at about mile 6, at the Colón–Paysandú bridge, from Entre Ríos into Paysandú. Plan on two checks on each side: immigration for your passport and customs for the car.
| Entering Uruguay (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. |
|---|---|
| Driving in Uruguay | You can drive on your U.S. license. |
| Entering Argentina (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid when you enter; leave a blank page for the entry and exit stamps. |
| Driving in Argentina | A valid U.S. license usually works; an International Driving Permit is recommended. |
| Rental car | Cross only if the rental company authorizes it in writing and gives you the papers for the border; ask before you book. |
Sources: U.S. State Department, Uruguay (updated August 13, 2026); U.S. State Department, Argentina (updated July 16, 2026). Checked October 10, 2026; rules change, so confirm before you go.
The Colón–Treinta y Tres drive in a few lines
The first 6 miles are in Argentina; the last 392 are in Uruguay. It runs through 8 regions: Entre Ríos, Paysandú, Río Negro, Flores, San José, Canelones, Lavalleja, Treinta y Tres. Of the 8 stops listed below, 3 are within a mile of the road.
Roads you'll take from Colón to Treinta y Tres
| Road | Route miles (from–to) | Length, mi | Region |
|---|---|---|---|
| local roads | 0–398 | 398 | Entre Ríos, Paysandú, Río Negro, Flores, San José, Canelones, Lavalleja, Treinta y Tres |
- Mile 6 of this route: Entre Ríos → Paysandú (international border)
- Mile 39 of this route: Paysandú → Río Negro (region line)
- Mile 94 of this route: Río Negro → Flores (region line)
- Mile 155 of this route: Flores → San José (region line)
- Mile 204 of this route: San José → Canelones (region line)
- Mile 270 of this route: Canelones → Lavalleja (region line)
- Mile 381 of this route: Lavalleja → Treinta y Tres (region line)
Breaking up the drive: stops between Colón and Treinta y Tres
- Right off the route (under 1 mile): Reserva de Flora y fauna Dr. Rodolfo Tálice (mile 122), Cathedral of Our Lady of Guadalupe (mile 215), Cathedral of Minas (mile 295)
- Nature and outdoors: Reserva de Flora y fauna Dr. Rodolfo Tálice (mile 122), Laguna del Cisne (mile 250), Parque nacional Arequita (mile 296), Salto del Penitente (mile 305)
- Museums and history: Nuestra Señora del Rosario y San Benito de Palermo, Paysandú (mile 13), Cathedral of Our Lady of Guadalupe (mile 215), Iglesia de Cristo Obrero y Nuestra Señora de Lourdes (mile 251), Cathedral of Minas (mile 295)
Nuestra Señora del Rosario y San Benito de Palermo, Paysandú
Paysandú's Catholic parish church of Our Lady of the Rosary and St. Benedict of Palermo was named a minor basilica in 1949 and remains an active parish of the city.
Reserva de Flora y fauna Dr. Rodolfo Tálice
Off Route 3 near Trinidad, the Dr. Rodolfo Tálice Ecopark (Reserva de Flora y Fauna Dr. Rodolfo Talice) is a fenced wildlife reserve where axis deer, greater rheas and pampas deer roam free alongside other species.
Cathedral of Our Lady of Guadalupe
Construction of Canelones' Cathedral of Our Lady of Guadalupe began in 1816; the church became a cathedral in 1961 and Uruguay's national shrine of Our Lady of Guadalupe in 2020.
Laguna del Cisne
Near Salinas in Canelones, Laguna del Cisne is a subtropical lagoon of about 1.8 km², fed by a watershed of some 50 km², that has supplied drinking water to the Costa de Oro area since 1970.
Iglesia de Cristo Obrero y Nuestra Señora de Lourdes
Wavy brick walls and a rippling brick roof define this church in Estación Atlántida, along with an openwork brick bell tower and a baptistery set underground. Engineer Eladio Dieste designed it, and it opened in 1960.
Cathedral of Minas
Minas's main Catholic church, the Cathedral of the Immaculate Conception served as the seat of the Diocese of Minas from 1960 to 2020.
Parque nacional Arequita
Arequita National Park is a protected natural area in Lavalleja department, southeastern Uruguay, known for Cerro Arequita, its related rock formations and its biodiversity.
Salto del Penitente
Arriving in Treinta y Tres
Museo Agustín Araújo
Treinta y Tres's departmental fine arts museum, the Museo Agustín Araújo is a public museum in the city of Treinta y Tres, Uruguay.
More drives to Treinta y Tres
- Montevideo to Treinta y Tres
- Rivera to Treinta y Tres
- Colonia del Sacramento to Treinta y Tres
- Salto to Treinta y Tres
- Fray Bentos to Treinta y Tres
- Buenos Aires to Treinta y Tres, Uruguay
More drives from Colón
- Colón, Argentina to Adrogué
- Colón, Argentina to Magdalena
- Colón, Argentina to Chascomús
- Colón, Argentina to Cariló
- Colón, Argentina to Villa Gesell
- Colón, Argentina to Capilla del Monte
Continue Your Adventure
Frequently asked questions
How long does it take to drive from Colón, Argentina to Treinta y Tres, Uruguay?
About 8 h 13 min of driving without stops, over 398 miles.
How far is Treinta y Tres, Uruguay from Colón, Argentina by car?
About 398 miles (640 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Where does the Colón to Treinta y Tres drive cross the border?
At about mile 6, from Argentina into Uruguay, at the Colón–Paysandú bridge.
What do U.S. citizens need to drive from Colón into Uruguay?
No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. You can drive on your U.S. license. (U.S. State Department, updated August 13, 2026.)
Is it safe to drive from Colón, Argentina to Treinta y Tres, Uruguay?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions; Uruguay Level 2: Exercise Increased Caution. Read the full advisory before you go.
What are good stops between Colón and Treinta y Tres?
Closest to the road: Reserva de Flora y fauna Dr. Rodolfo Tálice (botanical garden, mile 122, 0.1 mi from the route); Cathedral of Our Lady of Guadalupe (cathedral, mile 215, 0.2 mi from the route); Cathedral of Minas (cathedral, mile 295, 0.6 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.