The Wayro route from Calama to Humahuaca, Argentina is 359 miles (578 km), about 7 h 39 min of driving without stops. You cross from Chile into Argentina at about mile 158, at Paso de Jama.
Full advisory: Chile, Argentina. Advisory issued: Chile August 19, 2026; Argentina July 10, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Chile: “Secondary and mountain roads may be poorly maintained, poorly lit, and may lack guardrails.”
- Argentina: “Gas stations are often far apart and not always easily identified from the main roadway.”
| Distance | 359 mi (578 km) |
|---|---|
| Time at the wheel, no stops | 7 h 39 min |
| Main roads, in order | RN52 → RN9 |
| Border crossing | about mile 158, Chile → Argentina (Paso de Jama) |
| Regions on the route | Antofagasta, Jujuy, Salta |
| Fuel estimate (car at 25 mpg) | about 14.4 gal; actual use varies by vehicle and traffic |
| Stops listed below | 9 |
Border crossing: what to bring for Argentina
The route crosses at about mile 158, at Paso de Jama, from Antofagasta into Jujuy. Plan on two checks on each side: immigration for your passport and customs for the car.
| Entering Argentina (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid when you enter; leave a blank page for the entry and exit stamps. |
|---|---|
| Driving in Argentina | A valid U.S. license usually works; an International Driving Permit is recommended. |
| Entering Chile (U.S. citizens) | No visa needed for 90 days or less on a tourist passport; you get a Tourist Card valid for up to 90 days. Passport: must be valid for your whole stay. |
| Driving in Chile | A valid U.S. license works for the length of your tourist permit, usually 90 days. |
| The car, entering Argentina | Argentine customs (ARCA) registers the car's temporary entry. Bring the title or registration, liability insurance valid in Argentina and, if you don't own the car, a power of attorney signed before a notary. A rental car needs the rental company's MERCOSUR circulation authorization (ACM), and the company must be registered with Argentine customs. |
| Rental car | Cross only if the rental company authorizes it in writing and gives you the papers for the border; ask before you book. |
Sources: U.S. State Department, Argentina (updated July 16, 2026); U.S. State Department, Chile (updated July 02, 2026); ARCA (Argentine customs). Checked October 10, 2026; rules change, so confirm before you go.
The Calama–Humahuaca drive in a few lines
RN52 (160 mi) and RN9 (40 mi) carry about 56% of the 359 miles. The first 158 miles are in Chile; the last 201 are in Argentina. It runs through 3 regions: Antofagasta, Jujuy, Salta. Of the 9 stops listed below, 6 are within a mile of the road.
Roads you'll take from Calama to Humahuaca
| Road | Route miles (from–to) | Length, mi | Region |
|---|---|---|---|
| local roads | 0–61 | 61 | Antofagasta |
| connecting roads | 61–62 | 1 | Antofagasta |
| local roads | 62–159 | 97 | Antofagasta, Jujuy |
| RN52 | 159–319 | 160 | Jujuy, Salta |
| RN9 | 319–359 | 40 | Jujuy |
- Mile 158 of this route: Antofagasta → Jujuy (international border)
- Mile 232 of this route: Jujuy → Salta (region line)
- Mile 266 of this route: Salta → Jujuy (region line)
Breaking up the drive: stops between Calama and Humahuaca
- Right off the route (under 1 mile): Pukará de Quitor (mile 60), Museo del Meteorito (mile 62), Los Flamencos National Reserve (mile 131), Salar Aguas Calientes I (mile 132), Pucará de Tilcara (mile 331), José Antonio Terry Regional Museum of Painting (mile 332)
- Nature and outdoors: Museo del Meteorito (mile 62), Los Flamencos National Reserve (mile 131)
- Museums and history: Pukará de Quitor (mile 60), Museo del Meteorito (mile 62), Pucará de Tilcara (mile 331), José Antonio Terry Regional Museum of Painting (mile 332)
Pukará de Quitor
About 3 km northwest of San Pedro de Atacama, Pukará de Quitor is a pre-Columbian stone fortress overlooking the valley of the San Pedro River.
Museo del Meteorito
San Pedro de Atacama's Museo del Meteorito keeps a permanent exhibit of meteorites found in the Atacama Desert of northern Chile.
Los Flamencos National Reserve
Covering 740 square kilometres of dry puna in the San Pedro de Atacama commune, Los Flamencos National Reserve is made up of seven separate sections in the Antofagasta Region.
Salar Aguas Calientes I
High in the Puna de Atacama of the Antofagasta Region, Salar Aguas Calientes I borders the Tara salt flat to the north and east, Quisquiro to the south and Pujsa to the west.
Salar de Quisquiro
Also called Salar de Loyoques, Salar de Quisquiro is a salt pan of about 80 km² in northern Chile, in a basin averaging 4,430 m and topped by 5,285 m Cerro Purifican.
Salar de Olaroz
In the Susques department of Jujuy province, about 270 km from San Salvador de Jujuy, Salar de Olaroz lies on a high plateau at around 3,900 m.
Salinas Grandes
Spread across Jujuy and Salta provinces at about 3,450 meters, the Salinas Grandes salt flat covers 212 square kilometers of white desert.
Pucará de Tilcara
On a hill just outside Tilcara in Jujuy, the Pucará de Tilcara is a pre-Inca fortification placed for easy defense and good views over a long stretch of the Quebrada de Humahuaca.
José Antonio Terry Regional Museum of Painting
On Rivadavia street in Tilcara, Jujuy, the Museo Nacional Terry occupies the colonial-style house where painter José Antonio Terry lived and focuses on his paintings.
More drives to Humahuaca
- Cafayate to Humahuaca
- Santa María, Argentina to Humahuaca
- Catamarca to Humahuaca
- La Rioja to Humahuaca
- Llallagua to Humahuaca, Argentina
More drives from Calama
- Calama to Putre
- Calama to Copiapó
- Calama to Tarabuco, Bolivia
- Calama to San Pedro de Quemes Canton, Bolivia
- Calama to La Quiaca, Argentina
Frequently asked questions
How long is the drive from Calama to Humahuaca, Argentina?
About 7 h 39 min of driving without stops, over 359 miles.
What is the driving distance from Calama to Humahuaca, Argentina?
About 359 miles (578 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Where does the Calama to Humahuaca drive cross the border?
At about mile 158, from Chile into Argentina, at Paso de Jama.
What do U.S. citizens need to drive from Calama into Argentina?
No visa needed for visits of 90 days or less. Passport: must be valid when you enter; leave a blank page for the entry and exit stamps. A valid U.S. license usually works; an International Driving Permit is recommended. (U.S. State Department, updated July 16, 2026.)
Is it safe to drive from Calama to Humahuaca, Argentina?
The U.S. State Department rates Chile Level 2: Exercise Increased Caution; Argentina Level 1: Exercise Normal Precautions. Read the full advisory before you go.
Which highways go from Calama to Humahuaca?
In order: RN52 and RN9. The road-by-road table above shows the route miles for each one.
What are good stops between Calama and Humahuaca?
Closest to the road: Museo del Meteorito (natural history museum, mile 62, 0.1 mi from the route); Los Flamencos National Reserve (national reserve, mile 131, 0.1 mi from the route); Pucará de Tilcara (fortress, mile 331, 0.3 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.