The Wayro route from Cafayate to Humahuaca is 269 miles (433 km), about 6 h 21 min of driving without stops.
Full advisory: Argentina. Advisory issued: Argentina July 10, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Gas stations are often far apart and not always easily identified from the main roadway.”
| Distance by road | 269 mi (433 km) |
|---|---|
| Drive time without stops | 6 h 21 min |
| Main roads, in order | RN68 → RP59 → RN9 → RN34 → RN1V66 |
| Provinces on the route | Salta, Jujuy |
| Fuel estimate (car at 25 mpg) | about 10.8 gal; actual use varies by vehicle and traffic |
| Stops listed below | 6 |
On the road from Cafayate to Humahuaca
RN68 (107 mi) and RN9 (104 mi) carry about 78% of the 269 miles. It runs through 2 provinces: Salta, Jujuy. Of the 6 stops listed below, 3 are within a mile of the road.
Which roads connect Cafayate and Humahuaca
| Road | Route miles (from–to) | Length, mi | Province |
|---|---|---|---|
| local roads | 0–2 | 2 | Salta |
| RN68 | 2–109 | 107 | Salta |
| connecting roads | 109–116 | 7 | Salta |
| RP59 | 116–120 | 4 | Salta |
| connecting roads | 120–121 | 1 | Salta |
| RN9 | 121–145 | 24 | Salta |
| RN34 | 145–165 | 20 | Salta, Jujuy |
| RN1V66 | 165–189 | 24 | Jujuy |
| RN9 | 189–269 | 80 | Jujuy |
- Mile 160 of this route: Salta → Jujuy (province line)
Breaking up the drive: stops between Cafayate and Humahuaca
- Right off the route (under 1 mile): Posta de Hornillos (mile 235), Pucará de Tilcara (mile 241), José Antonio Terry Regional Museum of Painting (mile 242)
- Museums and history: Salta Cathedral (mile 121), Cathedral Basilica of the Holy Saviour, San Salvador de Jujuy (mile 191), Museo Juan Galo Lavalle (mile 192), Posta de Hornillos (mile 235), Pucará de Tilcara (mile 241), José Antonio Terry Regional Museum of Painting (mile 242)
Salta Cathedral
Salta Cathedral is a Roman Catholic cathedral in Salta and serves as the seat and metropolitan cathedral of the Archbishop of Salta.
Cathedral Basilica of the Holy Saviour, San Salvador de Jujuy
The Cathedral Basilica of the Holy Saviour is the seat of the Catholic bishopric of San Salvador de Jujuy and is counted among Argentina's historic buildings.
Museo Juan Galo Lavalle
Inside a mid-18th-century house declared a National Historic Monument, this provincial history museum marks the place where independence-era leader Juan Galo Lavalle was killed.
Posta de Hornillos
Dating from the colonial era, the Posta de Hornillos is a former relay post in the Quebrada de Humahuaca, Tilcara department, that has worked as a history museum since 1979.
Pucará de Tilcara
On a hill just outside Tilcara in Jujuy, the Pucará de Tilcara is a pre-Inca fortification placed for easy defense and good views over a long stretch of the Quebrada de Humahuaca.
José Antonio Terry Regional Museum of Painting
On Rivadavia street in Tilcara, Jujuy, the Museo Nacional Terry occupies the colonial-style house where painter José Antonio Terry lived and focuses on his paintings.
More drives to Humahuaca
- Santa María, Argentina to Humahuaca
- Catamarca to Humahuaca
- La Rioja to Humahuaca
- Llallagua to Humahuaca, Argentina
- Calama to Humahuaca, Argentina
From Cafayate to other places in Argentina
- Cafayate to Villa Unión
- Cafayate to San Agustín de Valle Fértil
- Cafayate to San José de Jáchal
- Cafayate to Purmamarca
- Cafayate to Uquía
- Cafayate to Atocha, Bolivia
Frequently asked questions
How long is the drive from Cafayate to Humahuaca?
About 6 h 21 min of driving without stops, over 269 miles.
How far is Humahuaca from Cafayate by car?
About 269 miles (433 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the Cafayate to Humahuaca drive?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions. Read the full advisory before you go.
What roads does the drive from Cafayate to Humahuaca use?
In order: RN68, RP59, RN9, RN34 and RN1V66. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from Cafayate to Humahuaca?
Closest to the road: Posta de Hornillos (museum, mile 235, 0.1 mi from the route); Pucará de Tilcara (fortress, mile 241, 0.4 mi from the route); José Antonio Terry Regional Museum of Painting (historic house museum, mile 242, 0.6 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.